Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery

Haolin Sun,1,2,* Lu Lv,3,* Yanjie Bai,4,* Huilin Yang,2,3 Huan Zhou,2,5 Chunde Li,1 Lei Yang2,3 1Department of Orthopaedics, Peking University First Hospital, Beijing 100034, China; 2International Research Center for Translational Orthopaedics (IRCTO), Soochow University, Suzhou 215006, China; 3Ort...

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Autores principales:	Sun H, Lv L, Bai Y, Yang H, Zhou H, Li C, Yang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Nanotechnology hemostatic antimicrobial orthopedic surgery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f9a61e294e3d412182b9c575e948c1b7
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spelling	oai:doaj.org-article:f9a61e294e3d412182b9c575e948c1b72021-12-02T05:22:46ZNanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery1178-2013https://doaj.org/article/f9a61e294e3d412182b9c575e948c1b72018-12-01T00:00:00Zhttps://www.dovepress.com/nanotechnology-enabled-materials-for-hemostatic-and-anti-infection-tre-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Haolin Sun,1,2,* Lu Lv,3,* Yanjie Bai,4,* Huilin Yang,2,3 Huan Zhou,2,5 Chunde Li,1 Lei Yang2,3 1Department of Orthopaedics, Peking University First Hospital, Beijing 100034, China; 2International Research Center for Translational Orthopaedics (IRCTO), Soochow University, Suzhou 215006, China; 3Orthopaedic Institute and Department of Orthopaedics, Soochow University, Suzhou 215006, China; 4School of Public Health, Medical College, Soochow University, Suzhou 215000, China; 5School of Mechanical Engineering, Jiangsu University of Technology, Changzhou 213001, China *These authors contributed equally to this work Abstract: The hemostatic and anti-infection treatments in the field of orthopedics are always the pivotal yet challenging topics. In the first part of this review, synthesized or naturally derived nanoscale agents and materials for hemostatic treatment in orthopedic surgery are introduced. The hemostatic mechanisms and the safety concerns of these nanotechnology-enabled materials are discussed. Beside the materials to meet hemostatic needs in orthopedic surgery, the need for antimicrobial or anti-infection strategy in orthopedic surgery also becomes urgent. Nanosilver and its derivatives have the most consistent anti-infective effect and thus high translational potential for clinical applications. In the second part, the factors affecting the antimicrobial effect of nanosilver and its application status are summarized. Finally, the status and translational potential of various nanotechnology-enabled materials and agents for hemostatic and anti-infective treatments in orthopedic surgery are discussed. Keywords: nanotechnology, hemostatic, antimicrobial, orthopedic surgerySun HLv LBai YYang HZhou HLi CYang LDove Medical PressarticleNanotechnologyhemostaticantimicrobialorthopedic surgeryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 8325-8338 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanotechnology hemostatic antimicrobial orthopedic surgery Medicine (General) R5-920
spellingShingle	Nanotechnology hemostatic antimicrobial orthopedic surgery Medicine (General) R5-920 Sun H Lv L Bai Y Yang H Zhou H Li C Yang L Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery
description	Haolin Sun,1,2,* Lu Lv,3,* Yanjie Bai,4,* Huilin Yang,2,3 Huan Zhou,2,5 Chunde Li,1 Lei Yang2,3 1Department of Orthopaedics, Peking University First Hospital, Beijing 100034, China; 2International Research Center for Translational Orthopaedics (IRCTO), Soochow University, Suzhou 215006, China; 3Orthopaedic Institute and Department of Orthopaedics, Soochow University, Suzhou 215006, China; 4School of Public Health, Medical College, Soochow University, Suzhou 215000, China; 5School of Mechanical Engineering, Jiangsu University of Technology, Changzhou 213001, China *These authors contributed equally to this work Abstract: The hemostatic and anti-infection treatments in the field of orthopedics are always the pivotal yet challenging topics. In the first part of this review, synthesized or naturally derived nanoscale agents and materials for hemostatic treatment in orthopedic surgery are introduced. The hemostatic mechanisms and the safety concerns of these nanotechnology-enabled materials are discussed. Beside the materials to meet hemostatic needs in orthopedic surgery, the need for antimicrobial or anti-infection strategy in orthopedic surgery also becomes urgent. Nanosilver and its derivatives have the most consistent anti-infective effect and thus high translational potential for clinical applications. In the second part, the factors affecting the antimicrobial effect of nanosilver and its application status are summarized. Finally, the status and translational potential of various nanotechnology-enabled materials and agents for hemostatic and anti-infective treatments in orthopedic surgery are discussed. Keywords: nanotechnology, hemostatic, antimicrobial, orthopedic surgery
format	article
author	Sun H Lv L Bai Y Yang H Zhou H Li C Yang L
author_facet	Sun H Lv L Bai Y Yang H Zhou H Li C Yang L
author_sort	Sun H
title	Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery
title_short	Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery
title_full	Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery
title_fullStr	Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery
title_full_unstemmed	Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery
title_sort	nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f9a61e294e3d412182b9c575e948c1b7
work_keys_str_mv	AT sunh nanotechnologyenabledmaterialsforhemostaticandantiinfectiontreatmentsinorthopedicsurgery AT lvl nanotechnologyenabledmaterialsforhemostaticandantiinfectiontreatmentsinorthopedicsurgery AT baiy nanotechnologyenabledmaterialsforhemostaticandantiinfectiontreatmentsinorthopedicsurgery AT yangh nanotechnologyenabledmaterialsforhemostaticandantiinfectiontreatmentsinorthopedicsurgery AT zhouh nanotechnologyenabledmaterialsforhemostaticandantiinfectiontreatmentsinorthopedicsurgery AT lic nanotechnologyenabledmaterialsforhemostaticandantiinfectiontreatmentsinorthopedicsurgery AT yangl nanotechnologyenabledmaterialsforhemostaticandantiinfectiontreatmentsinorthopedicsurgery
_version_	1718400450212921344

Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery

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