Urinary Telomerase Activity, C-erbB2, Malondialdehyde and Nitric Oxide as Possible Biological Markers of Bladder Cancer

The aim of the present study is to evaluate the possible diagnostic role of telomerase activity, c-erbB2, malondialdehyde and nitric oxide levels in the urine of bladder cancer patients. Eighty urine samples were taken from 3 groups of individuals; 1) Ten healthy age matched control subjects, 2) Twe...

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Autores principales:	Saad M. El-Gendy, Abdel Salam.I.M., Nahed Abd El-Wahab, Hussein.M.K, Gabry.M.S, El-Aaser.A.A
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2006
Materias:	Bladder cancer Bilharziasis Urinary telomerase activity C-erbB2 Malondialdehyde Nitric oxide. Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/fa0066dc2eec473fb6efb9b263a2da91
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id	oai:doaj.org-article:fa0066dc2eec473fb6efb9b263a2da91
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spelling	oai:doaj.org-article:fa0066dc2eec473fb6efb9b263a2da912021-12-02T10:53:45ZUrinary Telomerase Activity, C-erbB2, Malondialdehyde and Nitric Oxide as Possible Biological Markers of Bladder Cancer0250-46851303-829Xhttps://doaj.org/article/fa0066dc2eec473fb6efb9b263a2da912006-12-01T00:00:00Zhttp://www.turkjbiochem.com/2006/164.pdfhttps://doaj.org/toc/0250-4685https://doaj.org/toc/1303-829XThe aim of the present study is to evaluate the possible diagnostic role of telomerase activity, c-erbB2, malondialdehyde and nitric oxide levels in the urine of bladder cancer patients. Eighty urine samples were taken from 3 groups of individuals; 1) Ten healthy age matched control subjects, 2) Twenty schistosoma haematobium infectedpatients and 3) Fifty preoperative bladder cancer patients. Fresh urine samples(50mL) were collected and subjected to the assay of telomerase activity in urine sediment. Urine telomerase activity was increased in 72 % of bladder cancer cases. Bilharzial nonmalignant group showed normal telomerase activity as compared to normal healthy controls. Its increase in bladder cancer patients with bilharzial infection was statistically insignificant compared to non bilharzial cancer group. Urine telomerase activity of bladder cancer patients were increased in an ascendingmanner with tumor grades. Malondialdehyde level increased in bladder cancer patients with bilharzial infestation rather than those without bilharziasis, but the difference was statistically insignificant. C-erbB2 expression increased in 27 % of bladder cancer patients; while no single case of the bilharzial group showed positive c-erbB2 expression. Regarding the stage of tumor, nitric oxide level in bladder cancerpatients showed statistically significant difference between stage I, II and stage III (p=0.04). Statistically significant positive correlation between telomerase and c-erbB2 in bladder (r=0.456 & p=0.005) has been observed. The study of telomerase activity in the urine sediment of bladder cancer cases may be a useful marker for early detection of the disease.Saad M. El-GendyAbdel Salam.I.M.,Nahed Abd El-WahabHussein.M.KGabry.M.SEl-Aaser.A.ADe GruyterarticleBladder cancerBilharziasisUrinary telomerase activityC-erbB2MalondialdehydeNitric oxide.BiochemistryQD415-436ENTürk Biyokimya Dergisi, Vol 31, Iss 4, Pp 164-168 (2006)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bladder cancer Bilharziasis Urinary telomerase activity C-erbB2 Malondialdehyde Nitric oxide. Biochemistry QD415-436
spellingShingle	Bladder cancer Bilharziasis Urinary telomerase activity C-erbB2 Malondialdehyde Nitric oxide. Biochemistry QD415-436 Saad M. El-Gendy Abdel Salam.I.M., Nahed Abd El-Wahab Hussein.M.K Gabry.M.S El-Aaser.A.A Urinary Telomerase Activity, C-erbB2, Malondialdehyde and Nitric Oxide as Possible Biological Markers of Bladder Cancer
description	The aim of the present study is to evaluate the possible diagnostic role of telomerase activity, c-erbB2, malondialdehyde and nitric oxide levels in the urine of bladder cancer patients. Eighty urine samples were taken from 3 groups of individuals; 1) Ten healthy age matched control subjects, 2) Twenty schistosoma haematobium infectedpatients and 3) Fifty preoperative bladder cancer patients. Fresh urine samples(50mL) were collected and subjected to the assay of telomerase activity in urine sediment. Urine telomerase activity was increased in 72 % of bladder cancer cases. Bilharzial nonmalignant group showed normal telomerase activity as compared to normal healthy controls. Its increase in bladder cancer patients with bilharzial infection was statistically insignificant compared to non bilharzial cancer group. Urine telomerase activity of bladder cancer patients were increased in an ascendingmanner with tumor grades. Malondialdehyde level increased in bladder cancer patients with bilharzial infestation rather than those without bilharziasis, but the difference was statistically insignificant. C-erbB2 expression increased in 27 % of bladder cancer patients; while no single case of the bilharzial group showed positive c-erbB2 expression. Regarding the stage of tumor, nitric oxide level in bladder cancerpatients showed statistically significant difference between stage I, II and stage III (p=0.04). Statistically significant positive correlation between telomerase and c-erbB2 in bladder (r=0.456 & p=0.005) has been observed. The study of telomerase activity in the urine sediment of bladder cancer cases may be a useful marker for early detection of the disease.
format	article
author	Saad M. El-Gendy Abdel Salam.I.M., Nahed Abd El-Wahab Hussein.M.K Gabry.M.S El-Aaser.A.A
author_facet	Saad M. El-Gendy Abdel Salam.I.M., Nahed Abd El-Wahab Hussein.M.K Gabry.M.S El-Aaser.A.A
author_sort	Saad M. El-Gendy
title	Urinary Telomerase Activity, C-erbB2, Malondialdehyde and Nitric Oxide as Possible Biological Markers of Bladder Cancer
title_short	Urinary Telomerase Activity, C-erbB2, Malondialdehyde and Nitric Oxide as Possible Biological Markers of Bladder Cancer
title_full	Urinary Telomerase Activity, C-erbB2, Malondialdehyde and Nitric Oxide as Possible Biological Markers of Bladder Cancer
title_fullStr	Urinary Telomerase Activity, C-erbB2, Malondialdehyde and Nitric Oxide as Possible Biological Markers of Bladder Cancer
title_full_unstemmed	Urinary Telomerase Activity, C-erbB2, Malondialdehyde and Nitric Oxide as Possible Biological Markers of Bladder Cancer
title_sort	urinary telomerase activity, c-erbb2, malondialdehyde and nitric oxide as possible biological markers of bladder cancer
publisher	De Gruyter
publishDate	2006
url	https://doaj.org/article/fa0066dc2eec473fb6efb9b263a2da91
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Urinary Telomerase Activity, C-erbB2, Malondialdehyde and Nitric Oxide as Possible Biological Markers of Bladder Cancer

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