PRODH polymorphisms, cortical volumes and thickness in schizophrenia.
Schizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder. Therefore, our study investigates the effects of 12 polymorphisms of PRODH on schizophrenia and its phenotypes. To further evaluate the roles...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f9b52f005058451ca42fb9b03a07d468 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f9b52f005058451ca42fb9b03a07d468 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f9b52f005058451ca42fb9b03a07d4682021-11-18T08:34:13ZPRODH polymorphisms, cortical volumes and thickness in schizophrenia.1932-620310.1371/journal.pone.0087686https://doaj.org/article/f9b52f005058451ca42fb9b03a07d4682014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498354/?tool=EBIhttps://doaj.org/toc/1932-6203Schizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder. Therefore, our study investigates the effects of 12 polymorphisms of PRODH on schizophrenia and its phenotypes. To further evaluate the roles of the associated variants in the disorder, we have conducted magnetic resonance imaging (MRI) scans to assess cortical volumes and thicknesses. A total of 192 patients were evaluated using the Structured Clinical Interview for DSM-IV (SCID), Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale, Global Assessment of Functioning (GAF) and Clinical Global Impression (CGI) instruments. The study included 179 controls paired by age and gender. The samples were genotyped using the real-time polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP)-PCR and Sanger sequencing methods. A sample of 138 patients and 34 healthy controls underwent MRI scans. One polymorphism was associated with schizophrenia (rs2904552), with the G-allele more frequent in patients than in controls. This polymorphism is likely functional, as predicted by PolyPhen and SIFT, but it was not associated with brain morphology in our study. In summary, we report a functional PRODH variant associated with schizophrenia that may have a neurochemical impact, altering brain function, but is not responsible for the cortical reductions found in the disorder.Vanessa K OtaFernanda T BelluccoAry GadelhaMarcos L SantoroCristiano NotoDenise M ChristofoliniIdaiane B AssunçãoKaren M YamadaAndrea K Ribeiro-dos-SantosSidney SantosJair J MariMarília A C SmithMaria I MelaragnoRodrigo A BressanJoão R SatoAndrea P JackowskiSintia I BelangeroPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e87686 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Vanessa K Ota Fernanda T Bellucco Ary Gadelha Marcos L Santoro Cristiano Noto Denise M Christofolini Idaiane B Assunção Karen M Yamada Andrea K Ribeiro-dos-Santos Sidney Santos Jair J Mari Marília A C Smith Maria I Melaragno Rodrigo A Bressan João R Sato Andrea P Jackowski Sintia I Belangero PRODH polymorphisms, cortical volumes and thickness in schizophrenia. |
| description |
Schizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder. Therefore, our study investigates the effects of 12 polymorphisms of PRODH on schizophrenia and its phenotypes. To further evaluate the roles of the associated variants in the disorder, we have conducted magnetic resonance imaging (MRI) scans to assess cortical volumes and thicknesses. A total of 192 patients were evaluated using the Structured Clinical Interview for DSM-IV (SCID), Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale, Global Assessment of Functioning (GAF) and Clinical Global Impression (CGI) instruments. The study included 179 controls paired by age and gender. The samples were genotyped using the real-time polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP)-PCR and Sanger sequencing methods. A sample of 138 patients and 34 healthy controls underwent MRI scans. One polymorphism was associated with schizophrenia (rs2904552), with the G-allele more frequent in patients than in controls. This polymorphism is likely functional, as predicted by PolyPhen and SIFT, but it was not associated with brain morphology in our study. In summary, we report a functional PRODH variant associated with schizophrenia that may have a neurochemical impact, altering brain function, but is not responsible for the cortical reductions found in the disorder. |
| format |
article |
| author |
Vanessa K Ota Fernanda T Bellucco Ary Gadelha Marcos L Santoro Cristiano Noto Denise M Christofolini Idaiane B Assunção Karen M Yamada Andrea K Ribeiro-dos-Santos Sidney Santos Jair J Mari Marília A C Smith Maria I Melaragno Rodrigo A Bressan João R Sato Andrea P Jackowski Sintia I Belangero |
| author_facet |
Vanessa K Ota Fernanda T Bellucco Ary Gadelha Marcos L Santoro Cristiano Noto Denise M Christofolini Idaiane B Assunção Karen M Yamada Andrea K Ribeiro-dos-Santos Sidney Santos Jair J Mari Marília A C Smith Maria I Melaragno Rodrigo A Bressan João R Sato Andrea P Jackowski Sintia I Belangero |
| author_sort |
Vanessa K Ota |
| title |
PRODH polymorphisms, cortical volumes and thickness in schizophrenia. |
| title_short |
PRODH polymorphisms, cortical volumes and thickness in schizophrenia. |
| title_full |
PRODH polymorphisms, cortical volumes and thickness in schizophrenia. |
| title_fullStr |
PRODH polymorphisms, cortical volumes and thickness in schizophrenia. |
| title_full_unstemmed |
PRODH polymorphisms, cortical volumes and thickness in schizophrenia. |
| title_sort |
prodh polymorphisms, cortical volumes and thickness in schizophrenia. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/f9b52f005058451ca42fb9b03a07d468 |
| work_keys_str_mv |
AT vanessakota prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT fernandatbellucco prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT arygadelha prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT marcoslsantoro prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT cristianonoto prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT denisemchristofolini prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT idaianebassuncao prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT karenmyamada prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT andreakribeirodossantos prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT sidneysantos prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT jairjmari prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT mariliaacsmith prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT mariaimelaragno prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT rodrigoabressan prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT joaorsato prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT andreapjackowski prodhpolymorphismscorticalvolumesandthicknessinschizophrenia AT sintiaibelangero prodhpolymorphismscorticalvolumesandthicknessinschizophrenia |
| _version_ |
1718421659462926336 |