Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection

BackgroundThe preoperative systemic immune-inflammation index (SII) is correlated with prognosis in several malignancies. The aim of this study was to investigate the prognosis value of SII in patients with resected breast cancer.Materials and MethodsA total of 784 breast cancer patients who underwe...

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Autores principales:	Wen Li, Guangzhi Ma, Yunfu Deng, Wenjie Chen, Zhenkun Liu, Fang Chen, Qiang Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	breast cancer SII inflammation prognostic factor survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f9c4d63d933c42b3a0d028f3c6ae5f48
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spelling	oai:doaj.org-article:f9c4d63d933c42b3a0d028f3c6ae5f482021-12-01T21:30:01ZSystemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection2234-943X10.3389/fonc.2021.570208https://doaj.org/article/f9c4d63d933c42b3a0d028f3c6ae5f482021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.570208/fullhttps://doaj.org/toc/2234-943XBackgroundThe preoperative systemic immune-inflammation index (SII) is correlated with prognosis in several malignancies. The aim of this study was to investigate the prognosis value of SII in patients with resected breast cancer.Materials and MethodsA total of 784 breast cancer patients who underwent surgical resection were consecutively investigated. The optimal cutoff value of SII was evaluated using the receiver operating characteristic (ROC) curve. The collection of SII with clinicopathological characteristic and prognosis was further evaluated.ResultsThe optimal cutoff value for SII in the prediction of survival was 514 according to ROC curve analysis. A high SII was significantly correlated with younger age (P = 0.037), PR status (P < 0.001), and HER2 status (P = 0.035). Univariate analysis revealed that SII (P < 0.001), T-stage (P < 0.001), lymph node involvement post-surgery (P = 0.024), and histological grade (P < 0.001) were significantly related to DFS, and SII (P < 0.001), T-stage (P = 0.003), lymph node involvement post-surgery (P = 0.006), and histological grade (P < 0.001) were significantly associated with OS. In multivariate analysis, a high SII was an independent worse prognostic factor for DFS (HR, 4.530; 95% CI, 3.279-6.258; P < 0.001) and OS (HR, 3.825; 95% CI, 2.594-5.640; P < 0.001) in all the enrolled patients. Furthermore, subgroup analysis of molecular subtype revealed that SII was significantly associated with prognosis in all subtypes.ConclusionPreoperative SII is a simple and useful prognostic factor for predicting long-term outcomes for breast cancer patients undergoing surgery.Wen LiGuangzhi MaYunfu DengYunfu DengWenjie ChenWenjie ChenZhenkun LiuFang ChenQiang WuFrontiers Media S.A.articlebreast cancerSIIinflammationprognostic factorsurvivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer SII inflammation prognostic factor survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer SII inflammation prognostic factor survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wen Li Guangzhi Ma Yunfu Deng Yunfu Deng Wenjie Chen Wenjie Chen Zhenkun Liu Fang Chen Qiang Wu Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection
description	BackgroundThe preoperative systemic immune-inflammation index (SII) is correlated with prognosis in several malignancies. The aim of this study was to investigate the prognosis value of SII in patients with resected breast cancer.Materials and MethodsA total of 784 breast cancer patients who underwent surgical resection were consecutively investigated. The optimal cutoff value of SII was evaluated using the receiver operating characteristic (ROC) curve. The collection of SII with clinicopathological characteristic and prognosis was further evaluated.ResultsThe optimal cutoff value for SII in the prediction of survival was 514 according to ROC curve analysis. A high SII was significantly correlated with younger age (P = 0.037), PR status (P < 0.001), and HER2 status (P = 0.035). Univariate analysis revealed that SII (P < 0.001), T-stage (P < 0.001), lymph node involvement post-surgery (P = 0.024), and histological grade (P < 0.001) were significantly related to DFS, and SII (P < 0.001), T-stage (P = 0.003), lymph node involvement post-surgery (P = 0.006), and histological grade (P < 0.001) were significantly associated with OS. In multivariate analysis, a high SII was an independent worse prognostic factor for DFS (HR, 4.530; 95% CI, 3.279-6.258; P < 0.001) and OS (HR, 3.825; 95% CI, 2.594-5.640; P < 0.001) in all the enrolled patients. Furthermore, subgroup analysis of molecular subtype revealed that SII was significantly associated with prognosis in all subtypes.ConclusionPreoperative SII is a simple and useful prognostic factor for predicting long-term outcomes for breast cancer patients undergoing surgery.
format	article
author	Wen Li Guangzhi Ma Yunfu Deng Yunfu Deng Wenjie Chen Wenjie Chen Zhenkun Liu Fang Chen Qiang Wu
author_facet	Wen Li Guangzhi Ma Yunfu Deng Yunfu Deng Wenjie Chen Wenjie Chen Zhenkun Liu Fang Chen Qiang Wu
author_sort	Wen Li
title	Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection
title_short	Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection
title_full	Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection
title_fullStr	Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection
title_full_unstemmed	Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection
title_sort	systemic immune-inflammation index is a prognostic factor for breast cancer patients after curative resection
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f9c4d63d933c42b3a0d028f3c6ae5f48
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Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection

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