A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans

XACT is a primate-specific TE-derived lncRNA that coats active X chromosomes in pluripotent cells and may contribute to species-specific regulation of X chromosome inactivation. Here, the authors investigate TEs associated with the XACT locus and identify a critical enhancer for its regulation, whic...

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Autores principales:	Miguel Casanova, Madeleine Moscatelli, Louis Édouard Chauvière, Christophe Huret, Julia Samson, Tharvesh Moideen Liyakat Ali, Olga Rosspopoff, Claire Rougeulle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f9c5f63441214330bad8768b8203536f
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spelling	oai:doaj.org-article:f9c5f63441214330bad8768b8203536f2021-12-02T16:57:42ZA primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans10.1038/s41467-019-13551-12041-1723https://doaj.org/article/f9c5f63441214330bad8768b8203536f2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13551-1https://doaj.org/toc/2041-1723XACT is a primate-specific TE-derived lncRNA that coats active X chromosomes in pluripotent cells and may contribute to species-specific regulation of X chromosome inactivation. Here, the authors investigate TEs associated with the XACT locus and identify a critical enhancer for its regulation, which evolved from an ancestral group of mammalian endogenous retroviruses, prior to the emergence of XACT.Miguel CasanovaMadeleine MoscatelliLouis Édouard ChauvièreChristophe HuretJulia SamsonTharvesh Moideen Liyakat AliOlga RosspopoffClaire RougeulleNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miguel Casanova Madeleine Moscatelli Louis Édouard Chauvière Christophe Huret Julia Samson Tharvesh Moideen Liyakat Ali Olga Rosspopoff Claire Rougeulle A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans
description	XACT is a primate-specific TE-derived lncRNA that coats active X chromosomes in pluripotent cells and may contribute to species-specific regulation of X chromosome inactivation. Here, the authors investigate TEs associated with the XACT locus and identify a critical enhancer for its regulation, which evolved from an ancestral group of mammalian endogenous retroviruses, prior to the emergence of XACT.
format	article
author	Miguel Casanova Madeleine Moscatelli Louis Édouard Chauvière Christophe Huret Julia Samson Tharvesh Moideen Liyakat Ali Olga Rosspopoff Claire Rougeulle
author_facet	Miguel Casanova Madeleine Moscatelli Louis Édouard Chauvière Christophe Huret Julia Samson Tharvesh Moideen Liyakat Ali Olga Rosspopoff Claire Rougeulle
author_sort	Miguel Casanova
title	A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans
title_short	A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans
title_full	A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans
title_fullStr	A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans
title_full_unstemmed	A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans
title_sort	primate-specific retroviral enhancer wires the xact lncrna into the core pluripotency network in humans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f9c5f63441214330bad8768b8203536f
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A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans

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