Targeting lysosomes in human disease: from basic research to clinical applications

Abstract In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have been correlated with the development of numerous diseases. In this review, we interpreted the key biological func...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mengdie Cao, Xiangyuan Luo, Kongming Wu, Xingxing He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f9ff10764de34d2ea8167d4ef4929b0c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f9ff10764de34d2ea8167d4ef4929b0c
record_format	dspace
spelling	oai:doaj.org-article:f9ff10764de34d2ea8167d4ef4929b0c2021-11-14T12:10:50ZTargeting lysosomes in human disease: from basic research to clinical applications10.1038/s41392-021-00778-y2059-3635https://doaj.org/article/f9ff10764de34d2ea8167d4ef4929b0c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41392-021-00778-yhttps://doaj.org/toc/2059-3635Abstract In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have been correlated with the development of numerous diseases. In this review, we interpreted the key biological functions of lysosomes in four areas: cellular metabolism, cell proliferation and differentiation, immunity, and cell death. More importantly, we actively sought to determine the characteristic changes and dysfunction of lysosomes in cells affected by these diseases, the causes of these changes and dysfunction, and their significance to the development and treatment of human disease. Furthermore, we outlined currently available targeting strategies: (1) targeting lysosomal acidification; (2) targeting lysosomal cathepsins; (3) targeting lysosomal membrane permeability and integrity; (4) targeting lysosomal calcium signaling; (5) targeting mTOR signaling; and (6) emerging potential targeting strategies. Moreover, we systematically summarized the corresponding drugs and their application in clinical trials. By integrating basic research with clinical findings, we discussed the current opportunities and challenges of targeting lysosomes in human disease.Mengdie CaoXiangyuan LuoKongming WuXingxing HeNature Publishing GrouparticleMedicineRBiology (General)QH301-705.5ENSignal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-28 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biology (General) QH301-705.5
spellingShingle	Medicine R Biology (General) QH301-705.5 Mengdie Cao Xiangyuan Luo Kongming Wu Xingxing He Targeting lysosomes in human disease: from basic research to clinical applications
description	Abstract In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have been correlated with the development of numerous diseases. In this review, we interpreted the key biological functions of lysosomes in four areas: cellular metabolism, cell proliferation and differentiation, immunity, and cell death. More importantly, we actively sought to determine the characteristic changes and dysfunction of lysosomes in cells affected by these diseases, the causes of these changes and dysfunction, and their significance to the development and treatment of human disease. Furthermore, we outlined currently available targeting strategies: (1) targeting lysosomal acidification; (2) targeting lysosomal cathepsins; (3) targeting lysosomal membrane permeability and integrity; (4) targeting lysosomal calcium signaling; (5) targeting mTOR signaling; and (6) emerging potential targeting strategies. Moreover, we systematically summarized the corresponding drugs and their application in clinical trials. By integrating basic research with clinical findings, we discussed the current opportunities and challenges of targeting lysosomes in human disease.
format	article
author	Mengdie Cao Xiangyuan Luo Kongming Wu Xingxing He
author_facet	Mengdie Cao Xiangyuan Luo Kongming Wu Xingxing He
author_sort	Mengdie Cao
title	Targeting lysosomes in human disease: from basic research to clinical applications
title_short	Targeting lysosomes in human disease: from basic research to clinical applications
title_full	Targeting lysosomes in human disease: from basic research to clinical applications
title_fullStr	Targeting lysosomes in human disease: from basic research to clinical applications
title_full_unstemmed	Targeting lysosomes in human disease: from basic research to clinical applications
title_sort	targeting lysosomes in human disease: from basic research to clinical applications
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/f9ff10764de34d2ea8167d4ef4929b0c
work_keys_str_mv	AT mengdiecao targetinglysosomesinhumandiseasefrombasicresearchtoclinicalapplications AT xiangyuanluo targetinglysosomesinhumandiseasefrombasicresearchtoclinicalapplications AT kongmingwu targetinglysosomesinhumandiseasefrombasicresearchtoclinicalapplications AT xingxinghe targetinglysosomesinhumandiseasefrombasicresearchtoclinicalapplications
_version_	1718429443596222464

Targeting lysosomes in human disease: from basic research to clinical applications

Ejemplares similares