A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis

Abstract HLA-B*52 is an established genetic factor in Takayasu arteritis (TAK). Recently, single nucleotide polymorphisms (SNPs) in IL12B (rs6871626) and LILRA3 (rs103294) were newly identified as non-HLA susceptibility loci in TAK. Here, we examined how these SNPs contribute to clinical characteris...

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Autores principales:	Keiichiro Kadoba, Ryu Watanabe, Takeshi Iwasaki, Toshiki Nakajima, Koji Kitagori, Shuji Akizuki, Kosaku Murakami, Ran Nakashima, Motomu Hashimoto, Masao Tanaka, Koichiro Ohmura, Akio Morinobu, Chikashi Terao, Hajime Yoshifuji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9e1ab64075742b083494f7b8b797a97
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spelling	oai:doaj.org-article:f9e1ab64075742b083494f7b8b797a972021-12-02T18:18:44ZA susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis10.1038/s41598-021-93213-92045-2322https://doaj.org/article/f9e1ab64075742b083494f7b8b797a972021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93213-9https://doaj.org/toc/2045-2322Abstract HLA-B52 is an established genetic factor in Takayasu arteritis (TAK). Recently, single nucleotide polymorphisms (SNPs) in IL12B (rs6871626) and LILRA3 (rs103294) were newly identified as non-HLA susceptibility loci in TAK. Here, we examined how these SNPs contribute to clinical characteristics and vascular damage in TAK. We retrospectively reviewed the medical records of 99 TAK patients enrolled in our previous genome-wide association study, and whose genotypes for IL12B rs6871626, LILRA3 rs103294, and HLA-B52 were available. Incidence of aortic regurgitation (AR) was significantly associated with the A allele (risk allele) of IL12B rs6871626 (CC 42%, AC 61%, AA 81%; p = 0.0052; odds ratio [OR] 2.45), as well as with the incidence of hypertension (p = 0.049; OR 1.82) and the proportion of patients who underwent aortic valve replacement (p = 0.023; OR 3.64). Regarding vascular damage, there was positive correlation between the Takayasu Arteritis Damage Score and the A allele of IL12B rs6871626 (CC 3.42 ± 2.71, AC 4.06 ± 3.25, AA 6.00 ± 2.81; p = 0.0035; β = 1.35) and between the Vasculitis Damage Index and the A allele (CC 3.47 ± 1.98, AC 4.33 ± 2.40, AA 5.37 ± 2.22; p = 0.0054; β = 0.96). Contrarily, no correlation was found between LILRA3 rs103294 and vascular damage. In the present study, IL12B rs6871626 was associated with vascular damage in TAK, whereas LILRA3 rs103294 was not. Genotyping of IL12B rs6871626 may help to identify patients at risk of disease progression.Keiichiro KadobaRyu WatanabeTakeshi IwasakiToshiki NakajimaKoji KitagoriShuji AkizukiKosaku MurakamiRan NakashimaMotomu HashimotoMasao TanakaKoichiro OhmuraAkio MorinobuChikashi TeraoHajime YoshifujiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keiichiro Kadoba Ryu Watanabe Takeshi Iwasaki Toshiki Nakajima Koji Kitagori Shuji Akizuki Kosaku Murakami Ran Nakashima Motomu Hashimoto Masao Tanaka Koichiro Ohmura Akio Morinobu Chikashi Terao Hajime Yoshifuji A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis
description	Abstract HLA-B52 is an established genetic factor in Takayasu arteritis (TAK). Recently, single nucleotide polymorphisms (SNPs) in IL12B (rs6871626) and LILRA3 (rs103294) were newly identified as non-HLA susceptibility loci in TAK. Here, we examined how these SNPs contribute to clinical characteristics and vascular damage in TAK. We retrospectively reviewed the medical records of 99 TAK patients enrolled in our previous genome-wide association study, and whose genotypes for IL12B rs6871626, LILRA3 rs103294, and HLA-B52 were available. Incidence of aortic regurgitation (AR) was significantly associated with the A allele (risk allele) of IL12B rs6871626 (CC 42%, AC 61%, AA 81%; p = 0.0052; odds ratio [OR] 2.45), as well as with the incidence of hypertension (p = 0.049; OR 1.82) and the proportion of patients who underwent aortic valve replacement (p = 0.023; OR 3.64). Regarding vascular damage, there was positive correlation between the Takayasu Arteritis Damage Score and the A allele of IL12B rs6871626 (CC 3.42 ± 2.71, AC 4.06 ± 3.25, AA 6.00 ± 2.81; p = 0.0035; β = 1.35) and between the Vasculitis Damage Index and the A allele (CC 3.47 ± 1.98, AC 4.33 ± 2.40, AA 5.37 ± 2.22; p = 0.0054; β = 0.96). Contrarily, no correlation was found between LILRA3 rs103294 and vascular damage. In the present study, IL12B rs6871626 was associated with vascular damage in TAK, whereas LILRA3 rs103294 was not. Genotyping of IL12B rs6871626 may help to identify patients at risk of disease progression.
format	article
author	Keiichiro Kadoba Ryu Watanabe Takeshi Iwasaki Toshiki Nakajima Koji Kitagori Shuji Akizuki Kosaku Murakami Ran Nakashima Motomu Hashimoto Masao Tanaka Koichiro Ohmura Akio Morinobu Chikashi Terao Hajime Yoshifuji
author_facet	Keiichiro Kadoba Ryu Watanabe Takeshi Iwasaki Toshiki Nakajima Koji Kitagori Shuji Akizuki Kosaku Murakami Ran Nakashima Motomu Hashimoto Masao Tanaka Koichiro Ohmura Akio Morinobu Chikashi Terao Hajime Yoshifuji
author_sort	Keiichiro Kadoba
title	A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis
title_short	A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis
title_full	A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis
title_fullStr	A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis
title_full_unstemmed	A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis
title_sort	susceptibility locus in the il12b but not lilra3 region is associated with vascular damage in takayasu arteritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f9e1ab64075742b083494f7b8b797a97
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A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis

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