Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes
Non-canonical HLA-bound peptides from presumed non-coding regions are potential targets for cancer immunotherapy, but their discovery remains challenging. Here, the authors integrate exome sequencing, transcriptomics, ribosome profiling, and immunopeptidomics to identify tumor-specific non-canonical...
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Nature Portfolio
2020
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oai:doaj.org-article:f9a358af84884389af3e4820907dade62021-12-02T17:31:55ZIntegrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes10.1038/s41467-020-14968-92041-1723https://doaj.org/article/f9a358af84884389af3e4820907dade62020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14968-9https://doaj.org/toc/2041-1723Non-canonical HLA-bound peptides from presumed non-coding regions are potential targets for cancer immunotherapy, but their discovery remains challenging. Here, the authors integrate exome sequencing, transcriptomics, ribosome profiling, and immunopeptidomics to identify tumor-specific non-canonical HLA-bound peptides.Chloe ChongMarkus MüllerHuiSong PakDermot HarnettFlorian HuberDelphine GrunMarion LeleuAymeric AugerMarion ArnaudBrian J. StevensonJustine MichauxIlija BilicAntje HirsekornLorenzo CalvielloLaia Simó-RiudalbasEvarist PlanetJan LubińskiMarta BryśkiewiczMaciej WiznerowiczIoannis XenariosLin ZhangDidier TronoAlexandre HarariUwe OhlerGeorge CoukosMichal Bassani-SternbergNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020) |
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Science Q Chloe Chong Markus Müller HuiSong Pak Dermot Harnett Florian Huber Delphine Grun Marion Leleu Aymeric Auger Marion Arnaud Brian J. Stevenson Justine Michaux Ilija Bilic Antje Hirsekorn Lorenzo Calviello Laia Simó-Riudalbas Evarist Planet Jan Lubiński Marta Bryśkiewicz Maciej Wiznerowicz Ioannis Xenarios Lin Zhang Didier Trono Alexandre Harari Uwe Ohler George Coukos Michal Bassani-Sternberg Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes |
| description |
Non-canonical HLA-bound peptides from presumed non-coding regions are potential targets for cancer immunotherapy, but their discovery remains challenging. Here, the authors integrate exome sequencing, transcriptomics, ribosome profiling, and immunopeptidomics to identify tumor-specific non-canonical HLA-bound peptides. |
| format |
article |
| author |
Chloe Chong Markus Müller HuiSong Pak Dermot Harnett Florian Huber Delphine Grun Marion Leleu Aymeric Auger Marion Arnaud Brian J. Stevenson Justine Michaux Ilija Bilic Antje Hirsekorn Lorenzo Calviello Laia Simó-Riudalbas Evarist Planet Jan Lubiński Marta Bryśkiewicz Maciej Wiznerowicz Ioannis Xenarios Lin Zhang Didier Trono Alexandre Harari Uwe Ohler George Coukos Michal Bassani-Sternberg |
| author_facet |
Chloe Chong Markus Müller HuiSong Pak Dermot Harnett Florian Huber Delphine Grun Marion Leleu Aymeric Auger Marion Arnaud Brian J. Stevenson Justine Michaux Ilija Bilic Antje Hirsekorn Lorenzo Calviello Laia Simó-Riudalbas Evarist Planet Jan Lubiński Marta Bryśkiewicz Maciej Wiznerowicz Ioannis Xenarios Lin Zhang Didier Trono Alexandre Harari Uwe Ohler George Coukos Michal Bassani-Sternberg |
| author_sort |
Chloe Chong |
| title |
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes |
| title_short |
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes |
| title_full |
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes |
| title_fullStr |
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes |
| title_full_unstemmed |
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes |
| title_sort |
integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/f9a358af84884389af3e4820907dade6 |
| work_keys_str_mv |
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1718380468677640192 |