Caspase-11 promotes allergic airway inflammation

Caspase 11 activation involves transcriptional upregulation and proteolytic cleavage. Here the authors show that prostaglandin E2 prevents caspase-11-mediated pyroptosis, blocking caspase-11 mRNA and protein upregulation in macrophages and in vivo, and that mice lacking caspase-11 are strongly prote...

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Autores principales:	Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f9f58905287b4fe39d8a26ba82a9f274
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spelling	oai:doaj.org-article:f9f58905287b4fe39d8a26ba82a9f2742021-12-02T14:40:27ZCaspase-11 promotes allergic airway inflammation10.1038/s41467-020-14945-22041-1723https://doaj.org/article/f9f58905287b4fe39d8a26ba82a9f2742020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14945-2https://doaj.org/toc/2041-1723Caspase 11 activation involves transcriptional upregulation and proteolytic cleavage. Here the authors show that prostaglandin E2 prevents caspase-11-mediated pyroptosis, blocking caspase-11 mRNA and protein upregulation in macrophages and in vivo, and that mice lacking caspase-11 are strongly protected from allergic airway inflammation.Zbigniew ZasłonaEwelina FlisMieszko M. WilkRichard G. CarrollEva M. Palsson-McDermottMark M. HughesCiana DiskinKathy BanahanDylan G. RyanAlexander HooftmanAlicja MisiakJay KearneyGunter LochnitWilhelm BertramsTimm GreulichBernd SchmeckOliver J. McElvaneyKingston H. G. MillsEd C. LavelleMałgorzata WygreckaEmma M. CreaghLuke A. J. O’NeillNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zbigniew Zasłona Ewelina Flis Mieszko M. Wilk Richard G. Carroll Eva M. Palsson-McDermott Mark M. Hughes Ciana Diskin Kathy Banahan Dylan G. Ryan Alexander Hooftman Alicja Misiak Jay Kearney Gunter Lochnit Wilhelm Bertrams Timm Greulich Bernd Schmeck Oliver J. McElvaney Kingston H. G. Mills Ed C. Lavelle Małgorzata Wygrecka Emma M. Creagh Luke A. J. O’Neill Caspase-11 promotes allergic airway inflammation
description	Caspase 11 activation involves transcriptional upregulation and proteolytic cleavage. Here the authors show that prostaglandin E2 prevents caspase-11-mediated pyroptosis, blocking caspase-11 mRNA and protein upregulation in macrophages and in vivo, and that mice lacking caspase-11 are strongly protected from allergic airway inflammation.
format	article
author	Zbigniew Zasłona Ewelina Flis Mieszko M. Wilk Richard G. Carroll Eva M. Palsson-McDermott Mark M. Hughes Ciana Diskin Kathy Banahan Dylan G. Ryan Alexander Hooftman Alicja Misiak Jay Kearney Gunter Lochnit Wilhelm Bertrams Timm Greulich Bernd Schmeck Oliver J. McElvaney Kingston H. G. Mills Ed C. Lavelle Małgorzata Wygrecka Emma M. Creagh Luke A. J. O’Neill
author_facet	Zbigniew Zasłona Ewelina Flis Mieszko M. Wilk Richard G. Carroll Eva M. Palsson-McDermott Mark M. Hughes Ciana Diskin Kathy Banahan Dylan G. Ryan Alexander Hooftman Alicja Misiak Jay Kearney Gunter Lochnit Wilhelm Bertrams Timm Greulich Bernd Schmeck Oliver J. McElvaney Kingston H. G. Mills Ed C. Lavelle Małgorzata Wygrecka Emma M. Creagh Luke A. J. O’Neill
author_sort	Zbigniew Zasłona
title	Caspase-11 promotes allergic airway inflammation
title_short	Caspase-11 promotes allergic airway inflammation
title_full	Caspase-11 promotes allergic airway inflammation
title_fullStr	Caspase-11 promotes allergic airway inflammation
title_full_unstemmed	Caspase-11 promotes allergic airway inflammation
title_sort	caspase-11 promotes allergic airway inflammation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f9f58905287b4fe39d8a26ba82a9f274
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Caspase-11 promotes allergic airway inflammation

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