Auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations

Abstract Our understanding of the neural correlates of auditory-verbal-hallucinations (AVH) has substantially increased during the last few years, but is far from sufficient. One current hypothesis, the interhemispheric miscommunication theory, is based on findings from fMRI, DTI and EEG, but there...

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Autores principales:	Saskia Steinmann, Gregor Leicht, Christina Andreou, Nenad Polomac, Christoph Mulert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9dc2a1141ab4078bd72514f4e89ed9a
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spelling	oai:doaj.org-article:f9dc2a1141ab4078bd72514f4e89ed9a2021-12-02T12:30:28ZAuditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations10.1038/s41598-017-09253-72045-2322https://doaj.org/article/f9dc2a1141ab4078bd72514f4e89ed9a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09253-7https://doaj.org/toc/2045-2322Abstract Our understanding of the neural correlates of auditory-verbal-hallucinations (AVH) has substantially increased during the last few years, but is far from sufficient. One current hypothesis, the interhemispheric miscommunication theory, is based on findings from fMRI, DTI and EEG, but there is only limited evidence so far concerning underlying functional coupling mechanisms. Here we report a 64-channel EEG study using lagged phase synchronization analysis and eLORETA source estimation to examine the functional connectivity between bilateral auditory cortices in the gamma-band in 26 schizophrenia patients (13 with and 13 without AVH) and 26 matched healthy controls (HC) while performing a dichotic listening task. We found a significantly reduced right-ear-advantage (REA) in AVH but not in non-AVH patients compared to HC. The major finding was significantly stronger gamma-band connectivity between bilateral auditory cortices during conscious perception of left (versus right) ear syllables in patients with AVH compared to HC and patients without AVH. A significant positive correlation was found between this connectivity alteration and the AVH symptom score in schizophrenia patients. These findings provide further support for the interhemispheric miscommunication hypothesis of AVH pathophysiology by indicating that aberrant gamma-band coupling between auditory cortices is related to the emergence of AVH in schizophrenia.Saskia SteinmannGregor LeichtChristina AndreouNenad PolomacChristoph MulertNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saskia Steinmann Gregor Leicht Christina Andreou Nenad Polomac Christoph Mulert Auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations
description	Abstract Our understanding of the neural correlates of auditory-verbal-hallucinations (AVH) has substantially increased during the last few years, but is far from sufficient. One current hypothesis, the interhemispheric miscommunication theory, is based on findings from fMRI, DTI and EEG, but there is only limited evidence so far concerning underlying functional coupling mechanisms. Here we report a 64-channel EEG study using lagged phase synchronization analysis and eLORETA source estimation to examine the functional connectivity between bilateral auditory cortices in the gamma-band in 26 schizophrenia patients (13 with and 13 without AVH) and 26 matched healthy controls (HC) while performing a dichotic listening task. We found a significantly reduced right-ear-advantage (REA) in AVH but not in non-AVH patients compared to HC. The major finding was significantly stronger gamma-band connectivity between bilateral auditory cortices during conscious perception of left (versus right) ear syllables in patients with AVH compared to HC and patients without AVH. A significant positive correlation was found between this connectivity alteration and the AVH symptom score in schizophrenia patients. These findings provide further support for the interhemispheric miscommunication hypothesis of AVH pathophysiology by indicating that aberrant gamma-band coupling between auditory cortices is related to the emergence of AVH in schizophrenia.
format	article
author	Saskia Steinmann Gregor Leicht Christina Andreou Nenad Polomac Christoph Mulert
author_facet	Saskia Steinmann Gregor Leicht Christina Andreou Nenad Polomac Christoph Mulert
author_sort	Saskia Steinmann
title	Auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations
title_short	Auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations
title_full	Auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations
title_fullStr	Auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations
title_full_unstemmed	Auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations
title_sort	auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f9dc2a1141ab4078bd72514f4e89ed9a
work_keys_str_mv	AT saskiasteinmann auditoryverbalhallucinationsrelatedtoalteredlongrangesynchronyofgammabandoscillations AT gregorleicht auditoryverbalhallucinationsrelatedtoalteredlongrangesynchronyofgammabandoscillations AT christinaandreou auditoryverbalhallucinationsrelatedtoalteredlongrangesynchronyofgammabandoscillations AT nenadpolomac auditoryverbalhallucinationsrelatedtoalteredlongrangesynchronyofgammabandoscillations AT christophmulert auditoryverbalhallucinationsrelatedtoalteredlongrangesynchronyofgammabandoscillations
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Auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations

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