A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.

Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy con...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Savas Ustunova, Ebru Haciosmanoglu, Huri Bulut, Birsen Elibol, Aysu Kilic, Rumeysa Hekimoglu, Serkan Tunc, Rabia Atmaca, Irem Kaygusuz, Sevil Tunc, Gulcin Beyza Tunc, Ismail Meral
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9f1ab77792140dfad7b98828965ed00
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f9f1ab77792140dfad7b98828965ed00
record_format	dspace
spelling	oai:doaj.org-article:f9f1ab77792140dfad7b98828965ed002021-12-02T20:08:23ZA low direct electrical signal attenuates oxidative stress and inflammation in septic rats.1932-620310.1371/journal.pone.0257177https://doaj.org/article/f9f1ab77792140dfad7b98828965ed002021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257177https://doaj.org/toc/1932-6203Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE) groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating changes in the histological structure of tissues, blood pH, gases, viscosity and cell count, activities of some important enzymes, oxidative stress parameters, inflammation and tissue apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.Savas UstunovaEbru HaciosmanogluHuri BulutBirsen ElibolAysu KilicRumeysa HekimogluSerkan TuncRabia AtmacaIrem KaygusuzSevil TuncGulcin Beyza TuncIsmail MeralPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257177 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Savas Ustunova Ebru Haciosmanoglu Huri Bulut Birsen Elibol Aysu Kilic Rumeysa Hekimoglu Serkan Tunc Rabia Atmaca Irem Kaygusuz Sevil Tunc Gulcin Beyza Tunc Ismail Meral A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.
description	Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE) groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating changes in the histological structure of tissues, blood pH, gases, viscosity and cell count, activities of some important enzymes, oxidative stress parameters, inflammation and tissue apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.
format	article
author	Savas Ustunova Ebru Haciosmanoglu Huri Bulut Birsen Elibol Aysu Kilic Rumeysa Hekimoglu Serkan Tunc Rabia Atmaca Irem Kaygusuz Sevil Tunc Gulcin Beyza Tunc Ismail Meral
author_facet	Savas Ustunova Ebru Haciosmanoglu Huri Bulut Birsen Elibol Aysu Kilic Rumeysa Hekimoglu Serkan Tunc Rabia Atmaca Irem Kaygusuz Sevil Tunc Gulcin Beyza Tunc Ismail Meral
author_sort	Savas Ustunova
title	A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.
title_short	A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.
title_full	A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.
title_fullStr	A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.
title_full_unstemmed	A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.
title_sort	low direct electrical signal attenuates oxidative stress and inflammation in septic rats.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f9f1ab77792140dfad7b98828965ed00
work_keys_str_mv	AT savasustunova alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT ebruhaciosmanoglu alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT huribulut alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT birsenelibol alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT aysukilic alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT rumeysahekimoglu alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT serkantunc alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT rabiaatmaca alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT iremkaygusuz alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT seviltunc alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT gulcinbeyzatunc alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT ismailmeral alowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT savasustunova lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT ebruhaciosmanoglu lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT huribulut lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT birsenelibol lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT aysukilic lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT rumeysahekimoglu lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT serkantunc lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT rabiaatmaca lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT iremkaygusuz lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT seviltunc lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT gulcinbeyzatunc lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats AT ismailmeral lowdirectelectricalsignalattenuatesoxidativestressandinflammationinsepticrats
_version_	1718375219141279744

A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.

Ejemplares similares