Chemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients

Abstract Many motile cells exhibit migratory behaviors, such as chemotaxis (motion up or down a chemical gradient) or chemokinesis (dependence of speed on chemical concentration), which enable them to carry out vital functions including immune response, egg fertilization, and predator evasion. These...

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Autores principales:	Jeffrey L. Moran, Philip M. Wheat, Nathan A. Marine, Jonathan D. Posner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f99b180729d44a04a486aca9b1fe3374
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spelling	oai:doaj.org-article:f99b180729d44a04a486aca9b1fe33742021-12-02T11:35:41ZChemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients10.1038/s41598-021-83963-x2045-2322https://doaj.org/article/f99b180729d44a04a486aca9b1fe33742021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83963-xhttps://doaj.org/toc/2045-2322Abstract Many motile cells exhibit migratory behaviors, such as chemotaxis (motion up or down a chemical gradient) or chemokinesis (dependence of speed on chemical concentration), which enable them to carry out vital functions including immune response, egg fertilization, and predator evasion. These have inspired researchers to develop self-propelled colloidal analogues to biological microswimmers, known as active colloids, that perform similar feats. Here, we study the behavior of half-platinum half-gold (Pt/Au) self-propelled rods in antiparallel gradients of hydrogen peroxide fuel and salt, which tend to increase and decrease the rods’ speed, respectively. Brownian Dynamics simulations, a Fokker–Planck theoretical model, and experiments demonstrate that, at steady state, the rods accumulate in low-speed (salt-rich, peroxide-poor) regions not because of chemotaxis, but because of chemokinesis. Chemokinesis is distinct from chemotaxis in that no directional sensing or reorientation capabilities are required. The agreement between simulations, model, and experiments bolsters the role of chemokinesis in this system. This work suggests a novel strategy of exploiting chemokinesis to effect accumulation of motile colloids in desired areas.Jeffrey L. MoranPhilip M. WheatNathan A. MarineJonathan D. PosnerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeffrey L. Moran Philip M. Wheat Nathan A. Marine Jonathan D. Posner Chemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients
description	Abstract Many motile cells exhibit migratory behaviors, such as chemotaxis (motion up or down a chemical gradient) or chemokinesis (dependence of speed on chemical concentration), which enable them to carry out vital functions including immune response, egg fertilization, and predator evasion. These have inspired researchers to develop self-propelled colloidal analogues to biological microswimmers, known as active colloids, that perform similar feats. Here, we study the behavior of half-platinum half-gold (Pt/Au) self-propelled rods in antiparallel gradients of hydrogen peroxide fuel and salt, which tend to increase and decrease the rods’ speed, respectively. Brownian Dynamics simulations, a Fokker–Planck theoretical model, and experiments demonstrate that, at steady state, the rods accumulate in low-speed (salt-rich, peroxide-poor) regions not because of chemotaxis, but because of chemokinesis. Chemokinesis is distinct from chemotaxis in that no directional sensing or reorientation capabilities are required. The agreement between simulations, model, and experiments bolsters the role of chemokinesis in this system. This work suggests a novel strategy of exploiting chemokinesis to effect accumulation of motile colloids in desired areas.
format	article
author	Jeffrey L. Moran Philip M. Wheat Nathan A. Marine Jonathan D. Posner
author_facet	Jeffrey L. Moran Philip M. Wheat Nathan A. Marine Jonathan D. Posner
author_sort	Jeffrey L. Moran
title	Chemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients
title_short	Chemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients
title_full	Chemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients
title_fullStr	Chemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients
title_full_unstemmed	Chemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients
title_sort	chemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f99b180729d44a04a486aca9b1fe3374
work_keys_str_mv	AT jeffreylmoran chemokinesisdrivenaccumulationofactivecolloidsinlowmobilityregionsoffuelgradients AT philipmwheat chemokinesisdrivenaccumulationofactivecolloidsinlowmobilityregionsoffuelgradients AT nathanamarine chemokinesisdrivenaccumulationofactivecolloidsinlowmobilityregionsoffuelgradients AT jonathandposner chemokinesisdrivenaccumulationofactivecolloidsinlowmobilityregionsoffuelgradients
_version_	1718395858019418112

Chemokinesis-driven accumulation of active colloids in low-mobility regions of fuel gradients

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