Risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction

Abstract Radical cystectomy, which is a standard treatment of muscle invasive and high-grade non-invasive bladder tumour, is accompanied with high rates of postoperative complications including major adverse cardiac events (MACE). Diastolic dysfunction is associated with postoperative complications....

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Autores principales:	In-Jung Jun, Junghwa Kim, Hyun-Gyu Kim, Gi-Ho Koh, Jai-Hyun Hwang, Young-Kug Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9e5c10bf502474293f855a5f53edbc0
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spelling	oai:doaj.org-article:f9e5c10bf502474293f855a5f53edbc02021-12-02T15:09:13ZRisk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction10.1038/s41598-019-50582-62045-2322https://doaj.org/article/f9e5c10bf502474293f855a5f53edbc02019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-50582-6https://doaj.org/toc/2045-2322Abstract Radical cystectomy, which is a standard treatment of muscle invasive and high-grade non-invasive bladder tumour, is accompanied with high rates of postoperative complications including major adverse cardiac events (MACE). Diastolic dysfunction is associated with postoperative complications. We evaluated perioperative risk factors including diastolic dysfunction related with MACE within 6 months after radical cystectomy. The 546 patients who underwent elective radical cystectomy were included. Diastolic dysfunction was defined as early transmitral flow velocity (E)/early diastolic mitral annulus velocity (e′) > 15. Logistic regression analysis, Kaplan-Meier survival analysis and log-rank test were performed. MACE within 6 months after radical cystectomy developed in 43 (7.9%) patients. MACE was related with female (odds ratio 2.546, 95% confidence interval 1.166–5.557, P = 0.019) and diastolic dysfunction (odds ratio 3.077, 95% confidence interval 1.147–8.252, P = 0.026). The 6-month mortality were significantly higher in the MACE group, and hospital stay and intensive care unit stay were significantly longer in the MACE group compared to the non-MACE group. Accordingly, preoperative diastolic dysfunction (E/e′ > 15) was related with postoperative MACE and MACE was related with 6-month survival after radical cystectomy. These results suggest that preoperative diastolic dysfunction can provide useful information on postoperative complications.In-Jung JunJunghwa KimHyun-Gyu KimGi-Ho KohJai-Hyun HwangYoung-Kug KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q In-Jung Jun Junghwa Kim Hyun-Gyu Kim Gi-Ho Koh Jai-Hyun Hwang Young-Kug Kim Risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction
description	Abstract Radical cystectomy, which is a standard treatment of muscle invasive and high-grade non-invasive bladder tumour, is accompanied with high rates of postoperative complications including major adverse cardiac events (MACE). Diastolic dysfunction is associated with postoperative complications. We evaluated perioperative risk factors including diastolic dysfunction related with MACE within 6 months after radical cystectomy. The 546 patients who underwent elective radical cystectomy were included. Diastolic dysfunction was defined as early transmitral flow velocity (E)/early diastolic mitral annulus velocity (e′) > 15. Logistic regression analysis, Kaplan-Meier survival analysis and log-rank test were performed. MACE within 6 months after radical cystectomy developed in 43 (7.9%) patients. MACE was related with female (odds ratio 2.546, 95% confidence interval 1.166–5.557, P = 0.019) and diastolic dysfunction (odds ratio 3.077, 95% confidence interval 1.147–8.252, P = 0.026). The 6-month mortality were significantly higher in the MACE group, and hospital stay and intensive care unit stay were significantly longer in the MACE group compared to the non-MACE group. Accordingly, preoperative diastolic dysfunction (E/e′ > 15) was related with postoperative MACE and MACE was related with 6-month survival after radical cystectomy. These results suggest that preoperative diastolic dysfunction can provide useful information on postoperative complications.
format	article
author	In-Jung Jun Junghwa Kim Hyun-Gyu Kim Gi-Ho Koh Jai-Hyun Hwang Young-Kug Kim
author_facet	In-Jung Jun Junghwa Kim Hyun-Gyu Kim Gi-Ho Koh Jai-Hyun Hwang Young-Kug Kim
author_sort	In-Jung Jun
title	Risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction
title_short	Risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction
title_full	Risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction
title_fullStr	Risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction
title_full_unstemmed	Risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction
title_sort	risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f9e5c10bf502474293f855a5f53edbc0
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Risk factors of postoperative major adverse cardiac events after radical cystectomy: implication of diastolic dysfunction

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