Review of the clinical evidence for interferon β 1a (Rebif®) in the treatment of multiple sclerosis
Francesco Manfredonia1, Livia Pasquali1, Angela Dardano2, Alfonso Iudice1, Luigi Murri1, Fabio Monzani21Department of Neuroscience and 2Department of Internal Medicine, University of Pisa, Pisa, ItalyAbstract: Interferon (INF) β 1a 22 or 44 µg (Rebif®) administ...
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Dove Medical Press
2008
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oai:doaj.org-article:f9ba7fc011e5483988eb9c66774311ef2021-12-02T00:52:30ZReview of the clinical evidence for interferon β 1a (Rebif®) in the treatment of multiple sclerosis1176-63281178-2021https://doaj.org/article/f9ba7fc011e5483988eb9c66774311ef2008-04-01T00:00:00Zhttp://www.dovepress.com/review-of-the-clinical-evidence-for-interferon-beta-1a-rebifsupregsup--a1021https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Francesco Manfredonia1, Livia Pasquali1, Angela Dardano2, Alfonso Iudice1, Luigi Murri1, Fabio Monzani21Department of Neuroscience and 2Department of Internal Medicine, University of Pisa, Pisa, ItalyAbstract: Interferon (INF) β 1a 22 or 44 µg (Rebif®) administered s.c. 3 times a week (t.i.w) is a well established immunomodulating treatment for relapsing remitting multiple sclerosis (RRMS). This review focuses on its mechanisms of action, evidence of efficacy, safety, and tolerability. Several pharmacodynamic properties explain the immunomodulatory actions of INF β 1a 22 or 44 µg s.c. t.i.w. Pivotal trials and post-marketing studies proved that the drug is effective in reducing disease activity and likely in slowing disease progression. Head-to-head comparative studies with other marketed INFs β in RRMS suggested a better therapeutic response associated with higher doses and frequency of administration of Rebif®. Additional evidence indicated a beneficial effect of INF β 1a in patients with clinically isolated syndromes (CIS) suggestive of MS, as treatment reduced time to conversion to clinically definite (CD) disease. Further, although the drug did not prove to slow time to progression there were benefits on relapse- and MRI-related secondary outcome measures in secondary progressive (SP) MS. Pivotal trials, their cross-over extensions, and post-marketing studies consistently showed that INF β 1a 22 or 44 µg s.c. t.i.w. is safe and well tolerated, as adverse drug reactions are usually mild and manageable.Keywords: interferon β 1a, multiple sclerosis, review, clinical trials, post-marketing studies Francesco ManfredoniaLivia PasqualiAngela DardanoAlfonso IudiceLuigi MurriFabio MonzaniDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 2, Pp 321-336 (2008) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Francesco Manfredonia Livia Pasquali Angela Dardano Alfonso Iudice Luigi Murri Fabio Monzani Review of the clinical evidence for interferon β 1a (Rebif®) in the treatment of multiple sclerosis |
| description |
Francesco Manfredonia1, Livia Pasquali1, Angela Dardano2, Alfonso Iudice1, Luigi Murri1, Fabio Monzani21Department of Neuroscience and 2Department of Internal Medicine, University of Pisa, Pisa, ItalyAbstract: Interferon (INF) β 1a 22 or 44 µg (Rebif®) administered s.c. 3 times a week (t.i.w) is a well established immunomodulating treatment for relapsing remitting multiple sclerosis (RRMS). This review focuses on its mechanisms of action, evidence of efficacy, safety, and tolerability. Several pharmacodynamic properties explain the immunomodulatory actions of INF β 1a 22 or 44 µg s.c. t.i.w. Pivotal trials and post-marketing studies proved that the drug is effective in reducing disease activity and likely in slowing disease progression. Head-to-head comparative studies with other marketed INFs β in RRMS suggested a better therapeutic response associated with higher doses and frequency of administration of Rebif®. Additional evidence indicated a beneficial effect of INF β 1a in patients with clinically isolated syndromes (CIS) suggestive of MS, as treatment reduced time to conversion to clinically definite (CD) disease. Further, although the drug did not prove to slow time to progression there were benefits on relapse- and MRI-related secondary outcome measures in secondary progressive (SP) MS. Pivotal trials, their cross-over extensions, and post-marketing studies consistently showed that INF β 1a 22 or 44 µg s.c. t.i.w. is safe and well tolerated, as adverse drug reactions are usually mild and manageable.Keywords: interferon β 1a, multiple sclerosis, review, clinical trials, post-marketing studies |
| format |
article |
| author |
Francesco Manfredonia Livia Pasquali Angela Dardano Alfonso Iudice Luigi Murri Fabio Monzani |
| author_facet |
Francesco Manfredonia Livia Pasquali Angela Dardano Alfonso Iudice Luigi Murri Fabio Monzani |
| author_sort |
Francesco Manfredonia |
| title |
Review of the clinical evidence for interferon β 1a (Rebif®) in the treatment of multiple sclerosis |
| title_short |
Review of the clinical evidence for interferon β 1a (Rebif®) in the treatment of multiple sclerosis |
| title_full |
Review of the clinical evidence for interferon β 1a (Rebif®) in the treatment of multiple sclerosis |
| title_fullStr |
Review of the clinical evidence for interferon β 1a (Rebif®) in the treatment of multiple sclerosis |
| title_full_unstemmed |
Review of the clinical evidence for interferon β 1a (Rebif®) in the treatment of multiple sclerosis |
| title_sort |
review of the clinical evidence for interferon β 1a (rebif®) in the treatment of multiple sclerosis |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/f9ba7fc011e5483988eb9c66774311ef |
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