Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer

Jiafa Wu,1,2 Dongping Luo,3 Shengnan Li4 1School of Food and Bioengineering, Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China; 2Henan Engineering Research Center of Food Microbiology, Henan University of Science and Technology, Luoyang, Henan, People&a...

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Autores principales:	Wu J, Luo D, Li S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	traditional chinese medicine xihuang pill breast cancer network-pharmacology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fa03b27436634b2cad6204e736c37b1b
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spelling	oai:doaj.org-article:fa03b27436634b2cad6204e736c37b1b2021-12-02T12:34:07ZNetwork Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer1179-1314https://doaj.org/article/fa03b27436634b2cad6204e736c37b1b2020-12-01T00:00:00Zhttps://www.dovepress.com/network-pharmacology-oriented-identification-of-key-proteins-and-signa-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Jiafa Wu,1,2 Dongping Luo,3 Shengnan Li4 1School of Food and Bioengineering, Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China; 2Henan Engineering Research Center of Food Microbiology, Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China; 3The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China; 4School of Medicine, Henan Polytechnic University, Jiaozuo, Henan, People’s Republic of ChinaCorrespondence: Jiafa WuSchool of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, Henan, People’s Republic of ChinaEmail wujiafa@haust.edu.cnPurpose: The compound traditional Chinese medicine Xihuang pill (XHP) has been adopted to treat breast cancer (BC) for centuries, but its specific mechanism of action is unclear.Materials and Methods: The active ingredients and related targets of XHP were screened using the TCMSP and TCMID databases. GSE139038 was downloaded from the GEO database, and differentially expressed genes (DEGs) were analyzed. The intersection of targets and DEGs were chosen to build an ingredients–target genes network. Protein–protein interaction network construction and functional enrichment analysis of target genes were conducted.Results: A PPI network of 37 targets was constructed, and seven core nodes (FOS, MYC, JUN, PPARG, MMP9, PTGS2, SERPINE1) were identified. Functional enrichment analysis revealed that the aforementioned targets were mainly enriched in the IL-17, toll-like receptor, and tumor necrosis factor signaling pathways, which are deeply involved in the inflammatory microenvironment of tumors.Conclusion: This network pharmacology study indicated that XHP can inhibit the development of BC by targeting a variety of proteins and signaling pathways involved in the inflammatory microenvironment.Keywords: traditional Chinese medicine, Xihuang pill, breast cancer, network pharmacologyWu JLuo DLi SDove Medical Pressarticletraditional chinese medicinexihuang pillbreast cancernetwork-pharmacologyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 12, Pp 267-277 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	traditional chinese medicine xihuang pill breast cancer network-pharmacology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	traditional chinese medicine xihuang pill breast cancer network-pharmacology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wu J Luo D Li S Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer
description	Jiafa Wu,1,2 Dongping Luo,3 Shengnan Li4 1School of Food and Bioengineering, Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China; 2Henan Engineering Research Center of Food Microbiology, Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China; 3The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China; 4School of Medicine, Henan Polytechnic University, Jiaozuo, Henan, People’s Republic of ChinaCorrespondence: Jiafa WuSchool of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, Henan, People’s Republic of ChinaEmail wujiafa@haust.edu.cnPurpose: The compound traditional Chinese medicine Xihuang pill (XHP) has been adopted to treat breast cancer (BC) for centuries, but its specific mechanism of action is unclear.Materials and Methods: The active ingredients and related targets of XHP were screened using the TCMSP and TCMID databases. GSE139038 was downloaded from the GEO database, and differentially expressed genes (DEGs) were analyzed. The intersection of targets and DEGs were chosen to build an ingredients–target genes network. Protein–protein interaction network construction and functional enrichment analysis of target genes were conducted.Results: A PPI network of 37 targets was constructed, and seven core nodes (FOS, MYC, JUN, PPARG, MMP9, PTGS2, SERPINE1) were identified. Functional enrichment analysis revealed that the aforementioned targets were mainly enriched in the IL-17, toll-like receptor, and tumor necrosis factor signaling pathways, which are deeply involved in the inflammatory microenvironment of tumors.Conclusion: This network pharmacology study indicated that XHP can inhibit the development of BC by targeting a variety of proteins and signaling pathways involved in the inflammatory microenvironment.Keywords: traditional Chinese medicine, Xihuang pill, breast cancer, network pharmacology
format	article
author	Wu J Luo D Li S
author_facet	Wu J Luo D Li S
author_sort	Wu J
title	Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer
title_short	Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer
title_full	Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer
title_fullStr	Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer
title_full_unstemmed	Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer
title_sort	network pharmacology-oriented identification of key proteins and signaling pathways targeted by xihuang pill in the treatment of breast cancer
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fa03b27436634b2cad6204e736c37b1b
work_keys_str_mv	AT wuj networkpharmacologyorientedidentificationofkeyproteinsandsignalingpathwaystargetedbyxihuangpillinthetreatmentofbreastcancer AT luod networkpharmacologyorientedidentificationofkeyproteinsandsignalingpathwaystargetedbyxihuangpillinthetreatmentofbreastcancer AT lis networkpharmacologyorientedidentificationofkeyproteinsandsignalingpathwaystargetedbyxihuangpillinthetreatmentofbreastcancer
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Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer

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