SPEN is required for Xist upregulation during initiation of X chromosome inactivation
SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.
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Nature Portfolio
2021
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oai:doaj.org-article:f9c3bed8f0db4091b5ce5fa62f64d44c2021-12-05T12:22:52ZSPEN is required for Xist upregulation during initiation of X chromosome inactivation10.1038/s41467-021-27294-52041-1723https://doaj.org/article/f9c3bed8f0db4091b5ce5fa62f64d44c2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27294-5https://doaj.org/toc/2041-1723SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.Teresa Robert-FinestraBeatrice F. TanHegias Mira-BontenbalErika TimmersCristina GontanSarra MerzoukBenedetto Daniele GiaimoFrançois DossinWilfred F. J. van IJckenJohn W. M. MartensTilman BorggrefeEdith HeardJoost GribnauNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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EN |
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Science Q |
spellingShingle |
Science Q Teresa Robert-Finestra Beatrice F. Tan Hegias Mira-Bontenbal Erika Timmers Cristina Gontan Sarra Merzouk Benedetto Daniele Giaimo François Dossin Wilfred F. J. van IJcken John W. M. Martens Tilman Borggrefe Edith Heard Joost Gribnau SPEN is required for Xist upregulation during initiation of X chromosome inactivation |
description |
SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix. |
format |
article |
author |
Teresa Robert-Finestra Beatrice F. Tan Hegias Mira-Bontenbal Erika Timmers Cristina Gontan Sarra Merzouk Benedetto Daniele Giaimo François Dossin Wilfred F. J. van IJcken John W. M. Martens Tilman Borggrefe Edith Heard Joost Gribnau |
author_facet |
Teresa Robert-Finestra Beatrice F. Tan Hegias Mira-Bontenbal Erika Timmers Cristina Gontan Sarra Merzouk Benedetto Daniele Giaimo François Dossin Wilfred F. J. van IJcken John W. M. Martens Tilman Borggrefe Edith Heard Joost Gribnau |
author_sort |
Teresa Robert-Finestra |
title |
SPEN is required for Xist upregulation during initiation of X chromosome inactivation |
title_short |
SPEN is required for Xist upregulation during initiation of X chromosome inactivation |
title_full |
SPEN is required for Xist upregulation during initiation of X chromosome inactivation |
title_fullStr |
SPEN is required for Xist upregulation during initiation of X chromosome inactivation |
title_full_unstemmed |
SPEN is required for Xist upregulation during initiation of X chromosome inactivation |
title_sort |
spen is required for xist upregulation during initiation of x chromosome inactivation |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/f9c3bed8f0db4091b5ce5fa62f64d44c |
work_keys_str_mv |
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1718372053187297280 |