Inhibition Within the Lateral Habenula—Implications for Affective Disorders

The lateral habenula (LHb) is a key brain region implicated in the pathology of major depressive disorder (MDD). Specifically, excitatory LHb neurons are known to be hyperactive in MDD, thus resulting in a greater excitatory output mainly to downstream inhibitory neurons in the rostromedial tegmenta...

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Autores principales:	Jack F. Webster, Salvatore Lecca, Christian Wozny
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lateral habenula major depressive disorder inhibition local inhibitory interneurons inhibitory afferents Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f9be1212b2054d0c9998a88a309178e3
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spelling	oai:doaj.org-article:f9be1212b2054d0c9998a88a309178e32021-12-01T07:00:21ZInhibition Within the Lateral Habenula—Implications for Affective Disorders1662-515310.3389/fnbeh.2021.786011https://doaj.org/article/f9be1212b2054d0c9998a88a309178e32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.786011/fullhttps://doaj.org/toc/1662-5153The lateral habenula (LHb) is a key brain region implicated in the pathology of major depressive disorder (MDD). Specifically, excitatory LHb neurons are known to be hyperactive in MDD, thus resulting in a greater excitatory output mainly to downstream inhibitory neurons in the rostromedial tegmental nucleus. This likely results in suppression of downstream dopaminergic ventral tegmental area neurons, therefore, resulting in an overall reduction in reward signalling. In line with this, increasing evidence implicates aberrant inhibitory signalling onto LHb neurons as a co-causative factor in MDD, likely as a result of disinhibition of excitatory neurons. Consistently, growing evidence now suggests that normalising inhibitory signalling within the LHb may be a potential therapeutic strategy for MDD. Despite these recent advances, however, the exact pharmacological and neural circuit mechanisms which control inhibitory signalling within the LHb are still incompletely understood. Thus, in this review article, we aim to provide an up-to-date summary of the current state of knowledge of the mechanisms by which inhibitory signalling is processed within the LHb, with a view of exploring how this may be targeted as a future therapy for MDD.Jack F. WebsterSalvatore LeccaChristian WoznyChristian WoznyFrontiers Media S.A.articlelateral habenulamajor depressive disorderinhibitionlocal inhibitory interneuronsinhibitory afferentsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lateral habenula major depressive disorder inhibition local inhibitory interneurons inhibitory afferents Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	lateral habenula major depressive disorder inhibition local inhibitory interneurons inhibitory afferents Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jack F. Webster Salvatore Lecca Christian Wozny Christian Wozny Inhibition Within the Lateral Habenula—Implications for Affective Disorders
description	The lateral habenula (LHb) is a key brain region implicated in the pathology of major depressive disorder (MDD). Specifically, excitatory LHb neurons are known to be hyperactive in MDD, thus resulting in a greater excitatory output mainly to downstream inhibitory neurons in the rostromedial tegmental nucleus. This likely results in suppression of downstream dopaminergic ventral tegmental area neurons, therefore, resulting in an overall reduction in reward signalling. In line with this, increasing evidence implicates aberrant inhibitory signalling onto LHb neurons as a co-causative factor in MDD, likely as a result of disinhibition of excitatory neurons. Consistently, growing evidence now suggests that normalising inhibitory signalling within the LHb may be a potential therapeutic strategy for MDD. Despite these recent advances, however, the exact pharmacological and neural circuit mechanisms which control inhibitory signalling within the LHb are still incompletely understood. Thus, in this review article, we aim to provide an up-to-date summary of the current state of knowledge of the mechanisms by which inhibitory signalling is processed within the LHb, with a view of exploring how this may be targeted as a future therapy for MDD.
format	article
author	Jack F. Webster Salvatore Lecca Christian Wozny Christian Wozny
author_facet	Jack F. Webster Salvatore Lecca Christian Wozny Christian Wozny
author_sort	Jack F. Webster
title	Inhibition Within the Lateral Habenula—Implications for Affective Disorders
title_short	Inhibition Within the Lateral Habenula—Implications for Affective Disorders
title_full	Inhibition Within the Lateral Habenula—Implications for Affective Disorders
title_fullStr	Inhibition Within the Lateral Habenula—Implications for Affective Disorders
title_full_unstemmed	Inhibition Within the Lateral Habenula—Implications for Affective Disorders
title_sort	inhibition within the lateral habenula—implications for affective disorders
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f9be1212b2054d0c9998a88a309178e3
work_keys_str_mv	AT jackfwebster inhibitionwithinthelateralhabenulaimplicationsforaffectivedisorders AT salvatorelecca inhibitionwithinthelateralhabenulaimplicationsforaffectivedisorders AT christianwozny inhibitionwithinthelateralhabenulaimplicationsforaffectivedisorders AT christianwozny inhibitionwithinthelateralhabenulaimplicationsforaffectivedisorders
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Inhibition Within the Lateral Habenula—Implications for Affective Disorders

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