Ionization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis

Atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS) and electrospray ionization (ESI)-MS can cover the analysis of analytes from low to high polarities. Thus, an ion source that possesses these two ionization functions is useful. Atmospheric surface-assisted ionization (ASAI), whi...

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Autores principales:	De-Yi Huang, Meng-Jiy Wang, Jih-Jen Wu, Yu-Chie Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	titanium ESI APCI nonpolar volatile ambient ionization Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/f9e3d358013842e0b859a1914008d0fa
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spelling	oai:doaj.org-article:f9e3d358013842e0b859a1914008d0fa2021-11-25T18:27:02ZIonization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis10.3390/molecules262267601420-3049https://doaj.org/article/f9e3d358013842e0b859a1914008d0fa2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6760https://doaj.org/toc/1420-3049Atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS) and electrospray ionization (ESI)-MS can cover the analysis of analytes from low to high polarities. Thus, an ion source that possesses these two ionization functions is useful. Atmospheric surface-assisted ionization (ASAI), which can be used to ionize polar and nonpolar analytes in vapor, liquid, and solid forms, was demonstrated in this study. The ionization of analytes through APCI or ESI was induced from the surface of a metal substrate such as a titanium slab. ASAI is a contactless approach operated at atmospheric pressure. No electric contacts nor any voltages were required to be applied on the metal substrate during ionization. When placing samples with high vapor pressure in condensed phase underneath a titanium slab close to the inlet of the mass spectrometer, analytes can be readily ionized and detected by the mass spectrometer. Furthermore, a sample droplet (~2 μL) containing high-polarity analytes, including polar organics and biomolecules, was ionized using the titanium slab. One titanium slab is sufficient to induce the ionization of analytes occurring in front of a mass spectrometer applied with a high voltage. Moreover, this ionization method can be used to detect high volatile or polar analytes through APCI-like or ESI-like processes, respectively.De-Yi HuangMeng-Jiy WangJih-Jen WuYu-Chie ChenMDPI AGarticletitaniumESIAPCInonpolarvolatileambient ionizationOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6760, p 6760 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	titanium ESI APCI nonpolar volatile ambient ionization Organic chemistry QD241-441
spellingShingle	titanium ESI APCI nonpolar volatile ambient ionization Organic chemistry QD241-441 De-Yi Huang Meng-Jiy Wang Jih-Jen Wu Yu-Chie Chen Ionization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis
description	Atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS) and electrospray ionization (ESI)-MS can cover the analysis of analytes from low to high polarities. Thus, an ion source that possesses these two ionization functions is useful. Atmospheric surface-assisted ionization (ASAI), which can be used to ionize polar and nonpolar analytes in vapor, liquid, and solid forms, was demonstrated in this study. The ionization of analytes through APCI or ESI was induced from the surface of a metal substrate such as a titanium slab. ASAI is a contactless approach operated at atmospheric pressure. No electric contacts nor any voltages were required to be applied on the metal substrate during ionization. When placing samples with high vapor pressure in condensed phase underneath a titanium slab close to the inlet of the mass spectrometer, analytes can be readily ionized and detected by the mass spectrometer. Furthermore, a sample droplet (~2 μL) containing high-polarity analytes, including polar organics and biomolecules, was ionized using the titanium slab. One titanium slab is sufficient to induce the ionization of analytes occurring in front of a mass spectrometer applied with a high voltage. Moreover, this ionization method can be used to detect high volatile or polar analytes through APCI-like or ESI-like processes, respectively.
format	article
author	De-Yi Huang Meng-Jiy Wang Jih-Jen Wu Yu-Chie Chen
author_facet	De-Yi Huang Meng-Jiy Wang Jih-Jen Wu Yu-Chie Chen
author_sort	De-Yi Huang
title	Ionization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis
title_short	Ionization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis
title_full	Ionization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis
title_fullStr	Ionization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis
title_full_unstemmed	Ionization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis
title_sort	ionization of volatile organics and nonvolatile biomolecules directly from a titanium slab for mass spectrometric analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f9e3d358013842e0b859a1914008d0fa
work_keys_str_mv	AT deyihuang ionizationofvolatileorganicsandnonvolatilebiomoleculesdirectlyfromatitaniumslabformassspectrometricanalysis AT mengjiywang ionizationofvolatileorganicsandnonvolatilebiomoleculesdirectlyfromatitaniumslabformassspectrometricanalysis AT jihjenwu ionizationofvolatileorganicsandnonvolatilebiomoleculesdirectlyfromatitaniumslabformassspectrometricanalysis AT yuchiechen ionizationofvolatileorganicsandnonvolatilebiomoleculesdirectlyfromatitaniumslabformassspectrometricanalysis
_version_	1718411173665177600

Ionization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis

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