Tumor suppressor p53 regulates intestinal type 2 immunity

P53 is a well-known tumour suppressor, however its role in intestinal type 2 immunity is currently unclear. Here authors report that during parasitic infections, p53 triggers tuft cell Ca2+ influx and IL-25 release, and shows a regulatory role for p53 in intestinal type 2 immunity via transcriptiona...

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Autores principales: Chun-Yuan Chang, Jianming Wang, Yuhan Zhao, Juan Liu, Xue Yang, Xuetian Yue, Huaying Wang, Fan Zhou, Juan M. Inclan-Rico, John J. Ponessa, Ping Xie, Lanjing Zhang, Mark C. Siracusa, Zhaohui Feng, Wenwei Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f9bfbce6c11f42c2bf999c334a0f4939
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Sumario:P53 is a well-known tumour suppressor, however its role in intestinal type 2 immunity is currently unclear. Here authors report that during parasitic infections, p53 triggers tuft cell Ca2+ influx and IL-25 release, and shows a regulatory role for p53 in intestinal type 2 immunity via transcriptional regulation of the Lrmp gene.