Nuclear-resident RIG-I senses viral replication inducing antiviral immunity

RIG-I senses cytoplasmic viral RNA, resulting in induction of an antiviral response. Here, the authors identify nuclear RIG-I and show that it binds nuclear influenza A virus RNA, resulting in a cooperative interferon induction along with its cytoplasmic counterpart.

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Auteurs principaux:	GuanQun Liu, Yao Lu, Sathya N. Thulasi Raman, Fang Xu, Qi Wu, Zhubing Li, Robert Brownlie, Qiang Liu, Yan Zhou
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f9f0aa1f28d042be8ac6b3988ac72a18
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spelling	oai:doaj.org-article:f9f0aa1f28d042be8ac6b3988ac72a182021-12-02T17:31:46ZNuclear-resident RIG-I senses viral replication inducing antiviral immunity10.1038/s41467-018-05745-w2041-1723https://doaj.org/article/f9f0aa1f28d042be8ac6b3988ac72a182018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05745-whttps://doaj.org/toc/2041-1723RIG-I senses cytoplasmic viral RNA, resulting in induction of an antiviral response. Here, the authors identify nuclear RIG-I and show that it binds nuclear influenza A virus RNA, resulting in a cooperative interferon induction along with its cytoplasmic counterpart.GuanQun LiuYao LuSathya N. Thulasi RamanFang XuQi WuZhubing LiRobert BrownlieQiang LiuYan ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q GuanQun Liu Yao Lu Sathya N. Thulasi Raman Fang Xu Qi Wu Zhubing Li Robert Brownlie Qiang Liu Yan Zhou Nuclear-resident RIG-I senses viral replication inducing antiviral immunity
description	RIG-I senses cytoplasmic viral RNA, resulting in induction of an antiviral response. Here, the authors identify nuclear RIG-I and show that it binds nuclear influenza A virus RNA, resulting in a cooperative interferon induction along with its cytoplasmic counterpart.
format	article
author	GuanQun Liu Yao Lu Sathya N. Thulasi Raman Fang Xu Qi Wu Zhubing Li Robert Brownlie Qiang Liu Yan Zhou
author_facet	GuanQun Liu Yao Lu Sathya N. Thulasi Raman Fang Xu Qi Wu Zhubing Li Robert Brownlie Qiang Liu Yan Zhou
author_sort	GuanQun Liu
title	Nuclear-resident RIG-I senses viral replication inducing antiviral immunity
title_short	Nuclear-resident RIG-I senses viral replication inducing antiviral immunity
title_full	Nuclear-resident RIG-I senses viral replication inducing antiviral immunity
title_fullStr	Nuclear-resident RIG-I senses viral replication inducing antiviral immunity
title_full_unstemmed	Nuclear-resident RIG-I senses viral replication inducing antiviral immunity
title_sort	nuclear-resident rig-i senses viral replication inducing antiviral immunity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f9f0aa1f28d042be8ac6b3988ac72a18
work_keys_str_mv	AT guanqunliu nuclearresidentrigisensesviralreplicationinducingantiviralimmunity AT yaolu nuclearresidentrigisensesviralreplicationinducingantiviralimmunity AT sathyanthulasiraman nuclearresidentrigisensesviralreplicationinducingantiviralimmunity AT fangxu nuclearresidentrigisensesviralreplicationinducingantiviralimmunity AT qiwu nuclearresidentrigisensesviralreplicationinducingantiviralimmunity AT zhubingli nuclearresidentrigisensesviralreplicationinducingantiviralimmunity AT robertbrownlie nuclearresidentrigisensesviralreplicationinducingantiviralimmunity AT qiangliu nuclearresidentrigisensesviralreplicationinducingantiviralimmunity AT yanzhou nuclearresidentrigisensesviralreplicationinducingantiviralimmunity
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Nuclear-resident RIG-I senses viral replication inducing antiviral immunity

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