Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice

Abstract The metabolic syndrome is a cluster of conditions that increase an individual's risk of developing diseases. Being physically active throughout life is known to reduce the prevalence and onset of some aspects of the metabolic syndrome. Furthermore, previous studies have demonstrated th...

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Autores principales:	Timothy M. Moore, Anthony Terrazas, Alexander R. Strumwasser, Amanda J. Lin, Xiaopeng Zhu, Akshay T. S. Anand, Christina Q. Nguyen, Linsey Stiles, Frode Norheim, Jennifer M. Lang, Simon T. Hui, Lorraine P. Turcotte, Zhenqi Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	exercise LDLR metabolic syndrome microbiome obesity Physiology QP1-981
Acceso en línea:	https://doaj.org/article/f9b6c1e808ee4704b4e5315048483677
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spelling	oai:doaj.org-article:f9b6c1e808ee4704b4e53150484836772021-11-15T09:54:40ZEffect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice2051-817X10.14814/phy2.15068https://doaj.org/article/f9b6c1e808ee4704b4e53150484836772021-11-01T00:00:00Zhttps://doi.org/10.14814/phy2.15068https://doaj.org/toc/2051-817XAbstract The metabolic syndrome is a cluster of conditions that increase an individual's risk of developing diseases. Being physically active throughout life is known to reduce the prevalence and onset of some aspects of the metabolic syndrome. Furthermore, previous studies have demonstrated that an individual's gut microbiome composition has a large influence on several aspects of the metabolic syndrome. However, the mechanism(s) by which physical activity may improve metabolic health are not well understood. We sought to determine if endurance exercise is sufficient to prevent or ameliorate the development of the metabolic syndrome and its associated diseases. We also analyzed the impact of physical activity under metabolic syndrome progression upon the gut microbiome composition. Utilizing whole‐body low‐density lipoprotein receptor (LDLR) knockout mice on a “Western Diet,” we show that long‐term exercise acts favorably upon glucose tolerance, adiposity, and liver lipids. Exercise increased mitochondrial abundance in skeletal muscle but did not reduce liver fibrosis, aortic lesion area, or plasma lipids. Lastly, we observed several changes in gut bacteria and their novel associations with metabolic parameters of clinical importance. Altogether, our results indicate that exercise can ameliorate some aspects of the metabolic syndrome progression and alter the gut microbiome composition.Timothy M. MooreAnthony TerrazasAlexander R. StrumwasserAmanda J. LinXiaopeng ZhuAkshay T. S. AnandChristina Q. NguyenLinsey StilesFrode NorheimJennifer M. LangSimon T. HuiLorraine P. TurcotteZhenqi ZhouWileyarticleexerciseLDLRmetabolic syndromemicrobiomeobesityPhysiologyQP1-981ENPhysiological Reports, Vol 9, Iss 21, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exercise LDLR metabolic syndrome microbiome obesity Physiology QP1-981
spellingShingle	exercise LDLR metabolic syndrome microbiome obesity Physiology QP1-981 Timothy M. Moore Anthony Terrazas Alexander R. Strumwasser Amanda J. Lin Xiaopeng Zhu Akshay T. S. Anand Christina Q. Nguyen Linsey Stiles Frode Norheim Jennifer M. Lang Simon T. Hui Lorraine P. Turcotte Zhenqi Zhou Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice
description	Abstract The metabolic syndrome is a cluster of conditions that increase an individual's risk of developing diseases. Being physically active throughout life is known to reduce the prevalence and onset of some aspects of the metabolic syndrome. Furthermore, previous studies have demonstrated that an individual's gut microbiome composition has a large influence on several aspects of the metabolic syndrome. However, the mechanism(s) by which physical activity may improve metabolic health are not well understood. We sought to determine if endurance exercise is sufficient to prevent or ameliorate the development of the metabolic syndrome and its associated diseases. We also analyzed the impact of physical activity under metabolic syndrome progression upon the gut microbiome composition. Utilizing whole‐body low‐density lipoprotein receptor (LDLR) knockout mice on a “Western Diet,” we show that long‐term exercise acts favorably upon glucose tolerance, adiposity, and liver lipids. Exercise increased mitochondrial abundance in skeletal muscle but did not reduce liver fibrosis, aortic lesion area, or plasma lipids. Lastly, we observed several changes in gut bacteria and their novel associations with metabolic parameters of clinical importance. Altogether, our results indicate that exercise can ameliorate some aspects of the metabolic syndrome progression and alter the gut microbiome composition.
format	article
author	Timothy M. Moore Anthony Terrazas Alexander R. Strumwasser Amanda J. Lin Xiaopeng Zhu Akshay T. S. Anand Christina Q. Nguyen Linsey Stiles Frode Norheim Jennifer M. Lang Simon T. Hui Lorraine P. Turcotte Zhenqi Zhou
author_facet	Timothy M. Moore Anthony Terrazas Alexander R. Strumwasser Amanda J. Lin Xiaopeng Zhu Akshay T. S. Anand Christina Q. Nguyen Linsey Stiles Frode Norheim Jennifer M. Lang Simon T. Hui Lorraine P. Turcotte Zhenqi Zhou
author_sort	Timothy M. Moore
title	Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice
title_short	Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice
title_full	Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice
title_fullStr	Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice
title_full_unstemmed	Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice
title_sort	effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/f9b6c1e808ee4704b4e5315048483677
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Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice

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