Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals

The detailed morphometry alterations of the human hippocampal formation (HF) for blind individuals are still understudied. 50 subjects were recruited from Yantai Affiliated Hospital of Binzhou Medical University, including 16 congenital blindness, 14 late blindness, and 20 sighted controls. Volume a...

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Autores principales:	Ningning Pan, Ke Zheng, Yanna Zhao, Dan Zhang, Changxu Dong, Junhai Xu, Xianglin Li, Yuanjie Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hippocampal formation shape analysis blindness plasticity spatial navigation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f9dc2ab6388c487291fca3fbc5f6e756
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spelling	oai:doaj.org-article:f9dc2ab6388c487291fca3fbc5f6e7562021-11-04T06:20:50ZMorphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals1662-453X10.3389/fnins.2021.715749https://doaj.org/article/f9dc2ab6388c487291fca3fbc5f6e7562021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.715749/fullhttps://doaj.org/toc/1662-453XThe detailed morphometry alterations of the human hippocampal formation (HF) for blind individuals are still understudied. 50 subjects were recruited from Yantai Affiliated Hospital of Binzhou Medical University, including 16 congenital blindness, 14 late blindness, and 20 sighted controls. Volume and shape analysis were conducted between the blind (congenital or late) and sighted groups to observe the (sub)regional alterations of the HF. No significant difference of the hippocampal volume was observed between the blind and sighted subjects. Rightward asymmetry of the hippocampal volume was found for both congenital and late blind individuals, while no significant hemispheric difference was observed for the sighted controls. Shape analysis showed that the superior and inferior parts of both the hippocampal head and tail expanded, while the medial and lateral parts constrained for the blind individuals as compared to the sighted controls. The morphometry alterations for the congenital blind and late blind individuals are nearly the same. Significant expansion of the superior part of the hippocampal tail for both congenital and late blind groups were observed for the left hippocampi after FDR correction. Current results suggest that the cross-model plastic may occur in both hemispheres of the HF to improve the navigation ability without the stimuli of visual cues, and the alteration is more prominent for the left hemisphere.Ningning PanNingning PanKe ZhengYanna ZhaoDan ZhangChangxu DongJunhai XuXianglin LiYuanjie ZhengFrontiers Media S.A.articlehippocampal formationshape analysisblindnessplasticityspatial navigationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hippocampal formation shape analysis blindness plasticity spatial navigation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	hippocampal formation shape analysis blindness plasticity spatial navigation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ningning Pan Ningning Pan Ke Zheng Yanna Zhao Dan Zhang Changxu Dong Junhai Xu Xianglin Li Yuanjie Zheng Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals
description	The detailed morphometry alterations of the human hippocampal formation (HF) for blind individuals are still understudied. 50 subjects were recruited from Yantai Affiliated Hospital of Binzhou Medical University, including 16 congenital blindness, 14 late blindness, and 20 sighted controls. Volume and shape analysis were conducted between the blind (congenital or late) and sighted groups to observe the (sub)regional alterations of the HF. No significant difference of the hippocampal volume was observed between the blind and sighted subjects. Rightward asymmetry of the hippocampal volume was found for both congenital and late blind individuals, while no significant hemispheric difference was observed for the sighted controls. Shape analysis showed that the superior and inferior parts of both the hippocampal head and tail expanded, while the medial and lateral parts constrained for the blind individuals as compared to the sighted controls. The morphometry alterations for the congenital blind and late blind individuals are nearly the same. Significant expansion of the superior part of the hippocampal tail for both congenital and late blind groups were observed for the left hippocampi after FDR correction. Current results suggest that the cross-model plastic may occur in both hemispheres of the HF to improve the navigation ability without the stimuli of visual cues, and the alteration is more prominent for the left hemisphere.
format	article
author	Ningning Pan Ningning Pan Ke Zheng Yanna Zhao Dan Zhang Changxu Dong Junhai Xu Xianglin Li Yuanjie Zheng
author_facet	Ningning Pan Ningning Pan Ke Zheng Yanna Zhao Dan Zhang Changxu Dong Junhai Xu Xianglin Li Yuanjie Zheng
author_sort	Ningning Pan
title	Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals
title_short	Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals
title_full	Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals
title_fullStr	Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals
title_full_unstemmed	Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals
title_sort	morphometry difference of the hippocampal formation between blind and sighted individuals
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f9dc2ab6388c487291fca3fbc5f6e756
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Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals

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