The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis

Background. Ischemic stroke combined with hypertension can increase risks of stroke recurrence and death. Aim. The aim of this study is to investigate the clinical efficacy of clopidogrel bisulfate tablets combined with olmesartan medoxomil in the treatment of ischemic stroke patients with hypertens...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jia Yu, Wei Fang, Xing Guo, Haiyang Jiang, Peng Sun, Yufeng Liu, Xin Jin
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Computer applications to medicine. Medical informatics R858-859.7
Acceso en línea:	https://doaj.org/article/f9a29926d4ce4a7aacdd9c1c3d8d232e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f9a29926d4ce4a7aacdd9c1c3d8d232e
record_format	dspace
spelling	oai:doaj.org-article:f9a29926d4ce4a7aacdd9c1c3d8d232e2021-11-08T02:37:21ZThe Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis1748-671810.1155/2021/4487393https://doaj.org/article/f9a29926d4ce4a7aacdd9c1c3d8d232e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4487393https://doaj.org/toc/1748-6718Background. Ischemic stroke combined with hypertension can increase risks of stroke recurrence and death. Aim. The aim of this study is to investigate the clinical efficacy of clopidogrel bisulfate tablets combined with olmesartan medoxomil in the treatment of ischemic stroke patients with hypertension and the effect of angiotensin II type 1 receptor (AT1R) level on prognosis. Methods. Ninety ischemic stroke patients with hypertension were chosen for continuous treatment with clopidogrel bisulfate tablets and olmesartan medoxomil for 12 months. The Modified Edinburgh Scandinavian Stroke Scale (MESSS) score, Brunnstrom score, Barthel score, death, recurrence, and progression of cerebrovascular residual lesions were observed and recorded during the treatment period. According to the plasma AT1R expression of the patients before treatment, the patients were divided into a high-AT1R group and low-AT1R group. Then, survival analysis was performed. Results. Compared with pretreatment, the MESSS scores of the patients at the first, second, third, sixth, ninth, and twelfth months after treatment were reduced (p<0.01) while the Brunnstrom score and Barthel score were prominently boosted (p<0.01). Compared with the low-AT1R group, patients in the high-AT1R group had higher rates of stroke recurrence and progression of residual cerebrovascular lesions (p<0.05). Conclusion. Clopidogrel bisulfate tablets combined with olmesartan medoxomil has prominent clinical effects in the treatment of ischemic stroke patients with hypertension, evidently improving the prognosis. In addition, the level of AT1R may be a vital factor affecting the prognosis.Jia YuWei FangXing GuoHaiyang JiangPeng SunYufeng LiuXin JinHindawi LimitedarticleComputer applications to medicine. Medical informaticsR858-859.7ENComputational and Mathematical Methods in Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computer applications to medicine. Medical informatics R858-859.7
spellingShingle	Computer applications to medicine. Medical informatics R858-859.7 Jia Yu Wei Fang Xing Guo Haiyang Jiang Peng Sun Yufeng Liu Xin Jin The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis
description	Background. Ischemic stroke combined with hypertension can increase risks of stroke recurrence and death. Aim. The aim of this study is to investigate the clinical efficacy of clopidogrel bisulfate tablets combined with olmesartan medoxomil in the treatment of ischemic stroke patients with hypertension and the effect of angiotensin II type 1 receptor (AT1R) level on prognosis. Methods. Ninety ischemic stroke patients with hypertension were chosen for continuous treatment with clopidogrel bisulfate tablets and olmesartan medoxomil for 12 months. The Modified Edinburgh Scandinavian Stroke Scale (MESSS) score, Brunnstrom score, Barthel score, death, recurrence, and progression of cerebrovascular residual lesions were observed and recorded during the treatment period. According to the plasma AT1R expression of the patients before treatment, the patients were divided into a high-AT1R group and low-AT1R group. Then, survival analysis was performed. Results. Compared with pretreatment, the MESSS scores of the patients at the first, second, third, sixth, ninth, and twelfth months after treatment were reduced (p<0.01) while the Brunnstrom score and Barthel score were prominently boosted (p<0.01). Compared with the low-AT1R group, patients in the high-AT1R group had higher rates of stroke recurrence and progression of residual cerebrovascular lesions (p<0.05). Conclusion. Clopidogrel bisulfate tablets combined with olmesartan medoxomil has prominent clinical effects in the treatment of ischemic stroke patients with hypertension, evidently improving the prognosis. In addition, the level of AT1R may be a vital factor affecting the prognosis.
format	article
author	Jia Yu Wei Fang Xing Guo Haiyang Jiang Peng Sun Yufeng Liu Xin Jin
author_facet	Jia Yu Wei Fang Xing Guo Haiyang Jiang Peng Sun Yufeng Liu Xin Jin
author_sort	Jia Yu
title	The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis
title_short	The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis
title_full	The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis
title_fullStr	The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis
title_full_unstemmed	The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis
title_sort	clinical efficacy of clopidogrel bisulfate tablets combined with olmesartan medoxomil for ischemic stroke with hypertension and the effect of angiotensin ii type 1 receptor level on prognosis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/f9a29926d4ce4a7aacdd9c1c3d8d232e
work_keys_str_mv	AT jiayu theclinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT weifang theclinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT xingguo theclinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT haiyangjiang theclinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT pengsun theclinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT yufengliu theclinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT xinjin theclinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT jiayu clinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT weifang clinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT xingguo clinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT haiyangjiang clinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT pengsun clinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT yufengliu clinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis AT xinjin clinicalefficacyofclopidogrelbisulfatetabletscombinedwitholmesartanmedoxomilforischemicstrokewithhypertensionandtheeffectofangiotensiniitype1receptorlevelonprognosis
_version_	1718443058799837184

The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis

Ejemplares similares