Electroneuromyography for early diagnosis of diabetic distal polyneuropathy

BACKGROUND: Diabetic distal polyneuropathy (DDPN) is a predictor of diabetic foot syndrome development, ulcer formation and lower limb amputation. An early DDPN diagnosis is therefore relevant. AIM: To investigate the effectiveness and suitability of electroneuromyography (ENMG) for early DDPN diag...

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Autores principales:	Elena S. Mazurenko, Lyudmila A. Ruyatkina, Igor A. Pakhomov, Elena V. Chesheva, Larisa O. Gavrilova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2019
Materias:	diabetes mellitus diabetic distal polyneuropathy electroneuromyography diagnosis Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/f9d71bd9da154f2fb6520711d8b3e0c7
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spelling	oai:doaj.org-article:f9d71bd9da154f2fb6520711d8b3e0c72021-11-14T09:00:22ZElectroneuromyography for early diagnosis of diabetic distal polyneuropathy2072-03512072-037810.14341/DM9830https://doaj.org/article/f9d71bd9da154f2fb6520711d8b3e0c72019-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/9830https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378BACKGROUND: Diabetic distal polyneuropathy (DDPN) is a predictor of diabetic foot syndrome development, ulcer formation and lower limb amputation. An early DDPN diagnosis is therefore relevant. AIM: To investigate the effectiveness and suitability of electroneuromyography (ENMG) for early DDPN diagnosis. MATERIALS AND METHODS: This study was performed in the Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya. L. Tsivyan. A total of 80 participants were examined, including 30 DM2 patients, 30 patents without carbohydrate metabolism disorders, and 20 healthy volunteers aged 20–30 years. None of the participants showed clinical signs of distal polyneuropathy (DPN). All participants underwent evaluation of neuropathy symptoms by the Neuropathy Symptom Score scale, neurological assessment using on the scale of Neuropathic Dysfunctional Score and stimulating ENMG. RESULTS: ENMG revealed the presence of neuropathy in 86.7% of DM2 patients. Moreover, among DM2 patients, 12 (40%) presented sensory DDPN, 13 (43.3%) presented sensorimotor neuropathy and 1 (3.3%) presented motor DDPN. The medial and lateral plantar nerves were the most commonly affected (p = 0.018 and p = 0.002, respectively). Among the 30 control individuals, 9 (30%) showed signs of DPN in combination with radiculopathy. ENMG - indicators of DDPN: latency and amplitude and speed for 3 sensory (n. Plantaris lateralis, n. Plantaris medialis, n. Suralis) and 2 motor nerves (n. Peroneus, n. Tibialis) were significantly worse in individuals with DM2 than in the control group, both for those with and without radiculopathy. Among participants with DM2, those sensorimotor DDPN tended to have a longer diabetes duration (p = 0.503), higher levels of HbA1c (p = 0.077) and higher BMI (p = 0.050) than those with sensory neuropathy, although the differences were not significant. CONCLUSION: This study confirms the effectiveness and suitability of ENMG for the early diagnosis of DDPN. Moreover, the optimal ENMG indices necessary for this diagnosis were identified.Elena S. MazurenkoLyudmila A. RuyatkinaIgor A. PakhomovElena V. CheshevaLarisa O. GavrilovaEndocrinology Research Centrearticlediabetes mellitusdiabetic distal polyneuropathyelectroneuromyographydiagnosisNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 2, Pp 141-150 (2019)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus diabetic distal polyneuropathy electroneuromyography diagnosis Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus diabetic distal polyneuropathy electroneuromyography diagnosis Nutritional diseases. Deficiency diseases RC620-627 Elena S. Mazurenko Lyudmila A. Ruyatkina Igor A. Pakhomov Elena V. Chesheva Larisa O. Gavrilova Electroneuromyography for early diagnosis of diabetic distal polyneuropathy
description	BACKGROUND: Diabetic distal polyneuropathy (DDPN) is a predictor of diabetic foot syndrome development, ulcer formation and lower limb amputation. An early DDPN diagnosis is therefore relevant. AIM: To investigate the effectiveness and suitability of electroneuromyography (ENMG) for early DDPN diagnosis. MATERIALS AND METHODS: This study was performed in the Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya. L. Tsivyan. A total of 80 participants were examined, including 30 DM2 patients, 30 patents without carbohydrate metabolism disorders, and 20 healthy volunteers aged 20–30 years. None of the participants showed clinical signs of distal polyneuropathy (DPN). All participants underwent evaluation of neuropathy symptoms by the Neuropathy Symptom Score scale, neurological assessment using on the scale of Neuropathic Dysfunctional Score and stimulating ENMG. RESULTS: ENMG revealed the presence of neuropathy in 86.7% of DM2 patients. Moreover, among DM2 patients, 12 (40%) presented sensory DDPN, 13 (43.3%) presented sensorimotor neuropathy and 1 (3.3%) presented motor DDPN. The medial and lateral plantar nerves were the most commonly affected (p = 0.018 and p = 0.002, respectively). Among the 30 control individuals, 9 (30%) showed signs of DPN in combination with radiculopathy. ENMG - indicators of DDPN: latency and amplitude and speed for 3 sensory (n. Plantaris lateralis, n. Plantaris medialis, n. Suralis) and 2 motor nerves (n. Peroneus, n. Tibialis) were significantly worse in individuals with DM2 than in the control group, both for those with and without radiculopathy. Among participants with DM2, those sensorimotor DDPN tended to have a longer diabetes duration (p = 0.503), higher levels of HbA1c (p = 0.077) and higher BMI (p = 0.050) than those with sensory neuropathy, although the differences were not significant. CONCLUSION: This study confirms the effectiveness and suitability of ENMG for the early diagnosis of DDPN. Moreover, the optimal ENMG indices necessary for this diagnosis were identified.
format	article
author	Elena S. Mazurenko Lyudmila A. Ruyatkina Igor A. Pakhomov Elena V. Chesheva Larisa O. Gavrilova
author_facet	Elena S. Mazurenko Lyudmila A. Ruyatkina Igor A. Pakhomov Elena V. Chesheva Larisa O. Gavrilova
author_sort	Elena S. Mazurenko
title	Electroneuromyography for early diagnosis of diabetic distal polyneuropathy
title_short	Electroneuromyography for early diagnosis of diabetic distal polyneuropathy
title_full	Electroneuromyography for early diagnosis of diabetic distal polyneuropathy
title_fullStr	Electroneuromyography for early diagnosis of diabetic distal polyneuropathy
title_full_unstemmed	Electroneuromyography for early diagnosis of diabetic distal polyneuropathy
title_sort	electroneuromyography for early diagnosis of diabetic distal polyneuropathy
publisher	Endocrinology Research Centre
publishDate	2019
url	https://doaj.org/article/f9d71bd9da154f2fb6520711d8b3e0c7
work_keys_str_mv	AT elenasmazurenko electroneuromyographyforearlydiagnosisofdiabeticdistalpolyneuropathy AT lyudmilaaruyatkina electroneuromyographyforearlydiagnosisofdiabeticdistalpolyneuropathy AT igorapakhomov electroneuromyographyforearlydiagnosisofdiabeticdistalpolyneuropathy AT elenavchesheva electroneuromyographyforearlydiagnosisofdiabeticdistalpolyneuropathy AT larisaogavrilova electroneuromyographyforearlydiagnosisofdiabeticdistalpolyneuropathy
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Electroneuromyography for early diagnosis of diabetic distal polyneuropathy

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