Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo
Cancer treatment is challenging due to late-stage diagnosis, drug resistance and systemic toxicity of chemotherapeutic agents. The formulation of the drug into nanoparticles (NPs) can enhance the treatment efficacy and effectiveness. Therefore, a new cationic niosomal formulation, which contains Twe...
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De Gruyter
2021
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oai:doaj.org-article:f9d086461d14440484f50118604455392021-12-05T14:10:58ZSmart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo2191-909710.1515/ntrev-2021-0119https://doaj.org/article/f9d086461d14440484f50118604455392021-11-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0119https://doaj.org/toc/2191-9097Cancer treatment is challenging due to late-stage diagnosis, drug resistance and systemic toxicity of chemotherapeutic agents. The formulation of the drug into nanoparticles (NPs) can enhance the treatment efficacy and effectiveness. Therefore, a new cationic niosomal formulation, which contains Tween 80, Tween 60, cholesterol and lysine amino acid as a platform model to enhance transfection efficacy and reach more acceptable stability, and curcumin (Cur) as a biological anti-cancer drug, are introduced. Here, the authors focused on the design and synthesis of novel lysine-mediated niosomal NPs for the effectual and controlled release of the antitumor agent, Cur, and turned to optimize niosome formulations, concerning the volume of cholesterol and surfactant to implement these anticancer agents, simultaneously. The characterization of NPs s was carried out and the results showed the successful synthesis of Cur-entrapped niosomal NPs with high efficacy, sufficient positive charges and a favorable size (95/33 nm). The in vitro studies have been performed to investigate the cytotoxicity, cellular uptake and apoptosis of normal and cancer cells treated by black niosome, free Cur and niosom-loaded Cur. The results showed that implementing agents by niosome caused enhanced cytotoxicity, uptake and anticancer activity in cancer cells in comparison with normal cells. Furthermore, the effect of this nanodrug was surveyed on the 4T1 xenografted Balb/C mouse tumor model. Cur delivery to cancer models caused a higher tumor inhibition rate than in other groups.Abtahi Najmeh AlsadatNaghib Seyed MortezaHaghiralsadat FatemehReza Javad ZavarHakimian FatemehYazdian FatemehTofighi DavoodDe Gruyterarticlenanoparticlesnoisomelysinetweencurcumincancer treatmentTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 1895-1911 (2021) |
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EN |
| topic |
nanoparticles noisome lysine tween curcumin cancer treatment Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 |
| spellingShingle |
nanoparticles noisome lysine tween curcumin cancer treatment Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Abtahi Najmeh Alsadat Naghib Seyed Morteza Haghiralsadat Fatemeh Reza Javad Zavar Hakimian Fatemeh Yazdian Fatemeh Tofighi Davood Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo |
| description |
Cancer treatment is challenging due to late-stage diagnosis, drug resistance and systemic toxicity of chemotherapeutic agents. The formulation of the drug into nanoparticles (NPs) can enhance the treatment efficacy and effectiveness. Therefore, a new cationic niosomal formulation, which contains Tween 80, Tween 60, cholesterol and lysine amino acid as a platform model to enhance transfection efficacy and reach more acceptable stability, and curcumin (Cur) as a biological anti-cancer drug, are introduced. Here, the authors focused on the design and synthesis of novel lysine-mediated niosomal NPs for the effectual and controlled release of the antitumor agent, Cur, and turned to optimize niosome formulations, concerning the volume of cholesterol and surfactant to implement these anticancer agents, simultaneously. The characterization of NPs s was carried out and the results showed the successful synthesis of Cur-entrapped niosomal NPs with high efficacy, sufficient positive charges and a favorable size (95/33 nm). The in vitro studies have been performed to investigate the cytotoxicity, cellular uptake and apoptosis of normal and cancer cells treated by black niosome, free Cur and niosom-loaded Cur. The results showed that implementing agents by niosome caused enhanced cytotoxicity, uptake and anticancer activity in cancer cells in comparison with normal cells. Furthermore, the effect of this nanodrug was surveyed on the 4T1 xenografted Balb/C mouse tumor model. Cur delivery to cancer models caused a higher tumor inhibition rate than in other groups. |
| format |
article |
| author |
Abtahi Najmeh Alsadat Naghib Seyed Morteza Haghiralsadat Fatemeh Reza Javad Zavar Hakimian Fatemeh Yazdian Fatemeh Tofighi Davood |
| author_facet |
Abtahi Najmeh Alsadat Naghib Seyed Morteza Haghiralsadat Fatemeh Reza Javad Zavar Hakimian Fatemeh Yazdian Fatemeh Tofighi Davood |
| author_sort |
Abtahi Najmeh Alsadat |
| title |
Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo |
| title_short |
Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo |
| title_full |
Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo |
| title_fullStr |
Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo |
| title_full_unstemmed |
Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo |
| title_sort |
smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo |
| publisher |
De Gruyter |
| publishDate |
2021 |
| url |
https://doaj.org/article/f9d086461d14440484f5011860445539 |
| work_keys_str_mv |
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