Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training

Abstract To test the hypothesis that complexed trace mineral supplementation would increase antioxidant capacity and decrease muscle oxidative stress and damage in young horses entering an exercise training program, Quarter Horses (mean $$\pm$$ ± SD; 9.7 ± 0.7 mo) balanced by age, sex, and BW were a...

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Autores principales:	Christine M. Latham, Emily C. Dickson, Randi N. Owen, Connie K. Larson, Sarah H. White-Springer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9ab140480764aafb77db055dd3bbc1a
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spelling	oai:doaj.org-article:f9ab140480764aafb77db055dd3bbc1a2021-12-02T14:25:26ZComplexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training10.1038/s41598-021-86478-72045-2322https://doaj.org/article/f9ab140480764aafb77db055dd3bbc1a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86478-7https://doaj.org/toc/2045-2322Abstract To test the hypothesis that complexed trace mineral supplementation would increase antioxidant capacity and decrease muscle oxidative stress and damage in young horses entering an exercise training program, Quarter Horses (mean $$\pm$$ ± SD; 9.7 ± 0.7 mo) balanced by age, sex, and BW were assigned to receive complexed (CTM; n = 8) or inorganic (INORG; n = 8) trace minerals at -12 week relative to this study. Blood and muscle samples were collected before (week 0) and after 12 week of light exercise training surrounding a 1.5-h trailer stressor. Muscle glutathione peroxidase (GPx) activity was higher for CTM than INORG horses (P ≤ 0.0003) throughout the study. Following both trailer stressors, serum creatine kinase increased (P < 0.0001) and remained elevated through 24 h post-trailering (P < 0.0001). At week 0, muscle malondialdehyde, expression of superoxide dismutase 2, and whole blood GPx activity increased (P $$\le$$ ≤ 0.003) following trailering but trailering did not affect these measures at week 12. Young horses supplemented with CTM had higher muscle GPx activity than horses receiving INORG, but CTM did not affect damage markers following a stressor. Dietary CTM may be useful for improving antioxidant capacity during exercise training in young equine athletes.Christine M. LathamEmily C. DicksonRandi N. OwenConnie K. LarsonSarah H. White-SpringerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christine M. Latham Emily C. Dickson Randi N. Owen Connie K. Larson Sarah H. White-Springer Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training
description	Abstract To test the hypothesis that complexed trace mineral supplementation would increase antioxidant capacity and decrease muscle oxidative stress and damage in young horses entering an exercise training program, Quarter Horses (mean $$\pm$$ ± SD; 9.7 ± 0.7 mo) balanced by age, sex, and BW were assigned to receive complexed (CTM; n = 8) or inorganic (INORG; n = 8) trace minerals at -12 week relative to this study. Blood and muscle samples were collected before (week 0) and after 12 week of light exercise training surrounding a 1.5-h trailer stressor. Muscle glutathione peroxidase (GPx) activity was higher for CTM than INORG horses (P ≤ 0.0003) throughout the study. Following both trailer stressors, serum creatine kinase increased (P < 0.0001) and remained elevated through 24 h post-trailering (P < 0.0001). At week 0, muscle malondialdehyde, expression of superoxide dismutase 2, and whole blood GPx activity increased (P $$\le$$ ≤ 0.003) following trailering but trailering did not affect these measures at week 12. Young horses supplemented with CTM had higher muscle GPx activity than horses receiving INORG, but CTM did not affect damage markers following a stressor. Dietary CTM may be useful for improving antioxidant capacity during exercise training in young equine athletes.
format	article
author	Christine M. Latham Emily C. Dickson Randi N. Owen Connie K. Larson Sarah H. White-Springer
author_facet	Christine M. Latham Emily C. Dickson Randi N. Owen Connie K. Larson Sarah H. White-Springer
author_sort	Christine M. Latham
title	Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training
title_short	Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training
title_full	Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training
title_fullStr	Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training
title_full_unstemmed	Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training
title_sort	complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f9ab140480764aafb77db055dd3bbc1a
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Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training

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