SPEN is required for Xist upregulation during initiation of X chromosome inactivation

SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.

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Bibliographic Details
Main Authors:	Teresa Robert-Finestra, Beatrice F. Tan, Hegias Mira-Bontenbal, Erika Timmers, Cristina Gontan, Sarra Merzouk, Benedetto Daniele Giaimo, François Dossin, Wilfred F. J. van IJcken, John W. M. Martens, Tilman Borggrefe, Edith Heard, Joost Gribnau
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/f9c3bed8f0db4091b5ce5fa62f64d44c
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spelling	oai:doaj.org-article:f9c3bed8f0db4091b5ce5fa62f64d44c2021-12-05T12:22:52ZSPEN is required for Xist upregulation during initiation of X chromosome inactivation10.1038/s41467-021-27294-52041-1723https://doaj.org/article/f9c3bed8f0db4091b5ce5fa62f64d44c2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27294-5https://doaj.org/toc/2041-1723SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.Teresa Robert-FinestraBeatrice F. TanHegias Mira-BontenbalErika TimmersCristina GontanSarra MerzoukBenedetto Daniele GiaimoFrançois DossinWilfred F. J. van IJckenJohn W. M. MartensTilman BorggrefeEdith HeardJoost GribnauNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Teresa Robert-Finestra Beatrice F. Tan Hegias Mira-Bontenbal Erika Timmers Cristina Gontan Sarra Merzouk Benedetto Daniele Giaimo François Dossin Wilfred F. J. van IJcken John W. M. Martens Tilman Borggrefe Edith Heard Joost Gribnau SPEN is required for Xist upregulation during initiation of X chromosome inactivation
description	SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.
format	article
author	Teresa Robert-Finestra Beatrice F. Tan Hegias Mira-Bontenbal Erika Timmers Cristina Gontan Sarra Merzouk Benedetto Daniele Giaimo François Dossin Wilfred F. J. van IJcken John W. M. Martens Tilman Borggrefe Edith Heard Joost Gribnau
author_facet	Teresa Robert-Finestra Beatrice F. Tan Hegias Mira-Bontenbal Erika Timmers Cristina Gontan Sarra Merzouk Benedetto Daniele Giaimo François Dossin Wilfred F. J. van IJcken John W. M. Martens Tilman Borggrefe Edith Heard Joost Gribnau
author_sort	Teresa Robert-Finestra
title	SPEN is required for Xist upregulation during initiation of X chromosome inactivation
title_short	SPEN is required for Xist upregulation during initiation of X chromosome inactivation
title_full	SPEN is required for Xist upregulation during initiation of X chromosome inactivation
title_fullStr	SPEN is required for Xist upregulation during initiation of X chromosome inactivation
title_full_unstemmed	SPEN is required for Xist upregulation during initiation of X chromosome inactivation
title_sort	spen is required for xist upregulation during initiation of x chromosome inactivation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f9c3bed8f0db4091b5ce5fa62f64d44c
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SPEN is required for Xist upregulation during initiation of X chromosome inactivation

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