Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma

Abstract Glaucoma is a disease characterized by pathologic changes in inner retinal layers, which are comprised of retinal ganglion cells (RGCs). As retinal ganglion cells (RGCs) cross over other retinal neurons that are connected by synapses, it is meaningful to investigate the outer retinal change...

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Autores principales:	Eun Kyoung Kim, Hae-Young Lopilly Park, Chan Kee Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9a97a594fee4fb8aff63b3f0c4e075e
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spelling	oai:doaj.org-article:f9a97a594fee4fb8aff63b3f0c4e075e2021-12-02T11:51:04ZRelationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma10.1038/s41598-017-05282-42045-2322https://doaj.org/article/f9a97a594fee4fb8aff63b3f0c4e075e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05282-4https://doaj.org/toc/2045-2322Abstract Glaucoma is a disease characterized by pathologic changes in inner retinal layers, which are comprised of retinal ganglion cells (RGCs). As retinal ganglion cells (RGCs) cross over other retinal neurons that are connected by synapses, it is meaningful to investigate the outer retinal changes in glaucoma. We evaluated the association between thicknesses of segmented retinal layers in macular region and severity of visual field loss in open-angle glaucoma (OAG). This study involved 103 glaucomatous eyes. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL) thicknesses were measured at the macular level using the Spectral-domain optical coherence tomography with segmentation software. The functional losses were measured using 24-2 standard automated perimetry. Macular structure losses were positively correlated with functional loss for RNFL, GCL, and IPL (R = 0.550, 0.637, and 0.649, respectively, P < 0.001) and negatively correlated with INL (R = −0.295, P = 0.041). By multivariate regression analysis, INL thickness was significantly associated with visual field mean deviation (dB) and optic disc hemorrhage. These finding carefully suggest reactive responses of neuronal or glial cells located in the INL occur during glaucoma progression.Eun Kyoung KimHae-Young Lopilly ParkChan Kee ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eun Kyoung Kim Hae-Young Lopilly Park Chan Kee Park Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma
description	Abstract Glaucoma is a disease characterized by pathologic changes in inner retinal layers, which are comprised of retinal ganglion cells (RGCs). As retinal ganglion cells (RGCs) cross over other retinal neurons that are connected by synapses, it is meaningful to investigate the outer retinal changes in glaucoma. We evaluated the association between thicknesses of segmented retinal layers in macular region and severity of visual field loss in open-angle glaucoma (OAG). This study involved 103 glaucomatous eyes. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL) thicknesses were measured at the macular level using the Spectral-domain optical coherence tomography with segmentation software. The functional losses were measured using 24-2 standard automated perimetry. Macular structure losses were positively correlated with functional loss for RNFL, GCL, and IPL (R = 0.550, 0.637, and 0.649, respectively, P < 0.001) and negatively correlated with INL (R = −0.295, P = 0.041). By multivariate regression analysis, INL thickness was significantly associated with visual field mean deviation (dB) and optic disc hemorrhage. These finding carefully suggest reactive responses of neuronal or glial cells located in the INL occur during glaucoma progression.
format	article
author	Eun Kyoung Kim Hae-Young Lopilly Park Chan Kee Park
author_facet	Eun Kyoung Kim Hae-Young Lopilly Park Chan Kee Park
author_sort	Eun Kyoung Kim
title	Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma
title_short	Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma
title_full	Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma
title_fullStr	Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma
title_full_unstemmed	Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma
title_sort	relationship between retinal inner nuclear layer thickness and severity of visual field loss in glaucoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f9a97a594fee4fb8aff63b3f0c4e075e
work_keys_str_mv	AT eunkyoungkim relationshipbetweenretinalinnernuclearlayerthicknessandseverityofvisualfieldlossinglaucoma AT haeyounglopillypark relationshipbetweenretinalinnernuclearlayerthicknessandseverityofvisualfieldlossinglaucoma AT chankeepark relationshipbetweenretinalinnernuclearlayerthicknessandseverityofvisualfieldlossinglaucoma
_version_	1718395202310242304

Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma

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