Self-Assembling Peptide-Based Hydrogels in Angiogenesis

Chaoshan Han,1,* Zhiwei Zhang,2,* Jiacheng Sun,1 Ke Li,3 Yangxin Li,4 Chuanlu Ren,5 Qingyou Meng,4 Junjie Yang1 1Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA; 2Department of Cardiothoracic Surgery,...

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Autores principales:	Han C, Zhang Z, Sun J, Li K, Li Y, Ren C, Meng Q, Yang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	self‐assembling peptide hydrogel angiogenesis survival retention Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f9fc24258d54444e87f798da8d01757b
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spelling	oai:doaj.org-article:f9fc24258d54444e87f798da8d01757b2021-12-02T15:12:06ZSelf-Assembling Peptide-Based Hydrogels in Angiogenesis1178-2013https://doaj.org/article/f9fc24258d54444e87f798da8d01757b2020-12-01T00:00:00Zhttps://www.dovepress.com/self-assembling-peptide-based-hydrogels-in-angiogenesis-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chaoshan Han,1,* Zhiwei Zhang,2,* Jiacheng Sun,1 Ke Li,3 Yangxin Li,4 Chuanlu Ren,5 Qingyou Meng,4 Junjie Yang1 1Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA; 2Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215006, People’s Republic of China; 3Department of Burn and Plastic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, People’s Republic of China; 4Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou 215006, People’s Republic of China; 5Department of Clinical Laboratory, The 904th Hospital of the People’s Liberation Army, Wuxi 214044, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junjie YangDepartment of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, 1670 University Blvd, Volker Hall G094Q, Birmingham, AL 35294, USATel +1 205 934-2798Email jjyang@uab.eduQingyou MengDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road 215006 SuzhouTel +86-512-6797-2072Fax +86 -512-6778-0100Email mengqy@163.comAbstract: Ischemic diseases, especially in the heart and the brain, have become a serious threat to human health. Growth factor and cell therapy are emerging as promising therapeutic strategies; however, their retention and sustainable functions in the injured tissue are limited. Self-assembling peptide (SAP)-based hydrogels, mimicking the extracellular matrix, are therefore introduced to encapsulate and controllably release cells, cell-derived exosomes or growth factors, thus promoting angiogenesis and tissue recovery after ischemia. We will summarize the classification, composition and structure of SAPs, and the influencing factors for SAP gelation. Moreover, we will describe the functionalized SAPs, and the combinatorial therapy of cells, exosomes or growth factors with functionalized SAPs for angiogenic process as well as its advantage in immunogenicity and injectability. Finally, an outlook on future directions and challenges is provided.Keywords: self‐assembling peptide, hydrogel, angiogenesis, survival, retentionHan CZhang ZSun JLi KLi YRen CMeng QYang JDove Medical Pressarticleself‐assembling peptidehydrogelangiogenesissurvivalretentionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 10257-10269 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	self‐assembling peptide hydrogel angiogenesis survival retention Medicine (General) R5-920
spellingShingle	self‐assembling peptide hydrogel angiogenesis survival retention Medicine (General) R5-920 Han C Zhang Z Sun J Li K Li Y Ren C Meng Q Yang J Self-Assembling Peptide-Based Hydrogels in Angiogenesis
description	Chaoshan Han,1,* Zhiwei Zhang,2,* Jiacheng Sun,1 Ke Li,3 Yangxin Li,4 Chuanlu Ren,5 Qingyou Meng,4 Junjie Yang1 1Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA; 2Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215006, People’s Republic of China; 3Department of Burn and Plastic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, People’s Republic of China; 4Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou 215006, People’s Republic of China; 5Department of Clinical Laboratory, The 904th Hospital of the People’s Liberation Army, Wuxi 214044, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junjie YangDepartment of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, 1670 University Blvd, Volker Hall G094Q, Birmingham, AL 35294, USATel +1 205 934-2798Email jjyang@uab.eduQingyou MengDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road 215006 SuzhouTel +86-512-6797-2072Fax +86 -512-6778-0100Email mengqy@163.comAbstract: Ischemic diseases, especially in the heart and the brain, have become a serious threat to human health. Growth factor and cell therapy are emerging as promising therapeutic strategies; however, their retention and sustainable functions in the injured tissue are limited. Self-assembling peptide (SAP)-based hydrogels, mimicking the extracellular matrix, are therefore introduced to encapsulate and controllably release cells, cell-derived exosomes or growth factors, thus promoting angiogenesis and tissue recovery after ischemia. We will summarize the classification, composition and structure of SAPs, and the influencing factors for SAP gelation. Moreover, we will describe the functionalized SAPs, and the combinatorial therapy of cells, exosomes or growth factors with functionalized SAPs for angiogenic process as well as its advantage in immunogenicity and injectability. Finally, an outlook on future directions and challenges is provided.Keywords: self‐assembling peptide, hydrogel, angiogenesis, survival, retention
format	article
author	Han C Zhang Z Sun J Li K Li Y Ren C Meng Q Yang J
author_facet	Han C Zhang Z Sun J Li K Li Y Ren C Meng Q Yang J
author_sort	Han C
title	Self-Assembling Peptide-Based Hydrogels in Angiogenesis
title_short	Self-Assembling Peptide-Based Hydrogels in Angiogenesis
title_full	Self-Assembling Peptide-Based Hydrogels in Angiogenesis
title_fullStr	Self-Assembling Peptide-Based Hydrogels in Angiogenesis
title_full_unstemmed	Self-Assembling Peptide-Based Hydrogels in Angiogenesis
title_sort	self-assembling peptide-based hydrogels in angiogenesis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f9fc24258d54444e87f798da8d01757b
work_keys_str_mv	AT hanc selfassemblingpeptidebasedhydrogelsinangiogenesis AT zhangz selfassemblingpeptidebasedhydrogelsinangiogenesis AT sunj selfassemblingpeptidebasedhydrogelsinangiogenesis AT lik selfassemblingpeptidebasedhydrogelsinangiogenesis AT liy selfassemblingpeptidebasedhydrogelsinangiogenesis AT renc selfassemblingpeptidebasedhydrogelsinangiogenesis AT mengq selfassemblingpeptidebasedhydrogelsinangiogenesis AT yangj selfassemblingpeptidebasedhydrogelsinangiogenesis
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Self-Assembling Peptide-Based Hydrogels in Angiogenesis

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