Targeting Splicing Factor SRSF6 for Cancer Therapy

Aberrant alternative splicing of pre-mRNA is an emerging cancer hallmark. Many cancer-associated genes undergo alternative splicing to produce multiple isoforms with diverse or even antagonistic functions. Oncogenic isoforms are often up-regulated, whereas tumor suppressive isoforms are down-regulat...

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Autores principales:	Wenting She, Jun Shao, Rong Jia
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SRSF6 oncogene alternative splicing cancer therapy overexpression Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f9d173cd2a4642768048b4c909c3c95d
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spelling	oai:doaj.org-article:f9d173cd2a4642768048b4c909c3c95d2021-12-01T17:02:03ZTargeting Splicing Factor SRSF6 for Cancer Therapy2296-634X10.3389/fcell.2021.780023https://doaj.org/article/f9d173cd2a4642768048b4c909c3c95d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.780023/fullhttps://doaj.org/toc/2296-634XAberrant alternative splicing of pre-mRNA is an emerging cancer hallmark. Many cancer-associated genes undergo alternative splicing to produce multiple isoforms with diverse or even antagonistic functions. Oncogenic isoforms are often up-regulated, whereas tumor suppressive isoforms are down-regulated during tumorigenesis. Serine/arginine-rich splicing factor 6 (SRSF6) is an important splicing factor that regulates the alternative splicing of hundreds of target genes, including many cancer-associated genes. The potential roles of SRSF6 in cancers have attracted increasing attentions in the past decade. Accumulated pieces of evidence have shown that SRSF6 is a potential oncogenic gene that promotes oncogenic splicing when overexpressed. Targeting SRSF6 may suppress tumorigenesis. In this review, we describe the gene, mRNA, and protein structure of SRSF6; summarize the current understanding of the expression, functions, and regulatory mechanisms of SRSF6 during tumorigenesis; and discuss the potential application of targeting SRSF6 in cancer treatment.Wenting SheWenting SheJun ShaoRong JiaFrontiers Media S.A.articleSRSF6oncogenealternative splicingcancer therapyoverexpressionBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SRSF6 oncogene alternative splicing cancer therapy overexpression Biology (General) QH301-705.5
spellingShingle	SRSF6 oncogene alternative splicing cancer therapy overexpression Biology (General) QH301-705.5 Wenting She Wenting She Jun Shao Rong Jia Targeting Splicing Factor SRSF6 for Cancer Therapy
description	Aberrant alternative splicing of pre-mRNA is an emerging cancer hallmark. Many cancer-associated genes undergo alternative splicing to produce multiple isoforms with diverse or even antagonistic functions. Oncogenic isoforms are often up-regulated, whereas tumor suppressive isoforms are down-regulated during tumorigenesis. Serine/arginine-rich splicing factor 6 (SRSF6) is an important splicing factor that regulates the alternative splicing of hundreds of target genes, including many cancer-associated genes. The potential roles of SRSF6 in cancers have attracted increasing attentions in the past decade. Accumulated pieces of evidence have shown that SRSF6 is a potential oncogenic gene that promotes oncogenic splicing when overexpressed. Targeting SRSF6 may suppress tumorigenesis. In this review, we describe the gene, mRNA, and protein structure of SRSF6; summarize the current understanding of the expression, functions, and regulatory mechanisms of SRSF6 during tumorigenesis; and discuss the potential application of targeting SRSF6 in cancer treatment.
format	article
author	Wenting She Wenting She Jun Shao Rong Jia
author_facet	Wenting She Wenting She Jun Shao Rong Jia
author_sort	Wenting She
title	Targeting Splicing Factor SRSF6 for Cancer Therapy
title_short	Targeting Splicing Factor SRSF6 for Cancer Therapy
title_full	Targeting Splicing Factor SRSF6 for Cancer Therapy
title_fullStr	Targeting Splicing Factor SRSF6 for Cancer Therapy
title_full_unstemmed	Targeting Splicing Factor SRSF6 for Cancer Therapy
title_sort	targeting splicing factor srsf6 for cancer therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f9d173cd2a4642768048b4c909c3c95d
work_keys_str_mv	AT wentingshe targetingsplicingfactorsrsf6forcancertherapy AT wentingshe targetingsplicingfactorsrsf6forcancertherapy AT junshao targetingsplicingfactorsrsf6forcancertherapy AT rongjia targetingsplicingfactorsrsf6forcancertherapy
_version_	1718404790408445952

Targeting Splicing Factor SRSF6 for Cancer Therapy

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