MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

In gastrointestinal stromal tumours early mutations in known genes are frequently followed by chromosome 14q deletion. Here the authors find mutations resulting in loss of MAX protein expression conserved between primary tumours and metastases in the same patients, suggesting thatMAXmutation is an e...

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Autores principales:	Inga-Marie Schaefer, Yuexiang Wang, Cher-wei Liang, Nacef Bahri, Anna Quattrone, Leona Doyle, Adrian Mariño-Enríquez, Alexandra Lauria, Meijun Zhu, Maria Debiec-Rychter, Susanne Grunewald, Jaclyn F. Hechtman, Armelle Dufresne, Cristina R. Antonescu, Carol Beadling, Ewa T. Sicinska, Matt van de Rijn, George D. Demetri, Marc Ladanyi, Christopher L. Corless, Michael C. Heinrich, Chandrajit P. Raut, Sebastian Bauer, Jonathan A. Fletcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f99b7b0f7dfb4944b7bbfdf9272bbf4d
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spelling	oai:doaj.org-article:f99b7b0f7dfb4944b7bbfdf9272bbf4d2021-12-02T17:06:09ZMAX inactivation is an early event in GIST development that regulates p16 and cell proliferation10.1038/ncomms146742041-1723https://doaj.org/article/f99b7b0f7dfb4944b7bbfdf9272bbf4d2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14674https://doaj.org/toc/2041-1723In gastrointestinal stromal tumours early mutations in known genes are frequently followed by chromosome 14q deletion. Here the authors find mutations resulting in loss of MAX protein expression conserved between primary tumours and metastases in the same patients, suggesting thatMAXmutation is an early event.Inga-Marie SchaeferYuexiang WangCher-wei LiangNacef BahriAnna QuattroneLeona DoyleAdrian Mariño-EnríquezAlexandra LauriaMeijun ZhuMaria Debiec-RychterSusanne GrunewaldJaclyn F. HechtmanArmelle DufresneCristina R. AntonescuCarol BeadlingEwa T. SicinskaMatt van de RijnGeorge D. DemetriMarc LadanyiChristopher L. CorlessMichael C. HeinrichChandrajit P. RautSebastian BauerJonathan A. FletcherNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Inga-Marie Schaefer Yuexiang Wang Cher-wei Liang Nacef Bahri Anna Quattrone Leona Doyle Adrian Mariño-Enríquez Alexandra Lauria Meijun Zhu Maria Debiec-Rychter Susanne Grunewald Jaclyn F. Hechtman Armelle Dufresne Cristina R. Antonescu Carol Beadling Ewa T. Sicinska Matt van de Rijn George D. Demetri Marc Ladanyi Christopher L. Corless Michael C. Heinrich Chandrajit P. Raut Sebastian Bauer Jonathan A. Fletcher MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
description	In gastrointestinal stromal tumours early mutations in known genes are frequently followed by chromosome 14q deletion. Here the authors find mutations resulting in loss of MAX protein expression conserved between primary tumours and metastases in the same patients, suggesting thatMAXmutation is an early event.
format	article
author	Inga-Marie Schaefer Yuexiang Wang Cher-wei Liang Nacef Bahri Anna Quattrone Leona Doyle Adrian Mariño-Enríquez Alexandra Lauria Meijun Zhu Maria Debiec-Rychter Susanne Grunewald Jaclyn F. Hechtman Armelle Dufresne Cristina R. Antonescu Carol Beadling Ewa T. Sicinska Matt van de Rijn George D. Demetri Marc Ladanyi Christopher L. Corless Michael C. Heinrich Chandrajit P. Raut Sebastian Bauer Jonathan A. Fletcher
author_facet	Inga-Marie Schaefer Yuexiang Wang Cher-wei Liang Nacef Bahri Anna Quattrone Leona Doyle Adrian Mariño-Enríquez Alexandra Lauria Meijun Zhu Maria Debiec-Rychter Susanne Grunewald Jaclyn F. Hechtman Armelle Dufresne Cristina R. Antonescu Carol Beadling Ewa T. Sicinska Matt van de Rijn George D. Demetri Marc Ladanyi Christopher L. Corless Michael C. Heinrich Chandrajit P. Raut Sebastian Bauer Jonathan A. Fletcher
author_sort	Inga-Marie Schaefer
title	MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
title_short	MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
title_full	MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
title_fullStr	MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
title_full_unstemmed	MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
title_sort	max inactivation is an early event in gist development that regulates p16 and cell proliferation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f99b7b0f7dfb4944b7bbfdf9272bbf4d
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MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

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