Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease

Objective: To review and evaluate outcomes of patients with aspirin-exacerbated respiratory disease (AERD) following endoscopic sinus surgery and subsequent aspirin desensitization. Methods: Electronic searches of OVID MEDLINE (1948 to September 10, 2019), EMBASE (1980 to September 10, 2019), and Pu...

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Autores principales:	Lindsey Ryan, Daniel Segarra, Mark Tabor, Arjun Parasher
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	AERD Aspirin-exacerbated respiratory disease Aspirin desensitization Endoscopic sinus surgery Nasal polyps Chronic sinusitis with nasal polyps Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/f9e53b1eb14946ba97aa8ff5979679fc
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spelling	oai:doaj.org-article:f9e53b1eb14946ba97aa8ff5979679fc2021-12-02T14:18:28ZSystematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease2095-881110.1016/j.wjorl.2020.07.010https://doaj.org/article/f9e53b1eb14946ba97aa8ff5979679fc2020-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881120301414https://doaj.org/toc/2095-8811Objective: To review and evaluate outcomes of patients with aspirin-exacerbated respiratory disease (AERD) following endoscopic sinus surgery and subsequent aspirin desensitization. Methods: Electronic searches of OVID MEDLINE (1948 to September 10, 2019), EMBASE (1980 to September 10, 2019), and PubMed were performed on September 10, 2019. A systematic review of the literature was performed using the 2009 PRISMA guidelines. Studies with both preoperative and postoperative data for patients with AERD who underwent sinus surgery and aspirin desensitization were considered appropriate for inclusion. Publications were written in English and included patients aged 18 years or older. Results: Six studies met inclusion criteria for this systematic review. The primary outcome measure was change in symptom profile measured by patient-reported quality of life scores. The results demonstrate statistically significant improvement in symptoms following endoscopic sinus surgery, with sustained improvement following aspirin desensitization. Revision surgery rates were significantly lower in patients maintained on aspirin therapy. Conclusion: This review suggests that surgery followed by aspirin desensitization results in improvement in both subjective and objective outcome measures. The adjunctive use of aspirin desensitization allows for long-term stability in symptom scores. Recurrence of polyps and worsening symptoms requiring revision surgery occurs when aspirin maintenance therapy is interrupted.Lindsey RyanDaniel SegarraMark TaborArjun ParasherKeAi Communications Co., Ltd.articleAERDAspirin-exacerbated respiratory diseaseAspirin desensitizationEndoscopic sinus surgeryNasal polypsChronic sinusitis with nasal polypsOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 6, Iss 4, Pp 220-229 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	AERD Aspirin-exacerbated respiratory disease Aspirin desensitization Endoscopic sinus surgery Nasal polyps Chronic sinusitis with nasal polyps Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	AERD Aspirin-exacerbated respiratory disease Aspirin desensitization Endoscopic sinus surgery Nasal polyps Chronic sinusitis with nasal polyps Otorhinolaryngology RF1-547 Surgery RD1-811 Lindsey Ryan Daniel Segarra Mark Tabor Arjun Parasher Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease
description	Objective: To review and evaluate outcomes of patients with aspirin-exacerbated respiratory disease (AERD) following endoscopic sinus surgery and subsequent aspirin desensitization. Methods: Electronic searches of OVID MEDLINE (1948 to September 10, 2019), EMBASE (1980 to September 10, 2019), and PubMed were performed on September 10, 2019. A systematic review of the literature was performed using the 2009 PRISMA guidelines. Studies with both preoperative and postoperative data for patients with AERD who underwent sinus surgery and aspirin desensitization were considered appropriate for inclusion. Publications were written in English and included patients aged 18 years or older. Results: Six studies met inclusion criteria for this systematic review. The primary outcome measure was change in symptom profile measured by patient-reported quality of life scores. The results demonstrate statistically significant improvement in symptoms following endoscopic sinus surgery, with sustained improvement following aspirin desensitization. Revision surgery rates were significantly lower in patients maintained on aspirin therapy. Conclusion: This review suggests that surgery followed by aspirin desensitization results in improvement in both subjective and objective outcome measures. The adjunctive use of aspirin desensitization allows for long-term stability in symptom scores. Recurrence of polyps and worsening symptoms requiring revision surgery occurs when aspirin maintenance therapy is interrupted.
format	article
author	Lindsey Ryan Daniel Segarra Mark Tabor Arjun Parasher
author_facet	Lindsey Ryan Daniel Segarra Mark Tabor Arjun Parasher
author_sort	Lindsey Ryan
title	Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease
title_short	Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease
title_full	Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease
title_fullStr	Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease
title_full_unstemmed	Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease
title_sort	systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/f9e53b1eb14946ba97aa8ff5979679fc
work_keys_str_mv	AT lindseyryan systematicreviewofoutcomesforendoscopicsinussurgeryandsubsequentaspirindesensitizationinaspirinexacerbatedrespiratorydisease AT danielsegarra systematicreviewofoutcomesforendoscopicsinussurgeryandsubsequentaspirindesensitizationinaspirinexacerbatedrespiratorydisease AT marktabor systematicreviewofoutcomesforendoscopicsinussurgeryandsubsequentaspirindesensitizationinaspirinexacerbatedrespiratorydisease AT arjunparasher systematicreviewofoutcomesforendoscopicsinussurgeryandsubsequentaspirindesensitizationinaspirinexacerbatedrespiratorydisease
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Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease

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