Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae

Yousef Fazaeli1,2, Mostafa M Amini1, Hamed Ashourion3, Homayoun Heydari2, Abbas Majdabadi2, Amir Reza Jalilian2, Shamsozoha Abolmaali2,31Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Evin, Tehran, 2Agricultural, Medical and Industrial Research School, Moazzen Boulevard, R...

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Autores principales:	Fazaeli Y, Amini MM, Ashourion H, Heydari H, Majdabadi A, Jalilian AR, Abolmaali S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fa00436f210846ceb138824270c3f5d6
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spelling	oai:doaj.org-article:fa00436f210846ceb138824270c3f5d62021-12-02T05:02:11ZGrafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae1176-91141178-2013https://doaj.org/article/fa00436f210846ceb138824270c3f5d62011-12-01T00:00:00Zhttp://www.dovepress.com/grafting-of-a-novel-goldiii-complex-on-nanoporous-mcm-41-and-evaluatio-a8850https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yousef Fazaeli1,2, Mostafa M Amini1, Hamed Ashourion3, Homayoun Heydari2, Abbas Majdabadi2, Amir Reza Jalilian2, Shamsozoha Abolmaali2,31Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Evin, Tehran, 2Agricultural, Medical and Industrial Research School, Moazzen Boulevard, Rajaee Shahr, Karaj, 3Department of Biotechnology, Faculty of New Technologies and Engineering, Shahid Beheshti University, Evin, Tehran, IranAbstract: The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl3@PF-MCM-41 (AuCl3 grafted on pyridine-functionalized MCM-41). The toxicity of trichloro(2,4,6-trimethylpyridine)Au(III) and AuCl3@PF-MCM-41 in Saccharomyces cerevisiae (as a model system) was studied. The gold(III) complex showed a mid cytotoxic effect on yeast viability. Using the drug delivery system, nanoporous MCM-41, the gold(III) complex became a strong inhibitor for growth of yeast cells at a very low concentration. Furthermore, the animal tests revealed a high uptake of AuCl3@PF-MCM-41 in tumor cells. The stability of the compound was confirmed in human serum.Keywords: trichloro(2,4,6-trimethylpyridine)Au(III), MCM-41, Au(III), Saccharomyces cerevisiae, anticancer agentFazaeli YAmini MMAshourion HHeydari HMajdabadi AJalilian ARAbolmaali SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 3251-3257 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Fazaeli Y Amini MM Ashourion H Heydari H Majdabadi A Jalilian AR Abolmaali S Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae
description	Yousef Fazaeli1,2, Mostafa M Amini1, Hamed Ashourion3, Homayoun Heydari2, Abbas Majdabadi2, Amir Reza Jalilian2, Shamsozoha Abolmaali2,31Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Evin, Tehran, 2Agricultural, Medical and Industrial Research School, Moazzen Boulevard, Rajaee Shahr, Karaj, 3Department of Biotechnology, Faculty of New Technologies and Engineering, Shahid Beheshti University, Evin, Tehran, IranAbstract: The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl3@PF-MCM-41 (AuCl3 grafted on pyridine-functionalized MCM-41). The toxicity of trichloro(2,4,6-trimethylpyridine)Au(III) and AuCl3@PF-MCM-41 in Saccharomyces cerevisiae (as a model system) was studied. The gold(III) complex showed a mid cytotoxic effect on yeast viability. Using the drug delivery system, nanoporous MCM-41, the gold(III) complex became a strong inhibitor for growth of yeast cells at a very low concentration. Furthermore, the animal tests revealed a high uptake of AuCl3@PF-MCM-41 in tumor cells. The stability of the compound was confirmed in human serum.Keywords: trichloro(2,4,6-trimethylpyridine)Au(III), MCM-41, Au(III), Saccharomyces cerevisiae, anticancer agent
format	article
author	Fazaeli Y Amini MM Ashourion H Heydari H Majdabadi A Jalilian AR Abolmaali S
author_facet	Fazaeli Y Amini MM Ashourion H Heydari H Majdabadi A Jalilian AR Abolmaali S
author_sort	Fazaeli Y
title	Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae
title_short	Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae
title_full	Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae
title_fullStr	Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae
title_full_unstemmed	Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae
title_sort	grafting of a novel gold(iii) complex on nanoporous mcm-41 and evaluation of its toxicity in saccharomyces cerevisiae
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/fa00436f210846ceb138824270c3f5d6
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Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae

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