Serum urate and cardiovascular events in the DCCT/EDIC study

Abstract In type 2 diabetes, hyperuricemia is associated with cardiovascular disease (CVD) and the metabolic syndrome (MetS), but associations in type 1 diabetes (T1D) have not been well-defined. This study examined the relationships between serum urate (SU) concentrations, clinical and biochemical...

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Autores principales:	Alicia J. Jenkins, Barbara H. Braffett, Arpita Basu, Ionut Bebu, Samuel Dagogo-Jack, Trevor J. Orchard, Amisha Wallia, Maria F. Lopes-Virella, W. Timothy Garvey, John M. Lachin, Timothy J. Lyons, the DCCT/EDIC Research Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f9fee4388877495b97606fb3d560869c
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spelling	oai:doaj.org-article:f9fee4388877495b97606fb3d560869c2021-12-02T18:34:13ZSerum urate and cardiovascular events in the DCCT/EDIC study10.1038/s41598-021-90785-42045-2322https://doaj.org/article/f9fee4388877495b97606fb3d560869c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90785-4https://doaj.org/toc/2045-2322Abstract In type 2 diabetes, hyperuricemia is associated with cardiovascular disease (CVD) and the metabolic syndrome (MetS), but associations in type 1 diabetes (T1D) have not been well-defined. This study examined the relationships between serum urate (SU) concentrations, clinical and biochemical factors, and subsequent cardiovascular events in a well-characterized cohort of adults with T1D. In 973 participants with T1D in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC), associations were defined between SU, measured once in blood collected 1997–2000, and (a) concurrent MetS and (b) incident ‘any CVD’ and major adverse cardiovascular events (MACE) through 2013. SU was higher in men than women [mean (SD): 4.47 (0.99) vs. 3.39 (0.97) mg/dl, respectively, p < 0.0001], and was associated with MetS features in both (men: p = 0.0016; women: p < 0.0001). During follow-up, 110 participants (11%) experienced “any CVD”, and 53 (5%) a MACE. Analyzed by quartiles, SU was not associated with subsequent CVD or MACE. In women, SU as a continuous variable was associated with MACE (unadjusted HR: 1.52; 95% CI 1.07–2.16; p = 0.0211) even after adjustment for age and HbA1c (HR: 1.47; 95% CI 1.01–2.14; p = 0.0467). Predominantly normal range serum urate concentrations in T1D were higher in men than women and were associated with features of the MetS. In some analyses of women only, SU was associated with subsequent MACE. Routine measurement of SU to assess cardiovascular risk in T1D is not merited. Trial registration clinicaltrials.gov NCT00360815 and NCT00360893.Alicia J. JenkinsBarbara H. BraffettArpita BasuIonut BebuSamuel Dagogo-JackTrevor J. OrchardAmisha WalliaMaria F. Lopes-VirellaW. Timothy GarveyJohn M. LachinTimothy J. Lyonsthe DCCT/EDIC Research GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alicia J. Jenkins Barbara H. Braffett Arpita Basu Ionut Bebu Samuel Dagogo-Jack Trevor J. Orchard Amisha Wallia Maria F. Lopes-Virella W. Timothy Garvey John M. Lachin Timothy J. Lyons the DCCT/EDIC Research Group Serum urate and cardiovascular events in the DCCT/EDIC study
description	Abstract In type 2 diabetes, hyperuricemia is associated with cardiovascular disease (CVD) and the metabolic syndrome (MetS), but associations in type 1 diabetes (T1D) have not been well-defined. This study examined the relationships between serum urate (SU) concentrations, clinical and biochemical factors, and subsequent cardiovascular events in a well-characterized cohort of adults with T1D. In 973 participants with T1D in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC), associations were defined between SU, measured once in blood collected 1997–2000, and (a) concurrent MetS and (b) incident ‘any CVD’ and major adverse cardiovascular events (MACE) through 2013. SU was higher in men than women [mean (SD): 4.47 (0.99) vs. 3.39 (0.97) mg/dl, respectively, p < 0.0001], and was associated with MetS features in both (men: p = 0.0016; women: p < 0.0001). During follow-up, 110 participants (11%) experienced “any CVD”, and 53 (5%) a MACE. Analyzed by quartiles, SU was not associated with subsequent CVD or MACE. In women, SU as a continuous variable was associated with MACE (unadjusted HR: 1.52; 95% CI 1.07–2.16; p = 0.0211) even after adjustment for age and HbA1c (HR: 1.47; 95% CI 1.01–2.14; p = 0.0467). Predominantly normal range serum urate concentrations in T1D were higher in men than women and were associated with features of the MetS. In some analyses of women only, SU was associated with subsequent MACE. Routine measurement of SU to assess cardiovascular risk in T1D is not merited. Trial registration clinicaltrials.gov NCT00360815 and NCT00360893.
format	article
author	Alicia J. Jenkins Barbara H. Braffett Arpita Basu Ionut Bebu Samuel Dagogo-Jack Trevor J. Orchard Amisha Wallia Maria F. Lopes-Virella W. Timothy Garvey John M. Lachin Timothy J. Lyons the DCCT/EDIC Research Group
author_facet	Alicia J. Jenkins Barbara H. Braffett Arpita Basu Ionut Bebu Samuel Dagogo-Jack Trevor J. Orchard Amisha Wallia Maria F. Lopes-Virella W. Timothy Garvey John M. Lachin Timothy J. Lyons the DCCT/EDIC Research Group
author_sort	Alicia J. Jenkins
title	Serum urate and cardiovascular events in the DCCT/EDIC study
title_short	Serum urate and cardiovascular events in the DCCT/EDIC study
title_full	Serum urate and cardiovascular events in the DCCT/EDIC study
title_fullStr	Serum urate and cardiovascular events in the DCCT/EDIC study
title_full_unstemmed	Serum urate and cardiovascular events in the DCCT/EDIC study
title_sort	serum urate and cardiovascular events in the dcct/edic study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f9fee4388877495b97606fb3d560869c
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Serum urate and cardiovascular events in the DCCT/EDIC study

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