Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration

Tsutomu Sakai, Sachiyo Okude, Hiroshi Tsuneoka Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan Purpose: To determine whether baseline foveal threshold and photoreceptor integrity can predict best-corrected visual acuity (BCVA) at 12 months after intravitreal afliberc...

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Autores principales:	Sakai T, Okude S, Tsuneoka H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	aflibercept age-related macular degeneration foveal threshold foveal photoreceptor integrity Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f9a2fe298ba94156a4474679ae36f165
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spelling	oai:doaj.org-article:f9a2fe298ba94156a4474679ae36f1652021-12-02T06:44:43ZFoveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration1177-5483https://doaj.org/article/f9a2fe298ba94156a4474679ae36f1652018-04-01T00:00:00Zhttps://www.dovepress.com/foveal-threshold-and-photoreceptor-integrity-for-prediction-of-visual--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tsutomu Sakai, Sachiyo Okude, Hiroshi Tsuneoka Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan Purpose: To determine whether baseline foveal threshold and photoreceptor integrity can predict best-corrected visual acuity (BCVA) at 12 months after intravitreal aflibercept (IVA) therapy in eyes with neovascular age-related macular degeneration (AMD). Patients and methods: We evaluated 25 eyes of 25 patients with treatment-naïve neovascular AMD who received IVA once a month for 3 months, followed by once every 2 months for 8 months. BCVA, integrity of the external limiting membrane (ELM) or the ellipsoid zone (EZ) of the photoreceptors, and retinal sensitivity were determined before (baseline) and at 6 and 12 months after initial IVA. The average threshold foveal sensitivity and mean deviation within the central 10° were determined by Humphrey central 10-2 perimetry. Correlations between BCVA at 12 months and integrity of the ELM or EZ, foveal threshold, and mean deviation at each visit were determined. Results: At 12 months, BCVA improved significantly from 0.20±0.23 to 0.10±0.22 logMAR (logarithm of the minimum angle of resolution) units, and foveal threshold and mean deviation improved significantly from 29.0±5.1 and -3.38±3.10 dB to 32.6±3.2 and -1.64±2.10 dB, respectively (P=0.0009 and P=0.0021). At baseline, both foveal threshold and integrity of the ELM were significantly correlated with BCVA at 12 months (P=0.0428 and P=0.0275). Conclusion: These results indicate that both integrity of the ELM and foveal threshold at baseline can predict BCVA after treatment for neovascular AMD. There is a possibility that these parameters can predict the efficacy of IVA in each case. Keywords: aflibercept, age-related macular degeneration, foveal threshold, foveal photoreceptor integritySakai TOkude STsuneoka HDove Medical Pressarticleafliberceptage-related macular degenerationfoveal thresholdfoveal photoreceptor integrityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 719-725 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	aflibercept age-related macular degeneration foveal threshold foveal photoreceptor integrity Ophthalmology RE1-994
spellingShingle	aflibercept age-related macular degeneration foveal threshold foveal photoreceptor integrity Ophthalmology RE1-994 Sakai T Okude S Tsuneoka H Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration
description	Tsutomu Sakai, Sachiyo Okude, Hiroshi Tsuneoka Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan Purpose: To determine whether baseline foveal threshold and photoreceptor integrity can predict best-corrected visual acuity (BCVA) at 12 months after intravitreal aflibercept (IVA) therapy in eyes with neovascular age-related macular degeneration (AMD). Patients and methods: We evaluated 25 eyes of 25 patients with treatment-naïve neovascular AMD who received IVA once a month for 3 months, followed by once every 2 months for 8 months. BCVA, integrity of the external limiting membrane (ELM) or the ellipsoid zone (EZ) of the photoreceptors, and retinal sensitivity were determined before (baseline) and at 6 and 12 months after initial IVA. The average threshold foveal sensitivity and mean deviation within the central 10° were determined by Humphrey central 10-2 perimetry. Correlations between BCVA at 12 months and integrity of the ELM or EZ, foveal threshold, and mean deviation at each visit were determined. Results: At 12 months, BCVA improved significantly from 0.20±0.23 to 0.10±0.22 logMAR (logarithm of the minimum angle of resolution) units, and foveal threshold and mean deviation improved significantly from 29.0±5.1 and -3.38±3.10 dB to 32.6±3.2 and -1.64±2.10 dB, respectively (P=0.0009 and P=0.0021). At baseline, both foveal threshold and integrity of the ELM were significantly correlated with BCVA at 12 months (P=0.0428 and P=0.0275). Conclusion: These results indicate that both integrity of the ELM and foveal threshold at baseline can predict BCVA after treatment for neovascular AMD. There is a possibility that these parameters can predict the efficacy of IVA in each case. Keywords: aflibercept, age-related macular degeneration, foveal threshold, foveal photoreceptor integrity
format	article
author	Sakai T Okude S Tsuneoka H
author_facet	Sakai T Okude S Tsuneoka H
author_sort	Sakai T
title	Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration
title_short	Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration
title_full	Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration
title_fullStr	Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration
title_full_unstemmed	Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration
title_sort	foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f9a2fe298ba94156a4474679ae36f165
work_keys_str_mv	AT sakait fovealthresholdandphotoreceptorintegrityforpredictionofvisualacuityafterintravitrealafliberceptonagerelatedmaculardegeneration AT okudes fovealthresholdandphotoreceptorintegrityforpredictionofvisualacuityafterintravitrealafliberceptonagerelatedmaculardegeneration AT tsuneokah fovealthresholdandphotoreceptorintegrityforpredictionofvisualacuityafterintravitrealafliberceptonagerelatedmaculardegeneration
_version_	1718399792353116160

Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration

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