Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties.

Recent advances in microalgae biotechnology have proven that these microorganisms contain a number of bioactive molecules, that can be used as food additives that help prevent disease. The green microalga Chlorella vulgaris presents several biomolecules, such as lutein and astaxanthin, with antioxid...

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Autores principales:	Danielli M M Dantas, Thiago B Cahú, Carlos Yure B Oliveira, Ricardo Abadie-Guedes, Nathalia A Roberto, Werlayne M Santana, Alfredo O Gálvez, Rubem C A Guedes, Ranilson S Bezerra
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f99c2dbabe9e4e82b8d6f21600f558a6
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spelling	oai:doaj.org-article:f99c2dbabe9e4e82b8d6f21600f558a62021-12-02T20:18:29ZChlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties.1932-620310.1371/journal.pone.0255996https://doaj.org/article/f99c2dbabe9e4e82b8d6f21600f558a62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255996https://doaj.org/toc/1932-6203Recent advances in microalgae biotechnology have proven that these microorganisms contain a number of bioactive molecules, that can be used as food additives that help prevent disease. The green microalga Chlorella vulgaris presents several biomolecules, such as lutein and astaxanthin, with antioxidant capacity, which can play a protective role in tissues. In this study, we produced and analyzed a C. vulgaris functional alcoholic beverage (produced using a traditional Brazilian alcoholic beverage, cachaça, and C. vulgaris biomass). Assays were conducted in vitro by radical scavenging tests, and in vivo, by modeling cortical spreading depression in rat brains. Scavenging radical assays showed that consumption of the C. vulgaris alcoholic beverage had a DPPH inhibition of 77.2%. This functional alcoholic beverage at a concentration of 12.5 g L-1 significantly improved cortical spreading depression velocity in the rat brains (2.89 mm min-1), when compared with cachaça alone (3.68 mm min-1) and control (distilled water; 3.25 mm min-1). Moreover, animals that consumed the functional beverage gained less weight than those that consumed just alcohol and the control groups. These findings suggest that the C. vulgaris functional alcoholic beverage plays a protective physiologic role in protecting brain cells from the effects of drinking ethanol.Danielli M M DantasThiago B CahúCarlos Yure B OliveiraRicardo Abadie-GuedesNathalia A RobertoWerlayne M SantanaAlfredo O GálvezRubem C A GuedesRanilson S BezerraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255996 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danielli M M Dantas Thiago B Cahú Carlos Yure B Oliveira Ricardo Abadie-Guedes Nathalia A Roberto Werlayne M Santana Alfredo O Gálvez Rubem C A Guedes Ranilson S Bezerra Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties.
description	Recent advances in microalgae biotechnology have proven that these microorganisms contain a number of bioactive molecules, that can be used as food additives that help prevent disease. The green microalga Chlorella vulgaris presents several biomolecules, such as lutein and astaxanthin, with antioxidant capacity, which can play a protective role in tissues. In this study, we produced and analyzed a C. vulgaris functional alcoholic beverage (produced using a traditional Brazilian alcoholic beverage, cachaça, and C. vulgaris biomass). Assays were conducted in vitro by radical scavenging tests, and in vivo, by modeling cortical spreading depression in rat brains. Scavenging radical assays showed that consumption of the C. vulgaris alcoholic beverage had a DPPH inhibition of 77.2%. This functional alcoholic beverage at a concentration of 12.5 g L-1 significantly improved cortical spreading depression velocity in the rat brains (2.89 mm min-1), when compared with cachaça alone (3.68 mm min-1) and control (distilled water; 3.25 mm min-1). Moreover, animals that consumed the functional beverage gained less weight than those that consumed just alcohol and the control groups. These findings suggest that the C. vulgaris functional alcoholic beverage plays a protective physiologic role in protecting brain cells from the effects of drinking ethanol.
format	article
author	Danielli M M Dantas Thiago B Cahú Carlos Yure B Oliveira Ricardo Abadie-Guedes Nathalia A Roberto Werlayne M Santana Alfredo O Gálvez Rubem C A Guedes Ranilson S Bezerra
author_facet	Danielli M M Dantas Thiago B Cahú Carlos Yure B Oliveira Ricardo Abadie-Guedes Nathalia A Roberto Werlayne M Santana Alfredo O Gálvez Rubem C A Guedes Ranilson S Bezerra
author_sort	Danielli M M Dantas
title	Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties.
title_short	Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties.
title_full	Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties.
title_fullStr	Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties.
title_full_unstemmed	Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties.
title_sort	chlorella vulgaris functional alcoholic beverage: effect on propagation of cortical spreading depression and functional properties.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f99c2dbabe9e4e82b8d6f21600f558a6
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Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties.

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