Arginine methylation of METTL14 promotes RNA N 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells

The methyltransferase complex of METTL3-METTL14-WTAP is responsible for m6A modification on RNA. Here the authors report that METTL14 arginine 255 (R255) is methylated by PRMT1 and this modification increases interaction of METTL3/METTL14 interaction with WTAP and substrate RNA, promoting m6A methyl...

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Autores principales:	Xiaona Liu, Hailong Wang, Xueya Zhao, Qizhi Luo, Qingwen Wang, Kaifen Tan, Zihan Wang, Jia Jiang, Jinru Cui, Enhui Du, Linjian Xia, Wenyi Du, Dahua Chen, Laixin Xia, Shan Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f9b963d6c18f4565b0a8d445e7b3a86f
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spelling	oai:doaj.org-article:f9b963d6c18f4565b0a8d445e7b3a86f2021-12-02T17:40:00ZArginine methylation of METTL14 promotes RNA N 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells10.1038/s41467-021-24035-62041-1723https://doaj.org/article/f9b963d6c18f4565b0a8d445e7b3a86f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24035-6https://doaj.org/toc/2041-1723The methyltransferase complex of METTL3-METTL14-WTAP is responsible for m6A modification on RNA. Here the authors report that METTL14 arginine 255 (R255) is methylated by PRMT1 and this modification increases interaction of METTL3/METTL14 interaction with WTAP and substrate RNA, promoting m6A methylation activity of the complex.Xiaona LiuHailong WangXueya ZhaoQizhi LuoQingwen WangKaifen TanZihan WangJia JiangJinru CuiEnhui DuLinjian XiaWenyi DuDahua ChenLaixin XiaShan XiaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaona Liu Hailong Wang Xueya Zhao Qizhi Luo Qingwen Wang Kaifen Tan Zihan Wang Jia Jiang Jinru Cui Enhui Du Linjian Xia Wenyi Du Dahua Chen Laixin Xia Shan Xiao Arginine methylation of METTL14 promotes RNA N 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
description	The methyltransferase complex of METTL3-METTL14-WTAP is responsible for m6A modification on RNA. Here the authors report that METTL14 arginine 255 (R255) is methylated by PRMT1 and this modification increases interaction of METTL3/METTL14 interaction with WTAP and substrate RNA, promoting m6A methylation activity of the complex.
format	article
author	Xiaona Liu Hailong Wang Xueya Zhao Qizhi Luo Qingwen Wang Kaifen Tan Zihan Wang Jia Jiang Jinru Cui Enhui Du Linjian Xia Wenyi Du Dahua Chen Laixin Xia Shan Xiao
author_facet	Xiaona Liu Hailong Wang Xueya Zhao Qizhi Luo Qingwen Wang Kaifen Tan Zihan Wang Jia Jiang Jinru Cui Enhui Du Linjian Xia Wenyi Du Dahua Chen Laixin Xia Shan Xiao
author_sort	Xiaona Liu
title	Arginine methylation of METTL14 promotes RNA N 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
title_short	Arginine methylation of METTL14 promotes RNA N 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
title_full	Arginine methylation of METTL14 promotes RNA N 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
title_fullStr	Arginine methylation of METTL14 promotes RNA N 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
title_full_unstemmed	Arginine methylation of METTL14 promotes RNA N 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
title_sort	arginine methylation of mettl14 promotes rna n 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f9b963d6c18f4565b0a8d445e7b3a86f
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_version_	1718379801601900544

Arginine methylation of METTL14 promotes RNA N 6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells

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