The efficacy of Li in bipolar disorder

R Lozano,1 R Marín,2 MJ Santacruz,2 I Freire,2 R Gomez21Department of Pharmacy, 2Department of Psychiatry, Hospital Real Nuestra Señora de Gracia, Zaragoza, SpainThe efficacy of lithium (Li) for acute mania and as prophylaxis against recurrent episodes of mania in bipolar disor...

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Autores principales:	Lozano R, Mar&iacute;n R, Santacruz MJ, Freire I, Gomez R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f99cc6e7bc1d410895a04f30dd57273e
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spelling	oai:doaj.org-article:f99cc6e7bc1d410895a04f30dd57273e2021-12-02T05:03:34ZThe efficacy of Li in bipolar disorder1176-63281178-2021https://doaj.org/article/f99cc6e7bc1d410895a04f30dd57273e2013-07-01T00:00:00Zhttp://www.dovepress.com/the-efficacy-of-li-in-bipolar-disorder-a13646https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021R Lozano,1 R Marín,2 MJ Santacruz,2 I Freire,2 R Gomez21Department of Pharmacy, 2Department of Psychiatry, Hospital Real Nuestra Señora de Gracia, Zaragoza, SpainThe efficacy of lithium (Li) for acute mania and as prophylaxis against recurrent episodes of mania in bipolar disorder has been well established, with the minimum effective Li serum concentration for acute mania in the range of 0.6–1.2 mEq/L, although lower maintenance concentrations can prove effective in some patients.1–5Thyroid disorders are also associated with alterations in mood, and patients with hypothyroidism may present with depression and cognitive dysfunction,6–8 while patients with hyperthyroidism may present with anxiety, depression, mood lability,7,9 and manic symptoms.10 However, considering that overt hyperthyroidism is uncommon in bipolar disorder, with a prevalence ≤2% across different studies,11,12 this has been largely attributed to lithium,13 with rates varying from 0 to 47% (average of about 10%) among patients on long-term treatment with lithium.13–16Lozano RMar&iacute;n RSantacruz MJFreire IGomez RDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 953-954 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lozano R Mar&iacute;n R Santacruz MJ Freire I Gomez R The efficacy of Li in bipolar disorder
description	R Lozano,1 R Marín,2 MJ Santacruz,2 I Freire,2 R Gomez21Department of Pharmacy, 2Department of Psychiatry, Hospital Real Nuestra Señora de Gracia, Zaragoza, SpainThe efficacy of lithium (Li) for acute mania and as prophylaxis against recurrent episodes of mania in bipolar disorder has been well established, with the minimum effective Li serum concentration for acute mania in the range of 0.6–1.2 mEq/L, although lower maintenance concentrations can prove effective in some patients.1–5Thyroid disorders are also associated with alterations in mood, and patients with hypothyroidism may present with depression and cognitive dysfunction,6–8 while patients with hyperthyroidism may present with anxiety, depression, mood lability,7,9 and manic symptoms.10 However, considering that overt hyperthyroidism is uncommon in bipolar disorder, with a prevalence ≤2% across different studies,11,12 this has been largely attributed to lithium,13 with rates varying from 0 to 47% (average of about 10%) among patients on long-term treatment with lithium.13–16
format	article
author	Lozano R Mar&iacute;n R Santacruz MJ Freire I Gomez R
author_facet	Lozano R Mar&iacute;n R Santacruz MJ Freire I Gomez R
author_sort	Lozano R
title	The efficacy of Li in bipolar disorder
title_short	The efficacy of Li in bipolar disorder
title_full	The efficacy of Li in bipolar disorder
title_fullStr	The efficacy of Li in bipolar disorder
title_full_unstemmed	The efficacy of Li in bipolar disorder
title_sort	efficacy of li in bipolar disorder
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f99cc6e7bc1d410895a04f30dd57273e
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The efficacy of Li in bipolar disorder

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