Tumor suppressor p53 regulates intestinal type 2 immunity

P53 is a well-known tumour suppressor, however its role in intestinal type 2 immunity is currently unclear. Here authors report that during parasitic infections, p53 triggers tuft cell Ca2+ influx and IL-25 release, and shows a regulatory role for p53 in intestinal type 2 immunity via transcriptiona...

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Autores principales:	Chun-Yuan Chang, Jianming Wang, Yuhan Zhao, Juan Liu, Xue Yang, Xuetian Yue, Huaying Wang, Fan Zhou, Juan M. Inclan-Rico, John J. Ponessa, Ping Xie, Lanjing Zhang, Mark C. Siracusa, Zhaohui Feng, Wenwei Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f9bfbce6c11f42c2bf999c334a0f4939
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spelling	oai:doaj.org-article:f9bfbce6c11f42c2bf999c334a0f49392021-12-02T17:47:14ZTumor suppressor p53 regulates intestinal type 2 immunity10.1038/s41467-021-23587-x2041-1723https://doaj.org/article/f9bfbce6c11f42c2bf999c334a0f49392021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23587-xhttps://doaj.org/toc/2041-1723P53 is a well-known tumour suppressor, however its role in intestinal type 2 immunity is currently unclear. Here authors report that during parasitic infections, p53 triggers tuft cell Ca2+ influx and IL-25 release, and shows a regulatory role for p53 in intestinal type 2 immunity via transcriptional regulation of the Lrmp gene.Chun-Yuan ChangJianming WangYuhan ZhaoJuan LiuXue YangXuetian YueHuaying WangFan ZhouJuan M. Inclan-RicoJohn J. PonessaPing XieLanjing ZhangMark C. SiracusaZhaohui FengWenwei HuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chun-Yuan Chang Jianming Wang Yuhan Zhao Juan Liu Xue Yang Xuetian Yue Huaying Wang Fan Zhou Juan M. Inclan-Rico John J. Ponessa Ping Xie Lanjing Zhang Mark C. Siracusa Zhaohui Feng Wenwei Hu Tumor suppressor p53 regulates intestinal type 2 immunity
description	P53 is a well-known tumour suppressor, however its role in intestinal type 2 immunity is currently unclear. Here authors report that during parasitic infections, p53 triggers tuft cell Ca2+ influx and IL-25 release, and shows a regulatory role for p53 in intestinal type 2 immunity via transcriptional regulation of the Lrmp gene.
format	article
author	Chun-Yuan Chang Jianming Wang Yuhan Zhao Juan Liu Xue Yang Xuetian Yue Huaying Wang Fan Zhou Juan M. Inclan-Rico John J. Ponessa Ping Xie Lanjing Zhang Mark C. Siracusa Zhaohui Feng Wenwei Hu
author_facet	Chun-Yuan Chang Jianming Wang Yuhan Zhao Juan Liu Xue Yang Xuetian Yue Huaying Wang Fan Zhou Juan M. Inclan-Rico John J. Ponessa Ping Xie Lanjing Zhang Mark C. Siracusa Zhaohui Feng Wenwei Hu
author_sort	Chun-Yuan Chang
title	Tumor suppressor p53 regulates intestinal type 2 immunity
title_short	Tumor suppressor p53 regulates intestinal type 2 immunity
title_full	Tumor suppressor p53 regulates intestinal type 2 immunity
title_fullStr	Tumor suppressor p53 regulates intestinal type 2 immunity
title_full_unstemmed	Tumor suppressor p53 regulates intestinal type 2 immunity
title_sort	tumor suppressor p53 regulates intestinal type 2 immunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f9bfbce6c11f42c2bf999c334a0f4939
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Tumor suppressor p53 regulates intestinal type 2 immunity

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