Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.

<h4>Background</h4>Antipsychotic agents are the basis for the pharmacological management of acute and chronic schizophrenia, bipolar disorders, mood disorders with psychotic feature, and other psychotic disorders. Antipsychotic medication use is frequently associated with unfavorable adv...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tilahun Ali, Mekonnen Sisay, Mandaras Tariku, Abraham Nigussie Mekuria, Assefa Desalew
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9e5cb8532c6402696efdd0f403091e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f9e5cb8532c6402696efdd0f403091e4
record_format	dspace
spelling	oai:doaj.org-article:f9e5cb8532c6402696efdd0f403091e42021-12-02T20:08:19ZAntipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.1932-620310.1371/journal.pone.0257129https://doaj.org/article/f9e5cb8532c6402696efdd0f403091e42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257129https://doaj.org/toc/1932-6203<h4>Background</h4>Antipsychotic agents are the basis for the pharmacological management of acute and chronic schizophrenia, bipolar disorders, mood disorders with psychotic feature, and other psychotic disorders. Antipsychotic medication use is frequently associated with unfavorable adverse effects such as extrapyramidal side effects (EPSEs). Hence, this systematic review and meta-analysis was aimed to determine the magnitude of antipsychotic-induced EPSEs.<h4>Method</h4>A literature search was conducted using legitimate databases, indexing services, and directories including PubMed/MEDLINE (Ovid®), EMBASE (Ovid®), google scholar and WorldCat to retrieve studies. Following screening and eligibility, the relevant data were extracted from the included studies using an Excel sheet and exported to STATA 15.0 software for analyses. The Random effects pooling model was used to analyze outcome measures at a 95% confidence interval. Besides, publication bias analysis was conducted. The protocol has been registered on PROSPERO with ID: CRD42020175168.<h4>Result</h4>In total, 15 original articles were included for the systematic review and meta-analysis. The pooled prevalence of antipsychotic-induced EPSEs among patient taking antipsychotic medications was 37% (95% CI: 18-55%, before sensitivity) and 31% (95% CI: 19-44%, after sensitivity). The prevalence of antipsychotic-induced parkinsonism, akathisia, and tardive dyskinesia was 20% (95% CI: 11-28%), 11% (95% CI: 6-17%), and 7% (95% CI: 4-9%), respectively. To confirm a small-study effect, Egger's regression test accompanied by funnel plot asymmetry demonstrated that there was a sort of publication bias in studies reporting akathisia and tardive dyskinesia.<h4>Conclusion</h4>The prevalence of antipsychotic-induced EPSEs was considerably high. One in five and more than one in ten patients experienced parkinsonism and akathisia, respectively. Appropriate prevention and early management of these effects can enhance the net benefits of antipsychotics.Tilahun AliMekonnen SisayMandaras TarikuAbraham Nigussie MekuriaAssefa DesalewPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257129 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tilahun Ali Mekonnen Sisay Mandaras Tariku Abraham Nigussie Mekuria Assefa Desalew Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.
description	<h4>Background</h4>Antipsychotic agents are the basis for the pharmacological management of acute and chronic schizophrenia, bipolar disorders, mood disorders with psychotic feature, and other psychotic disorders. Antipsychotic medication use is frequently associated with unfavorable adverse effects such as extrapyramidal side effects (EPSEs). Hence, this systematic review and meta-analysis was aimed to determine the magnitude of antipsychotic-induced EPSEs.<h4>Method</h4>A literature search was conducted using legitimate databases, indexing services, and directories including PubMed/MEDLINE (Ovid®), EMBASE (Ovid®), google scholar and WorldCat to retrieve studies. Following screening and eligibility, the relevant data were extracted from the included studies using an Excel sheet and exported to STATA 15.0 software for analyses. The Random effects pooling model was used to analyze outcome measures at a 95% confidence interval. Besides, publication bias analysis was conducted. The protocol has been registered on PROSPERO with ID: CRD42020175168.<h4>Result</h4>In total, 15 original articles were included for the systematic review and meta-analysis. The pooled prevalence of antipsychotic-induced EPSEs among patient taking antipsychotic medications was 37% (95% CI: 18-55%, before sensitivity) and 31% (95% CI: 19-44%, after sensitivity). The prevalence of antipsychotic-induced parkinsonism, akathisia, and tardive dyskinesia was 20% (95% CI: 11-28%), 11% (95% CI: 6-17%), and 7% (95% CI: 4-9%), respectively. To confirm a small-study effect, Egger's regression test accompanied by funnel plot asymmetry demonstrated that there was a sort of publication bias in studies reporting akathisia and tardive dyskinesia.<h4>Conclusion</h4>The prevalence of antipsychotic-induced EPSEs was considerably high. One in five and more than one in ten patients experienced parkinsonism and akathisia, respectively. Appropriate prevention and early management of these effects can enhance the net benefits of antipsychotics.
format	article
author	Tilahun Ali Mekonnen Sisay Mandaras Tariku Abraham Nigussie Mekuria Assefa Desalew
author_facet	Tilahun Ali Mekonnen Sisay Mandaras Tariku Abraham Nigussie Mekuria Assefa Desalew
author_sort	Tilahun Ali
title	Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.
title_short	Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.
title_full	Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.
title_fullStr	Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.
title_full_unstemmed	Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.
title_sort	antipsychotic-induced extrapyramidal side effects: a systematic review and meta-analysis of observational studies.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f9e5cb8532c6402696efdd0f403091e4
work_keys_str_mv	AT tilahunali antipsychoticinducedextrapyramidalsideeffectsasystematicreviewandmetaanalysisofobservationalstudies AT mekonnensisay antipsychoticinducedextrapyramidalsideeffectsasystematicreviewandmetaanalysisofobservationalstudies AT mandarastariku antipsychoticinducedextrapyramidalsideeffectsasystematicreviewandmetaanalysisofobservationalstudies AT abrahamnigussiemekuria antipsychoticinducedextrapyramidalsideeffectsasystematicreviewandmetaanalysisofobservationalstudies AT assefadesalew antipsychoticinducedextrapyramidalsideeffectsasystematicreviewandmetaanalysisofobservationalstudies
_version_	1718375218906398720

Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.

Ejemplares similares