Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

Previous work showed that the caspase 1 inhibitor VX-765 rescued cognitive deficits in the J20 mouse model of Alzheimer’s disease, and this may occur via reduced inflammation. Here the authors show that administration of the drug prior to onset of cognitive deficits and pathology in mice delays the...

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Autores principales:	Joseph Flores, Anastasia Noël, Bénédicte Foveau, Olivier Beauchet, Andréa C. LeBlanc
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f9e708e8e4a94657bdc8e388bc81fd42
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spelling	oai:doaj.org-article:f9e708e8e4a94657bdc8e388bc81fd422021-12-02T17:42:11ZPre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging10.1038/s41467-020-18405-92041-1723https://doaj.org/article/f9e708e8e4a94657bdc8e388bc81fd422020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18405-9https://doaj.org/toc/2041-1723Previous work showed that the caspase 1 inhibitor VX-765 rescued cognitive deficits in the J20 mouse model of Alzheimer’s disease, and this may occur via reduced inflammation. Here the authors show that administration of the drug prior to onset of cognitive deficits and pathology in mice delays the onset of deficits.Joseph FloresAnastasia NoëlBénédicte FoveauOlivier BeauchetAndréa C. LeBlancNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph Flores Anastasia Noël Bénédicte Foveau Olivier Beauchet Andréa C. LeBlanc Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging
description	Previous work showed that the caspase 1 inhibitor VX-765 rescued cognitive deficits in the J20 mouse model of Alzheimer’s disease, and this may occur via reduced inflammation. Here the authors show that administration of the drug prior to onset of cognitive deficits and pathology in mice delays the onset of deficits.
format	article
author	Joseph Flores Anastasia Noël Bénédicte Foveau Olivier Beauchet Andréa C. LeBlanc
author_facet	Joseph Flores Anastasia Noël Bénédicte Foveau Olivier Beauchet Andréa C. LeBlanc
author_sort	Joseph Flores
title	Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging
title_short	Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging
title_full	Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging
title_fullStr	Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging
title_full_unstemmed	Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging
title_sort	pre-symptomatic caspase-1 inhibitor delays cognitive decline in a mouse model of alzheimer disease and aging
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f9e708e8e4a94657bdc8e388bc81fd42
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Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

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