The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones

The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones

R2TP is an HSP90 co-chaperone composed of an RPAP3-PIH1D1 heterodimer, which binds two essential AAA+ ATPases RUVBL1/RUVBL2. Here authors use a structural approach to study RPAP3 and find an RPAP3-like protein (SPAG1) which also forms a co-chaperone complex with PIH1D2 and RUVBL1/2 enriched in testi...

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Autores principales: Chloé Maurizy, Marc Quinternet, Yoann Abel, Céline Verheggen, Paulo E. Santo, Maxime Bourguet, Ana C.F. Paiva, Benoît Bragantini, Marie-Eve Chagot, Marie-Cécile Robert, Claire Abeza, Philippe Fabre, Philippe Fort, Franck Vandermoere, Pedro M.F. Sousa, Jean-Christophe Rain, Bruno Charpentier, Sarah Cianférani, Tiago M. Bandeiras, Bérengère Pradet-Balade, Xavier Manival, Edouard Bertrand
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f9bce095aa2a4c49a49a7a66e4c6ecf6
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spelling oai:doaj.org-article:f9bce095aa2a4c49a49a7a66e4c6ecf62021-12-02T14:41:28ZThe RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones10.1038/s41467-018-04431-12041-1723https://doaj.org/article/f9bce095aa2a4c49a49a7a66e4c6ecf62018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04431-1https://doaj.org/toc/2041-1723R2TP is an HSP90 co-chaperone composed of an RPAP3-PIH1D1 heterodimer, which binds two essential AAA+ ATPases RUVBL1/RUVBL2. Here authors use a structural approach to study RPAP3 and find an RPAP3-like protein (SPAG1) which also forms a co-chaperone complex with PIH1D2 and RUVBL1/2 enriched in testis.Chloé MaurizyMarc QuinternetYoann AbelCéline VerheggenPaulo E. SantoMaxime BourguetAna C.F. PaivaBenoît BragantiniMarie-Eve ChagotMarie-Cécile RobertClaire AbezaPhilippe FabrePhilippe FortFranck VandermoerePedro M.F. SousaJean-Christophe RainBruno CharpentierSarah CianféraniTiago M. BandeirasBérengère Pradet-BaladeXavier ManivalEdouard BertrandNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chloé Maurizy
Marc Quinternet
Yoann Abel
Céline Verheggen
Paulo E. Santo
Maxime Bourguet
Ana C.F. Paiva
Benoît Bragantini
Marie-Eve Chagot
Marie-Cécile Robert
Claire Abeza
Philippe Fabre
Philippe Fort
Franck Vandermoere
Pedro M.F. Sousa
Jean-Christophe Rain
Bruno Charpentier
Sarah Cianférani
Tiago M. Bandeiras
Bérengère Pradet-Balade
Xavier Manival
Edouard Bertrand
The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones
description R2TP is an HSP90 co-chaperone composed of an RPAP3-PIH1D1 heterodimer, which binds two essential AAA+ ATPases RUVBL1/RUVBL2. Here authors use a structural approach to study RPAP3 and find an RPAP3-like protein (SPAG1) which also forms a co-chaperone complex with PIH1D2 and RUVBL1/2 enriched in testis.
format article
author Chloé Maurizy
Marc Quinternet
Yoann Abel
Céline Verheggen
Paulo E. Santo
Maxime Bourguet
Ana C.F. Paiva
Benoît Bragantini
Marie-Eve Chagot
Marie-Cécile Robert
Claire Abeza
Philippe Fabre
Philippe Fort
Franck Vandermoere
Pedro M.F. Sousa
Jean-Christophe Rain
Bruno Charpentier
Sarah Cianférani
Tiago M. Bandeiras
Bérengère Pradet-Balade
Xavier Manival
Edouard Bertrand
author_facet Chloé Maurizy
Marc Quinternet
Yoann Abel
Céline Verheggen
Paulo E. Santo
Maxime Bourguet
Ana C.F. Paiva
Benoît Bragantini
Marie-Eve Chagot
Marie-Cécile Robert
Claire Abeza
Philippe Fabre
Philippe Fort
Franck Vandermoere
Pedro M.F. Sousa
Jean-Christophe Rain
Bruno Charpentier
Sarah Cianférani
Tiago M. Bandeiras
Bérengère Pradet-Balade
Xavier Manival
Edouard Bertrand
author_sort Chloé Maurizy
title The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones
title_short The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones
title_full The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones
title_fullStr The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones
title_full_unstemmed The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones
title_sort rpap3-cterminal domain identifies r2tp-like quaternary chaperones
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f9bce095aa2a4c49a49a7a66e4c6ecf6
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