Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex

Lizhe Zhu et al. use a quasi Markov State Model built from extensive molecular dynamics simulations to elucidate the dynamics of RISC-mRNA interactions. Their results provide further insight on how a target nucleotide is positioned before recognition by Argonaute.

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Autores principales:	Lizhe Zhu, Hanlun Jiang, Siqin Cao, Ilona Christy Unarta, Xin Gao, Xuhui Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f9b08be56b81469197c788250c9a00d7
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spelling	oai:doaj.org-article:f9b08be56b81469197c788250c9a00d72021-12-05T12:08:10ZCritical role of backbone coordination in the mRNA recognition by RNA induced silencing complex10.1038/s42003-021-02822-72399-3642https://doaj.org/article/f9b08be56b81469197c788250c9a00d72021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02822-7https://doaj.org/toc/2399-3642Lizhe Zhu et al. use a quasi Markov State Model built from extensive molecular dynamics simulations to elucidate the dynamics of RISC-mRNA interactions. Their results provide further insight on how a target nucleotide is positioned before recognition by Argonaute.Lizhe ZhuHanlun JiangSiqin CaoIlona Christy UnartaXin GaoXuhui HuangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lizhe Zhu Hanlun Jiang Siqin Cao Ilona Christy Unarta Xin Gao Xuhui Huang Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex
description	Lizhe Zhu et al. use a quasi Markov State Model built from extensive molecular dynamics simulations to elucidate the dynamics of RISC-mRNA interactions. Their results provide further insight on how a target nucleotide is positioned before recognition by Argonaute.
format	article
author	Lizhe Zhu Hanlun Jiang Siqin Cao Ilona Christy Unarta Xin Gao Xuhui Huang
author_facet	Lizhe Zhu Hanlun Jiang Siqin Cao Ilona Christy Unarta Xin Gao Xuhui Huang
author_sort	Lizhe Zhu
title	Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex
title_short	Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex
title_full	Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex
title_fullStr	Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex
title_full_unstemmed	Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex
title_sort	critical role of backbone coordination in the mrna recognition by rna induced silencing complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f9b08be56b81469197c788250c9a00d7
work_keys_str_mv	AT lizhezhu criticalroleofbackbonecoordinationinthemrnarecognitionbyrnainducedsilencingcomplex AT hanlunjiang criticalroleofbackbonecoordinationinthemrnarecognitionbyrnainducedsilencingcomplex AT siqincao criticalroleofbackbonecoordinationinthemrnarecognitionbyrnainducedsilencingcomplex AT ilonachristyunarta criticalroleofbackbonecoordinationinthemrnarecognitionbyrnainducedsilencingcomplex AT xingao criticalroleofbackbonecoordinationinthemrnarecognitionbyrnainducedsilencingcomplex AT xuhuihuang criticalroleofbackbonecoordinationinthemrnarecognitionbyrnainducedsilencingcomplex
_version_	1718372230711214080

Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex

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