High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality

Abstract Background The effects of vitamin C on clinical outcomes in critically ill patients remain controversial due to inconclusive studies. This retrospective observational cohort study evaluated the effects of vitamin C therapy on acute kidney injury (AKI) and mortality among septic patients. Me...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Thomas R. McCune, Angela J. Toepp, Brynn E. Sheehan, Muhammad Shaheer K. Sherani, Stephen T. Petr, Sunita Dodani
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Vitamin C therapy Sepsis Acute kidney injury In-hospital mortality Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/fa03d27a453f4c0199e17c996d9b164e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fa03d27a453f4c0199e17c996d9b164e
record_format	dspace
spelling	oai:doaj.org-article:fa03d27a453f4c0199e17c996d9b164e2021-11-21T12:42:30ZHigh dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality10.1186/s12882-021-02599-11471-2369https://doaj.org/article/fa03d27a453f4c0199e17c996d9b164e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02599-1https://doaj.org/toc/1471-2369Abstract Background The effects of vitamin C on clinical outcomes in critically ill patients remain controversial due to inconclusive studies. This retrospective observational cohort study evaluated the effects of vitamin C therapy on acute kidney injury (AKI) and mortality among septic patients. Methods Electronic medical records of 1390 patients from an academic hospital who were categorized as Treatment (received at least one dose of 1.5 g IV vitamin C, n = 212) or Comparison (received no, or less than 1.5 g IV vitamin C, n = 1178) were reviewed. Propensity score matching was conducted to balance a number of covariates between groups. Multivariate logistic regressions were conducted predicting AKI and in-hospital mortality among the full sample and a sub-sample of patients seen in the ICU. Results Data revealed that vitamin C therapy was associated with increases in AKI (OR = 2.07 95% CI [1.46–2.93]) and in-hospital mortality (OR = 1.67 95% CI [1.003–2.78]) after adjusting for demographic and clinical covariates. When stratified to examine ICU patients, vitamin C therapy remained a significant risk factor of AKI (OR = 1.61 95% CI [1.09–2.39]) and provided no protective benefit against mortality (OR = 0.79 95% CI [0.48–1.31]). Conclusion Ongoing use of high dose vitamin C in sepsis should be appraised due to observed associations with AKI and death.Thomas R. McCuneAngela J. ToeppBrynn E. SheehanMuhammad Shaheer K. SheraniStephen T. PetrSunita DodaniBMCarticleVitamin C therapySepsisAcute kidney injuryIn-hospital mortalityDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vitamin C therapy Sepsis Acute kidney injury In-hospital mortality Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Vitamin C therapy Sepsis Acute kidney injury In-hospital mortality Diseases of the genitourinary system. Urology RC870-923 Thomas R. McCune Angela J. Toepp Brynn E. Sheehan Muhammad Shaheer K. Sherani Stephen T. Petr Sunita Dodani High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality
description	Abstract Background The effects of vitamin C on clinical outcomes in critically ill patients remain controversial due to inconclusive studies. This retrospective observational cohort study evaluated the effects of vitamin C therapy on acute kidney injury (AKI) and mortality among septic patients. Methods Electronic medical records of 1390 patients from an academic hospital who were categorized as Treatment (received at least one dose of 1.5 g IV vitamin C, n = 212) or Comparison (received no, or less than 1.5 g IV vitamin C, n = 1178) were reviewed. Propensity score matching was conducted to balance a number of covariates between groups. Multivariate logistic regressions were conducted predicting AKI and in-hospital mortality among the full sample and a sub-sample of patients seen in the ICU. Results Data revealed that vitamin C therapy was associated with increases in AKI (OR = 2.07 95% CI [1.46–2.93]) and in-hospital mortality (OR = 1.67 95% CI [1.003–2.78]) after adjusting for demographic and clinical covariates. When stratified to examine ICU patients, vitamin C therapy remained a significant risk factor of AKI (OR = 1.61 95% CI [1.09–2.39]) and provided no protective benefit against mortality (OR = 0.79 95% CI [0.48–1.31]). Conclusion Ongoing use of high dose vitamin C in sepsis should be appraised due to observed associations with AKI and death.
format	article
author	Thomas R. McCune Angela J. Toepp Brynn E. Sheehan Muhammad Shaheer K. Sherani Stephen T. Petr Sunita Dodani
author_facet	Thomas R. McCune Angela J. Toepp Brynn E. Sheehan Muhammad Shaheer K. Sherani Stephen T. Petr Sunita Dodani
author_sort	Thomas R. McCune
title	High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality
title_short	High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality
title_full	High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality
title_fullStr	High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality
title_full_unstemmed	High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality
title_sort	high dose intravenous vitamin c treatment in sepsis: associations with acute kidney injury and mortality
publisher	BMC
publishDate	2021
url	https://doaj.org/article/fa03d27a453f4c0199e17c996d9b164e
work_keys_str_mv	AT thomasrmccune highdoseintravenousvitaminctreatmentinsepsisassociationswithacutekidneyinjuryandmortality AT angelajtoepp highdoseintravenousvitaminctreatmentinsepsisassociationswithacutekidneyinjuryandmortality AT brynnesheehan highdoseintravenousvitaminctreatmentinsepsisassociationswithacutekidneyinjuryandmortality AT muhammadshaheerksherani highdoseintravenousvitaminctreatmentinsepsisassociationswithacutekidneyinjuryandmortality AT stephentpetr highdoseintravenousvitaminctreatmentinsepsisassociationswithacutekidneyinjuryandmortality AT sunitadodani highdoseintravenousvitaminctreatmentinsepsisassociationswithacutekidneyinjuryandmortality
_version_	1718418863459139584

High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality

Ejemplares similares