Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.

Cancer is often associated with cachexia, cardiovascular symptoms and autonomic dysregulation. We tested whether extracardiac cancer directly affects the innervation of left ventricular myocardium. Mice injected with Lewis lung carcinoma cells (tumor group, TG) or PBS (control group, CG) were analyz...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christian Mühlfeld, Suman Kumar Das, Frank R Heinzel, Albrecht Schmidt, Heiner Post, Silvia Schauer, Tamara Papadakis, Wolfgang Kummer, Gerald Hoefler
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9d2dd92aea9406e8427fa1f3dd5d3c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f9d2dd92aea9406e8427fa1f3dd5d3c9
record_format	dspace
spelling	oai:doaj.org-article:f9d2dd92aea9406e8427fa1f3dd5d3c92021-11-18T06:53:10ZCancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.1932-620310.1371/journal.pone.0020424https://doaj.org/article/f9d2dd92aea9406e8427fa1f3dd5d3c92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21637823/?tool=EBIhttps://doaj.org/toc/1932-6203Cancer is often associated with cachexia, cardiovascular symptoms and autonomic dysregulation. We tested whether extracardiac cancer directly affects the innervation of left ventricular myocardium. Mice injected with Lewis lung carcinoma cells (tumor group, TG) or PBS (control group, CG) were analyzed after 21 days. Cardiac function (echocardiography), serum levels of TNF-α and Il-6 (ELISA), structural alterations of cardiomyocytes and their innervation (design-based stereology) and levels of innervation-related mRNA (quantitative RT-PCR) were analysed. The groups did not differ in various functional parameters. Serum levels of TNF-α and Il-6 were elevated in TG. The total length of axons in the left ventricle was reduced. The number of dense core vesicles per axon profile was reduced. Decreased myofibrillar volume, increased sarcoplasmic volume and increased volume of lipid droplets were indicative of metabolic alterations of TG cardiomyocytes. In the heart, the mRNA level of nerve growth factor was reduced whereas that of β1-adrenergic receptor was unchanged in TG. In the stellate ganglion of TG, mRNA levels of nerve growth factor and neuropeptide Y were decreased and that of tyrosine hydroxylase was increased. In summary, cancer induces a systemic pro-inflammatory state, a significant reduction in myocardial innervation and a catabolic phenotype of cardiomyocytes in the mouse. Reduced expression of nerve growth factor may account for the reduced myocardial innervation.Christian MühlfeldSuman Kumar DasFrank R HeinzelAlbrecht SchmidtHeiner PostSilvia SchauerTamara PapadakisWolfgang KummerGerald HoeflerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20424 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian Mühlfeld Suman Kumar Das Frank R Heinzel Albrecht Schmidt Heiner Post Silvia Schauer Tamara Papadakis Wolfgang Kummer Gerald Hoefler Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.
description	Cancer is often associated with cachexia, cardiovascular symptoms and autonomic dysregulation. We tested whether extracardiac cancer directly affects the innervation of left ventricular myocardium. Mice injected with Lewis lung carcinoma cells (tumor group, TG) or PBS (control group, CG) were analyzed after 21 days. Cardiac function (echocardiography), serum levels of TNF-α and Il-6 (ELISA), structural alterations of cardiomyocytes and their innervation (design-based stereology) and levels of innervation-related mRNA (quantitative RT-PCR) were analysed. The groups did not differ in various functional parameters. Serum levels of TNF-α and Il-6 were elevated in TG. The total length of axons in the left ventricle was reduced. The number of dense core vesicles per axon profile was reduced. Decreased myofibrillar volume, increased sarcoplasmic volume and increased volume of lipid droplets were indicative of metabolic alterations of TG cardiomyocytes. In the heart, the mRNA level of nerve growth factor was reduced whereas that of β1-adrenergic receptor was unchanged in TG. In the stellate ganglion of TG, mRNA levels of nerve growth factor and neuropeptide Y were decreased and that of tyrosine hydroxylase was increased. In summary, cancer induces a systemic pro-inflammatory state, a significant reduction in myocardial innervation and a catabolic phenotype of cardiomyocytes in the mouse. Reduced expression of nerve growth factor may account for the reduced myocardial innervation.
format	article
author	Christian Mühlfeld Suman Kumar Das Frank R Heinzel Albrecht Schmidt Heiner Post Silvia Schauer Tamara Papadakis Wolfgang Kummer Gerald Hoefler
author_facet	Christian Mühlfeld Suman Kumar Das Frank R Heinzel Albrecht Schmidt Heiner Post Silvia Schauer Tamara Papadakis Wolfgang Kummer Gerald Hoefler
author_sort	Christian Mühlfeld
title	Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.
title_short	Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.
title_full	Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.
title_fullStr	Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.
title_full_unstemmed	Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.
title_sort	cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/f9d2dd92aea9406e8427fa1f3dd5d3c9
work_keys_str_mv	AT christianmuhlfeld cancerinducescardiomyocyteremodelingandhypoinnervationintheleftventricleofthemouseheart AT sumankumardas cancerinducescardiomyocyteremodelingandhypoinnervationintheleftventricleofthemouseheart AT frankrheinzel cancerinducescardiomyocyteremodelingandhypoinnervationintheleftventricleofthemouseheart AT albrechtschmidt cancerinducescardiomyocyteremodelingandhypoinnervationintheleftventricleofthemouseheart AT heinerpost cancerinducescardiomyocyteremodelingandhypoinnervationintheleftventricleofthemouseheart AT silviaschauer cancerinducescardiomyocyteremodelingandhypoinnervationintheleftventricleofthemouseheart AT tamarapapadakis cancerinducescardiomyocyteremodelingandhypoinnervationintheleftventricleofthemouseheart AT wolfgangkummer cancerinducescardiomyocyteremodelingandhypoinnervationintheleftventricleofthemouseheart AT geraldhoefler cancerinducescardiomyocyteremodelingandhypoinnervationintheleftventricleofthemouseheart
_version_	1718424267769511936

Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.

Ejemplares similares