The limits of individual identification from sample allele frequencies: theory and statistical analysis.

It was shown recently using experimental data that it is possible under certain conditions to determine whether a person with known genotypes at a number of markers was part of a sample from which only allele frequencies are known. Using population genetic and statistical theory, we show that the po...

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Autores principales:	Peter M Visscher, William G Hill
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/f9da9c5668d146f490cf96c23cd785b5
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spelling	oai:doaj.org-article:f9da9c5668d146f490cf96c23cd785b52021-11-25T05:53:05ZThe limits of individual identification from sample allele frequencies: theory and statistical analysis.1553-73901553-740410.1371/journal.pgen.1000628https://doaj.org/article/f9da9c5668d146f490cf96c23cd785b52009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19798439/pdf/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404It was shown recently using experimental data that it is possible under certain conditions to determine whether a person with known genotypes at a number of markers was part of a sample from which only allele frequencies are known. Using population genetic and statistical theory, we show that the power of such identification is, approximately, proportional to the number of independent SNPs divided by the size of the sample from which the allele frequencies are available. We quantify the limits of identification and propose likelihood and regression analysis methods for the analysis of data. We show that these methods have similar statistical properties and have more desirable properties, in terms of type-I error rate and statistical power, than test statistics suggested in the literature.Peter M VisscherWilliam G HillPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 5, Iss 10, p e1000628 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Peter M Visscher William G Hill The limits of individual identification from sample allele frequencies: theory and statistical analysis.
description	It was shown recently using experimental data that it is possible under certain conditions to determine whether a person with known genotypes at a number of markers was part of a sample from which only allele frequencies are known. Using population genetic and statistical theory, we show that the power of such identification is, approximately, proportional to the number of independent SNPs divided by the size of the sample from which the allele frequencies are available. We quantify the limits of identification and propose likelihood and regression analysis methods for the analysis of data. We show that these methods have similar statistical properties and have more desirable properties, in terms of type-I error rate and statistical power, than test statistics suggested in the literature.
format	article
author	Peter M Visscher William G Hill
author_facet	Peter M Visscher William G Hill
author_sort	Peter M Visscher
title	The limits of individual identification from sample allele frequencies: theory and statistical analysis.
title_short	The limits of individual identification from sample allele frequencies: theory and statistical analysis.
title_full	The limits of individual identification from sample allele frequencies: theory and statistical analysis.
title_fullStr	The limits of individual identification from sample allele frequencies: theory and statistical analysis.
title_full_unstemmed	The limits of individual identification from sample allele frequencies: theory and statistical analysis.
title_sort	limits of individual identification from sample allele frequencies: theory and statistical analysis.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/f9da9c5668d146f490cf96c23cd785b5
work_keys_str_mv	AT petermvisscher thelimitsofindividualidentificationfromsampleallelefrequenciestheoryandstatisticalanalysis AT williamghill thelimitsofindividualidentificationfromsampleallelefrequenciestheoryandstatisticalanalysis AT petermvisscher limitsofindividualidentificationfromsampleallelefrequenciestheoryandstatisticalanalysis AT williamghill limitsofindividualidentificationfromsampleallelefrequenciestheoryandstatisticalanalysis
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The limits of individual identification from sample allele frequencies: theory and statistical analysis.

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