Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function

Objective. The aim of the present study was to investigate the effect of hypoxia on the expression of genes encoding insulin-like growth factors (IGF1 and IGF2), their receptor (IGF1R), binding protein-4 (IGFBP4), and stanniocalcin 2 (STC2) in U87 glioma cells in relation to inhibition of endoplasmi...

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Autores principales:	Minchenko Dmytro O., Kharkova A. P., Halkin O. V., Karbovskyi L. L., Minchenko O. H.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	hypoxia igf1 igf1r igfbp4 stc2 mrna expression ire1 inhibition u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/f9c2745fb4784ee49eb113161b9136fd
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spelling	oai:doaj.org-article:f9c2745fb4784ee49eb113161b9136fd2021-12-02T15:29:49ZEffect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function1336-032910.1515/enr-2016-0008https://doaj.org/article/f9c2745fb4784ee49eb113161b9136fd2016-04-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0008https://doaj.org/toc/1336-0329Objective. The aim of the present study was to investigate the effect of hypoxia on the expression of genes encoding insulin-like growth factors (IGF1 and IGF2), their receptor (IGF1R), binding protein-4 (IGFBP4), and stanniocalcin 2 (STC2) in U87 glioma cells in relation to inhibition of endoplasmic reticulum stress signaling mediated by IRE1 (inositol requiring enzyme 1) for evaluation of their possible significance in the control of tumor growth.Minchenko Dmytro O.Kharkova A. P.Halkin O. V.Karbovskyi L. L.Minchenko O. H.Sciendoarticlehypoxiaigf1igf1igf1rigfbp4stc2mrna expressionire1 inhibitionu87 glioma cellsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 2, Pp 43-54 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypoxia igf1 igf1 igf1r igfbp4 stc2 mrna expression ire1 inhibition u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	hypoxia igf1 igf1 igf1r igfbp4 stc2 mrna expression ire1 inhibition u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665 Minchenko Dmytro O. Kharkova A. P. Halkin O. V. Karbovskyi L. L. Minchenko O. H. Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function
description	Objective. The aim of the present study was to investigate the effect of hypoxia on the expression of genes encoding insulin-like growth factors (IGF1 and IGF2), their receptor (IGF1R), binding protein-4 (IGFBP4), and stanniocalcin 2 (STC2) in U87 glioma cells in relation to inhibition of endoplasmic reticulum stress signaling mediated by IRE1 (inositol requiring enzyme 1) for evaluation of their possible significance in the control of tumor growth.
format	article
author	Minchenko Dmytro O. Kharkova A. P. Halkin O. V. Karbovskyi L. L. Minchenko O. H.
author_facet	Minchenko Dmytro O. Kharkova A. P. Halkin O. V. Karbovskyi L. L. Minchenko O. H.
author_sort	Minchenko Dmytro O.
title	Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function
title_short	Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function
title_full	Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function
title_fullStr	Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function
title_full_unstemmed	Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function
title_sort	effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in u87 glioma cells without ire1 function
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/f9c2745fb4784ee49eb113161b9136fd
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Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function

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