Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease

Dysfunction of the gastrointestinal system, and to the autophagy lysososmal pathway (ALP) have been reported in Parkinson’s disease. Here the authors report epigenetic disruption of ALP related genes in the appendix of individuals with Parkinson’s disease.

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Autores principales:	Juozas Gordevicius, Peipei Li, Lee L. Marshall, Bryan A. Killinger, Sean Lang, Elizabeth Ensink, Nathan C. Kuhn, Wei Cui, Nazia Maroof, Roberta Lauria, Christina Rueb, Juliane Siebourg-Polster, Pierre Maliver, Jared Lamp, Irving Vega, Fredric P. Manfredsson, Markus Britschgi, Viviane Labrie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f9f6d09087434442861f49df6420270e
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spelling	oai:doaj.org-article:f9f6d09087434442861f49df6420270e2021-12-02T18:53:10ZEpigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease10.1038/s41467-021-25474-x2041-1723https://doaj.org/article/f9f6d09087434442861f49df6420270e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25474-xhttps://doaj.org/toc/2041-1723Dysfunction of the gastrointestinal system, and to the autophagy lysososmal pathway (ALP) have been reported in Parkinson’s disease. Here the authors report epigenetic disruption of ALP related genes in the appendix of individuals with Parkinson’s disease.Juozas GordeviciusPeipei LiLee L. MarshallBryan A. KillingerSean LangElizabeth EnsinkNathan C. KuhnWei CuiNazia MaroofRoberta LauriaChristina RuebJuliane Siebourg-PolsterPierre MaliverJared LampIrving VegaFredric P. ManfredssonMarkus BritschgiViviane LabrieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juozas Gordevicius Peipei Li Lee L. Marshall Bryan A. Killinger Sean Lang Elizabeth Ensink Nathan C. Kuhn Wei Cui Nazia Maroof Roberta Lauria Christina Rueb Juliane Siebourg-Polster Pierre Maliver Jared Lamp Irving Vega Fredric P. Manfredsson Markus Britschgi Viviane Labrie Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
description	Dysfunction of the gastrointestinal system, and to the autophagy lysososmal pathway (ALP) have been reported in Parkinson’s disease. Here the authors report epigenetic disruption of ALP related genes in the appendix of individuals with Parkinson’s disease.
format	article
author	Juozas Gordevicius Peipei Li Lee L. Marshall Bryan A. Killinger Sean Lang Elizabeth Ensink Nathan C. Kuhn Wei Cui Nazia Maroof Roberta Lauria Christina Rueb Juliane Siebourg-Polster Pierre Maliver Jared Lamp Irving Vega Fredric P. Manfredsson Markus Britschgi Viviane Labrie
author_facet	Juozas Gordevicius Peipei Li Lee L. Marshall Bryan A. Killinger Sean Lang Elizabeth Ensink Nathan C. Kuhn Wei Cui Nazia Maroof Roberta Lauria Christina Rueb Juliane Siebourg-Polster Pierre Maliver Jared Lamp Irving Vega Fredric P. Manfredsson Markus Britschgi Viviane Labrie
author_sort	Juozas Gordevicius
title	Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
title_short	Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
title_full	Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
title_fullStr	Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
title_full_unstemmed	Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
title_sort	epigenetic inactivation of the autophagy–lysosomal system in appendix in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f9f6d09087434442861f49df6420270e
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Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease

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