Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain

Abstract Clinical observations show that patients with anorexia nervosa (AN) are surprisingly free from infectious diseases. There is evidence from studies in Drosophila melanogaster that starvation leads to an increased expression of antimicrobial peptides (AMPs). AMPs are part of the innate immune...

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Autores principales:	Marie-Christin Bendix, Michael Stephan, Mariel Nöhre, Wally Wünsch-Leiteritz, Hagen Schmidt, Gisa Tiegs, Jürgen Harder, Martina de Zwaan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9a653f806b144c595cad39dd44b791d
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spelling	oai:doaj.org-article:f9a653f806b144c595cad39dd44b791d2021-12-02T12:40:41ZAntimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain10.1038/s41598-020-79302-12045-2322https://doaj.org/article/f9a653f806b144c595cad39dd44b791d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79302-1https://doaj.org/toc/2045-2322Abstract Clinical observations show that patients with anorexia nervosa (AN) are surprisingly free from infectious diseases. There is evidence from studies in Drosophila melanogaster that starvation leads to an increased expression of antimicrobial peptides (AMPs). AMPs are part of the innate immune system and protect human surfaces from colonization with pathogenic bacteria, viruses and fungi. We compared the expression of AMPs between patients with AN and healthy controls (HC) and investigated the influence of weight gain. Using a standardized skin rinsing method, quantitative determination of the AMPs psoriasin and RNase 7 was carried out by ELISA. Even though non-significant, effect sizes revealed slightly higher AMP concentrations in HC. After a mean weight gain of 2.0 body mass index points, the concentration of psoriasin on the forehead of patients with AN increased significantly. We could not confirm our hypotheses of higher AMP concentrations in patients with AN that decrease after weight gain. On the contrary, weight gain seems to be associated with increasing AMP concentrations.Marie-Christin BendixMichael StephanMariel NöhreWally Wünsch-LeiteritzHagen SchmidtGisa TiegsJürgen HarderMartina de ZwaanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie-Christin Bendix Michael Stephan Mariel Nöhre Wally Wünsch-Leiteritz Hagen Schmidt Gisa Tiegs Jürgen Harder Martina de Zwaan Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain
description	Abstract Clinical observations show that patients with anorexia nervosa (AN) are surprisingly free from infectious diseases. There is evidence from studies in Drosophila melanogaster that starvation leads to an increased expression of antimicrobial peptides (AMPs). AMPs are part of the innate immune system and protect human surfaces from colonization with pathogenic bacteria, viruses and fungi. We compared the expression of AMPs between patients with AN and healthy controls (HC) and investigated the influence of weight gain. Using a standardized skin rinsing method, quantitative determination of the AMPs psoriasin and RNase 7 was carried out by ELISA. Even though non-significant, effect sizes revealed slightly higher AMP concentrations in HC. After a mean weight gain of 2.0 body mass index points, the concentration of psoriasin on the forehead of patients with AN increased significantly. We could not confirm our hypotheses of higher AMP concentrations in patients with AN that decrease after weight gain. On the contrary, weight gain seems to be associated with increasing AMP concentrations.
format	article
author	Marie-Christin Bendix Michael Stephan Mariel Nöhre Wally Wünsch-Leiteritz Hagen Schmidt Gisa Tiegs Jürgen Harder Martina de Zwaan
author_facet	Marie-Christin Bendix Michael Stephan Mariel Nöhre Wally Wünsch-Leiteritz Hagen Schmidt Gisa Tiegs Jürgen Harder Martina de Zwaan
author_sort	Marie-Christin Bendix
title	Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain
title_short	Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain
title_full	Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain
title_fullStr	Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain
title_full_unstemmed	Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain
title_sort	antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f9a653f806b144c595cad39dd44b791d
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Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain

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