Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect

Hayley Nehoff,1 Neha N Parayath,1 Laura Domanovitch,1 Sebastien Taurin,1 Khaled Greish1,2 1Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; 2Department of Oncology, Faculty of Medicine, Suez Canal University, Egypt Abstract: The growing research interest in na...

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Autores principales:	Nehoff H, Parayath NN, Domnanovich L, Taurin S, Greish K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f9abb3210de549b4a1a58d3db4c5e591
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spelling	oai:doaj.org-article:f9abb3210de549b4a1a58d3db4c5e5912021-12-02T07:37:00ZNanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect1178-2013https://doaj.org/article/f9abb3210de549b4a1a58d3db4c5e5912014-05-01T00:00:00Zhttp://www.dovepress.com/nanomedicine-for-drug-targeting-strategies-beyond-the-enhanced-permeab-a16952https://doaj.org/toc/1178-2013 Hayley Nehoff,1 Neha N Parayath,1 Laura Domanovitch,1 Sebastien Taurin,1 Khaled Greish1,2 1Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; 2Department of Oncology, Faculty of Medicine, Suez Canal University, Egypt Abstract: The growing research interest in nanomedicine for the treatment of cancer and inflammatory-related pathologies is yielding encouraging results. Unfortunately, enthusiasm is tempered by the limited specificity of the enhanced permeability and retention effect. Factors such as lack of cellular specificity, low vascular density, and early release of active agents prior to reaching their target contribute to the limitations of the enhanced permeability and retention effect. However, improved nanomedicine designs are creating opportunities to overcome these problems. In this review, we present examples of the advances made in this field and endeavor to highlight the potential of these emerging technologies to improve targeting of nanomedicine to specific pathological cells and tissues. Keywords: nanomedicine, permeability and retention effect, tissue targeting, cancer treatment, inflammationNehoff HParayath NNDomnanovich LTaurin SGreish KDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2539-2555 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Nehoff H Parayath NN Domnanovich L Taurin S Greish K Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect
description	Hayley Nehoff,1 Neha N Parayath,1 Laura Domanovitch,1 Sebastien Taurin,1 Khaled Greish1,2 1Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; 2Department of Oncology, Faculty of Medicine, Suez Canal University, Egypt Abstract: The growing research interest in nanomedicine for the treatment of cancer and inflammatory-related pathologies is yielding encouraging results. Unfortunately, enthusiasm is tempered by the limited specificity of the enhanced permeability and retention effect. Factors such as lack of cellular specificity, low vascular density, and early release of active agents prior to reaching their target contribute to the limitations of the enhanced permeability and retention effect. However, improved nanomedicine designs are creating opportunities to overcome these problems. In this review, we present examples of the advances made in this field and endeavor to highlight the potential of these emerging technologies to improve targeting of nanomedicine to specific pathological cells and tissues. Keywords: nanomedicine, permeability and retention effect, tissue targeting, cancer treatment, inflammation
format	article
author	Nehoff H Parayath NN Domnanovich L Taurin S Greish K
author_facet	Nehoff H Parayath NN Domnanovich L Taurin S Greish K
author_sort	Nehoff H
title	Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect
title_short	Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect
title_full	Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect
title_fullStr	Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect
title_full_unstemmed	Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect
title_sort	nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/f9abb3210de549b4a1a58d3db4c5e591
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Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect

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